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Biomedical subjects

L A Davis

Publications and source records attributed to L A Davis.

60 records · Page 4Linked to original sources

The distribution of scrapie-associated fibrils in neural and non-neural tissues of advanced clinical cases of natural scrapie in sheep.

The distribution of scrapie-associated fibrils (SAFs) throughout four brain regions, the pituitary gland, along the whole length of the spinal cord and in the sciatic nerve was assessed in 10 sheep terminally affected by scrapie and in four control sheep. Tonsils, retropharyngeal, broncho-mediastinal and mesenteric lymph nodes, the distal ileum, proximal colon and spleen were also examined for fibrils in all 14 sheep. Fibrils were detected in all four brain regions and throughout the length of the spinal cord in nine of the scrapie affected sheep. SAFs were not detectable in any of the sciatic nerve samples tested. In one of the 10 clinically affected sheep only minimal lesions were found by histopathology and fibrils were detected only from the cerebrum and one spinal cord region (taken at the C1 C2 vertebrae). Fibrils were not detected in the tonsils or retropharyngeal lymph nodes but were detected in other non-neural tissues of some of the scrapie-affected sheep. These tissues included pituitary gland, broncho-mediastinal and mesenteric portal lymph nodes, distal ileum, proximal colon and spleen. Fibrils could not be detected in any of the tissues taken from the four control sheep.

Animals↗

The modulation of coupled relaxation in porous media.

This work investigates the effects of modulation of the transverse and longitudinal relaxation of the surface-fluid/pore-fluid spin system in porous media. Important new NMR well logging applications identify pore fluids by varying the CPMG T(2) pulse spacing to discriminate on the basis of fluid diffusivities in applied and local static magnetic field gradients. However, anomalous laboratory CPMG T(2) results have been reported repeatedly over 25 years for various porous media filled with a single fluid. In relatively large pores, at near bulk conditions, the transverse relaxation of diffusing molecular spins should be proportional to the square of the CPMG pulse spacing tau, the susceptibility contrast at the pore wall and the applied gradient. Observed is a markedly linear tau dependence that saturates at a plateau for large tau. The effect is not quadratic in applied gradient or susceptibility. For large pores, the tau dependence and the saturation value are proportional to the surface-to-volume ratio of the pores. This is in distinct contrast to the behavior observed by Borgia, Brown and Fantazzini for systems with much smaller pores at higher magnetic fields. The large-pore anomalous behaviors can be explained as a modulation of the exchange between surface-fluid and pore-fluid spins, such as observed by Luz and Meiboom in 1963 for water enriched with quadrupolar 17O. Scalar coupling of the solid-surface spins to the fluid-surface spins was postulated by Kleinberg, Kenyon and Mitra as a dominant relaxation mechanism for the surface fluid. The CPMG tau effect can be described as the modulation of the exchange coupling by the CPMG pi pulses, which mix the magnetizations between the exchanging, strongly coupled spin systems of the pore-fluid and the surface-fluid, which is, in turn, weakly coupled by scalar or pseudo-scalar interactions to the fast-relaxing solid surface.

Calcium Carbonate↗

Four spondee threshold procedures: a comparison.

Two ascending and two descending procedures were used to obtain spondee thresholds from normally hearing and sensorineural hearing impaired subjects. Minimal differences were found when comparisons of threshold were made among all four procedures. Results indicated slightly more sensitive thresholds when the descending procedures were used and slightly poorer pure-tone average and spondee threshold agreement. Test-retest reliability was good for all four procedures, but large differences existed among the procedures in the amount of time and in the number of words required to establish threshold. Advantages and clinical implications are discussed.

Adult↗

Prospective study of congenital dislocation of the hip.

A prospective study involving 62 newborns diagnosed as having subluxable or dislocatable hips has established the efficacy of treating such cases from birth. Patients were treated first with a simple abduction splint, leading from a plastic abduction brace to the Pavlik harness and finally, a hip spica. Routine clinical examination showed this to be necessary until hip stability was achieved. This approach, together with continuing, detailed, clinical examinations, produced a 100% success rate with no iatrogenic complications.

Hip Dislocation, Congenital↗

Do we practice what we teach about childhood immunization in New Jersey?

BACKGROUND AND OBJECTIVES: Although childhood immunization is a benchmark for preventive service delivery in family practices, no data have been reported on childhood immunization in New Jersey family practice residencies. This study assesses immunization coverage among 2-year-olds in nine residencies and evaluates childhood immunization knowledge and barriers in 10 residency programs. METHODS: We performed a retrospective review of immunization records of 2-year-olds, using the Centers for Disease Control's Clinic Assessment Software Application, and analyzed a survey of knowledge and barriers to immunization completed by residents, nurses, and faculty. RESULTS: Among 726 children with four or more office visits, the mean percent of children immunized with the combination of four diphtheria-tetanus-pertussis, three polio, and one measles-mumps-rubella was 53% (range 31%-69%). The age-appropriate immunization rate was highest at 3 months (78%) and lowest at 16 months (29%). Among the 294 survey respondents, the mean knowledge score was 75% overall and 82% for faculty, 77% for nurses, and 71% for residents. There was moderate to good correlation of audit levels with knowledge, with 49% of the variation in immunization coverage explained by variation in knowledge. Lack of immunization records was reported by 47% as the most important office-related barrier. CONCLUSIONS: Immunization rates of 2-year-olds in nine New Jersey family practice residencies are below Healthy People 2000 goals. Low immunization rates in residency programs may improve with increased knowledge, an area for future study. Research into removing immunization-related barriers is also needed.

Adult↗