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Kumiko Ando

Publications and source records attributed to Kumiko Ando.

At least 19 recordsLinked to original sources
PubMed2006

Clinicoradiological factors influencing the reversibility of posterior reversible encephalopathy syndrome: a multicenter study.

PURPOSE: The aim of this retrospective study was to clarify the relation between the reversibility of posterior reversible encephalopathy syndrome (PRES) with three factors: the anatomical region of the brain involved, the background clinical cause, and the diffusion weighted image (DWI) intensity of PRES lesions. MATERIAL AND METHODS: This multicenter study, conducted by the PRES Study Group of the Neuroradiology Workshop, involved 52 cases from 28 institutions. Initial and follow-up magnetic resonance imaging were compared regarding the reversibility of PRES lesions according to anatomical location and clinical background. Initial DWI and apparent diffusion coefficient (ADC) maps were reviewed in 20 cases. RESULTS: Reversibility was significantly lower (P < 0.01) in the brain stem (44%) and deep white matter (47%) compared to the other cortical and subcortical areas (76%-91%). The reversibility was greater in the eclampsia subgroup followed by the hypertension and chemotherapy subgroups. DWI, even with ADC maps, had limitations in predicting the outcome of PRES lesions. CONCLUSION: The typical cortical and subcortical PRES lesions showed reversibility, whereas the brain stem and deep white matter lesions showed less reversibility. PRES due to eclampsia showed maximum reversibility compared to hypertension- and drug-related PRES. DWI, even with ADC maps, had limitations in predicting the course of PRES.

Adolescent↗
PubMed2006

A novel oxazine ring closure reaction affording (Z)-((E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)acetaldehydes and their anti-osteoclastic bone resorption activity.

A novel oxazine ring formation method was established using the reaction of 2-acetyl-(E)-3-styrylcarbonylaminobenzo[b]furans (4) with Vilsmeier-Haack-Arnold reagent to afford (E and Z)-((E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)acetaldehydes (5). (Z)-4-(8-Bromo-(E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)but-(E)-2-enoic acid ethyl ester (6b), derived from (Z)-5a, showed significantly potent anti-osteoclastic bone resorption activity comparable to 17beta-estradiol (E2).

Benzofurans↗
PubMed2006

Evaluation of vascular supply with cone-beam computed tomography during intraarterial chemotherapy for a skull base tumor.

A cone-beam lowers the X-ray exposure level and the contrast material dose used compared to those for the conventional angiography-computed tomography (angio-CT) technique. Herein we present a patient with a metastatic skull base bone tumor in which the subtraction image of cone-beam CT with a flat panel detector was useful for evaluating the vascular supply during superselective intraarterial chemotherapy. Although the image quality of cone-beam CT is poorer than that of conventional angio-CT, the cone-beam CT system is sufficient for clinical use.

Aged↗
PubMed2006

Disseminated necrotizing leukoencephalopathy following chemoradiation therapy for acute lymphoblastic leukemia.

Disseminated necrotizing leukoencephalopathy (DNL) is a potentially fatal complication of treatment involving intrathecal administration of chemotherapeutic agents such as methotrexate (MTX) alone or in combination with cranial radiotherapy (RT). We describe a case of acute lymphoblastic leukemia (ALL) treated with high-dose intravenous and intrathecal methotrexate combined with craniospinal RT resulting in DNL. Typical MR imaging features of progressive deep white matter lesions showing a characteristic pattern of enhancement after contrast was seen in this case. Deep white matter lesions with ring-like enhancement and calcifications were seen on CT; it showed a mass effect at one stage, which is not typical for DNL. Long-term clinical and imaging follow-up were helpful for the diagnosis in this case.

Antimetabolites, Antineoplastic↗
PubMed2006

Sertoli-stromal cell tumor of the right ovary: radiological-pathological correlation.

A case of Sertoli-stromal cell tumor of the right ovary is reported. The patient was a 50-year-old perimenopausal woman with abdominal distention due to a large pelvic tumor. She had no signs of androgen excess. A large solid sponge-like tumor with multicystic areas throughout, in which there were some small hemorrhagic spots, was shown on magnetic resonance (MR) imaging. No endometrial thickening of the uterus was seen. Pathology examination revealed a Sertoli-stromal cell tumor with intermediate-to-poor differentiation. The edematous, watery, sponge-like appearance on the MR images correlated with the pathological findings.

Contrast Media↗
PubMed2006

[Association between substance abuse problems and antisocial tendencies in male juvenile delinquents: A study using the Psychopathy Checklist, Youth Version].

AIMS: We examined an association between substance abuse problems and antisocial tendencies in male juvenile delinquents. METHODS: Subjects were 57 male adolescents consecutively incarcerated between December 2004 and February 2005 in a juvenile classification home. A self-reporting questionnaire was used to assess substance abuse problems in the subjects: Drug abuse problems were assessed by the Drug Abuse Screening Test (DAST-20), and alcohol abuse problems were assessed by the Quantities-Frequencies Scale (QFS). A semi-structured interview was also preformed according to the Psychopathy Checklist, Youth Version (PCL: YV). Associations between questionnaire responses and interview findings were examined using Pearson's correlation or Spearman's rank correlation test. RESULTS: Of our subjects, the 17.5% were recognized as a problematic drug abuser, and the 52.6% as a problematic drinker. Neither of the total DAST-20 nor QFS score was significantly correlated with the total PCL: YV score, and also with each score of the four PCL: YV subfactors. However, significant correlations were found between some items on the PCL: YV and the DAST-20 or QFS score. The DAST score was significant correlated with the PCL: YV item, "impression management" (rs=0.35, p<0.001), and the QFS score was significant correlated with "serious violations of conditional release" (rs=0.33, p<0.05) and "criminal versatility" (rs=0.48, p<0.001). CONCLUSION: More than a half of male juvenile delinquents had alcohol abuse problems. Alcohol intake may be considered to promote repetition and diversification of their antisocial behaviors, although overall antisocial tendencies were not associated with drug and alcohol abuse problems in male juvenile delinquents.

Adolescent↗
PubMed2005

Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity.

Variable benzo[b]furan derivatives having (E)- and (Z)-2-alkylcarbamoyl-1-methylvinyl groups at the 2-, 4- and 5-positions and a carboxylpropoxy or (1-phenyl)ethoxy group at the 7-position were prepared to find novel and selective leukotriene B4(LTB4) receptor antagonists. (E)-2-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4v) showed selective inhibition to the human BLT2 receptor (hBLT2). On the other hand, (E)-2-acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (7v) inhibited both human BLT(1) receptor (hBLT1) and hBLT2. The (E)-2-(2-diethylcarbamoyl-1-methylvinyl) group lay on approximately the same plane as the benzo[b]furan ring, whereas the (E)-4-(2-diethylcarbamoyl-1-methylvinyl) group had the torsion angle (45.7 degree) from the benzo[b]furan ring plane. However, the (Z)-(2-alkylcarbamoyl-1-methylvinyl)benzo[b]furans were inactive. The inhibitory activity depended on the conformation of the 2-diethylcarbamoyl-1-methylvinyl group.

Benzofurans↗
PubMed2005

Potential of superparamagnetic iron oxide in the differential diagnosis of metastasis and inflammation in bone marrow: experimental study.

RATIONALE AND OBJECTIVES: The utility of ferucarbotran for the diagnosis of bone metastases was investigated using tumor-implanted rabbits. The potential of ferucarbotran in the differential diagnosis of metastasis and inflammation was also investigated. METHODS: Twelve rabbits were divided into 2 groups (tumor and inflammation groups). Six rabbits of tumor group were inoculated with VX2 tumor cell suspension, and the 6 rabbits of the inflammation group were inoculated with 10% croton oil in the bone marrow of the right femur. All rabbits were imaged using a clinical MRI system. Signal intensity in the bone marrow of the right femur was measured in each rabbit before and after the intravenous injection of 8 micromol Fe/kg of ferucarbotran. As a control, the signal intensity in the bone marrow of the left femur (the normal, intact femur) was measured in each rabbit. The change in signal intensity of each group was compared statistically. After MRI imaging, the femora were removed, and sections were prepared for microscopic examination. RESULTS: Signal intensity in the right femur of the tumor group did not change after injection, although that of the inflammation group and the control group decreased. In the histologic findings, tumors were widely spread in the right femur of the tumor group. The infiltration of pseudoeosinocytes was induced in the right femur of the inflammation group. CONCLUSIONS: This animal study showed that ferucarbotran was useful to detect bone marrow tumors. In addition, ferucarbotran may have potential in the differential diagnosis of bone metastasis and some kinds of inflammation.

Animals↗
PubMed2005

[Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity].

Variable 7-carboxylpropoxy or (1-phenyl)ethoxybenzo[b]furan derivatives with (E)- and (Z)-2-alkylcarbamoyl-1-methylvinyl groups at the 2-, 4-, and 5-positions were prepared to find novel and selective leukotriene B(4) (LTB(4)) receptor antagonists. (E)-2-(2-Diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4v) showed selective inhibition of the human BLT(2) receptor (hBLT(2)). On the other hand, (E)-2-acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (7c) inhibited both human BLT(1) receptor (hBLT(1)) and hBLT(2). The (E)-2-(2-diethylcarbamoyl-1-methylvinyl) group lay on approximately the same plane as the benzo[b]furan ring, whereas the (E)-4-(2-diethylcarbamoyl-1-methylvinyl) group had a torsion angle (45.7 degrees ) from the benzo[b]furan ring plane. However, the (Z)-(2-alkylcarbamoyl-1-methylvinyl)benzo[b]furans were inactive. The inhibitory activity depended on the conformation of the 2-alkylcarbamoyl-1-methylvinyl groups.

Animals↗
PubMed2004

Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors.

(E)-2-Acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4b) with a characteristic conformation and (E)-2-(2-morpholinocarbo-1-methylvinyl)-7-ethoxycarbopropoxybenzo[b]furan ((E)-3b) were prepared and evaluated for their leukotriene B4(LTB4) antagonistic activity. Compound 4b showed potent antagonistic activity against human BLT1 and BLT2 receptors. Compound (E)-3b displayed selective BLT2 receptor antagonistic activity. Both compounds were inactive to cysteinyl LT receptors.

Animals↗
PubMed2004

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity.

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybut-2-enonyl)amino]benzo[b]furans (), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[b]furans (, ) were moderately active.

Animals↗
PubMed2004

[Usefulness of Cho/Cr ratio in proton MR spectroscopy for differentiating residual/recurrent glioma from non-neoplastic lesions].

PURPOSE: We evaluated the clinical usefulness of the Cho/Cr ratio of proton MR spectroscopy(1H-MRS) to differentiate residual/recurrent glioma from non-neoplastic lesions. PATIENTS AND METHODS: 20 cases of glioma were involved in this study(astrocytoma grade I-II: 7, oligodendroglioma: 1, astrocytoma grade III: 2, glioblastoma: 10). Seven of the patients underwent surgical resection only, 4 underwent surgical resection and radiotherapy(40-60 Gy), and 9 underwent surgical resection and radiotherapy with concurrent chemotherapy(14-60 Gy). 1H-MRS was performed on a 1.5 Tesla clinical MR unit using a 3D-chemical shift imaging sequence(1500 msec/270 msec/1 (TR/TE/excitations), and the Cho/Cr ratio was calculated in the voxel where neoplastic lesion was most suspected on MRI. The presence of lactate + lipid peak was also evaluated. All spectra were obtained after the contrast enhanced study. RESULTS: Cho/Cr ratios were significantly higher in cases of residual/recurrent tumors(mean +/- SD = 1.70 +/- 0.96) than in non-neoplastic lesions(mean +/- SD = 1.04 +/- 1.16) (Mann-Whitney U-test p = 0.047). If a Cho/Cr ratio of more than 1.5 was used as a marker of tumor presence, its sensitivity was 64%, specificity 83%, and accuracy 70%. One false-positive case that of radiation necrosis whose spectrum showed a high Cho/Cr ratio with markedly elevated lactate + lipid peak. CONCLUSION: The Cho/Cr ratio of 1H-MRS provides additional information to MRI in differentiating residual/recurrent gliomas from non-neoplastic lesions.

Adolescent↗
PubMed2004

[Visualization of brain perfusion by contrast-enhanced ultrasonography: preliminary study in rabbits].

PURPOSE: We evaluated the usefulness of an agent for contrast-enhanced ultrasonography (galactose parmitine acid: Levovist) in visualizing brain perfusion in rabbits. MATERIALS AND METHODS: Six rabbits were involved in this study. A hole in the skull bone was made under anesthesia and used as an acoustic window. An ischemic model (3 of 6 rabbits) was made by surgically occluding the M1 portion of the middle cerebral artery. Power Doppler images (PDI) and B-mode Harmonic images (HI) before and after intravenous injections of the contrast medium (150 mg/body) were obtained using the HDI5000 (ATL) equipped with a linear-type 5-12 Mhz probe. RESULTS: Smaller arteries were clearly visualized by contrast-enhanced PDI. However, enhancement of brain parenchyma was not clear on PDI. Enhancement of brain parenchyma was observed clearly on contrast-enhanced HI. Enhancement was strong during the first pass and then diminished quickly. In ischemic models, hypoperfusion in the right cerebral hemisphere (the occluded side) were clearly observed on contrast-enhanced HI. CONCLUSION: Brain perfusion in rabbits can be observed on contrast-enhanced Harmonic ultrasonographic imaging. It is suggested to be useful for human clinical cases, including hypoxic ischemic brain injury in infants.

Animals↗
PubMed2004

[A case of extrapontine myelinolysis precipitated by correction of a hyper-osmolar state].

We report a case of extrapontine myelinolysis (EPM) precipitated by correction of a hyper-osmolar state. A 7-year-old boy presented with disturbed consciousness. Serum BUN and Na level were 48 mg/dl and 196 mmol/L, respectively. T2-weighted images and FLAIR images of MRI visualized symmetrical bilateral high signal intensity areas in the external capsule and in the thalamus. In addition, the splenium of the corpus callosum showed high signal intensity. All these lesions showed high signal intensity on diffusion-weighted images. Extrapontine myelinolysis is precipitated not only by the rapid correction of a hypo-osmolar state but also by that of a hyper-osmolar state.

Child↗
PubMed2003

[Imaging findings of elongated styloid process syndrome (Eagle's syndrome): report of two cases].

Elongated styloid process syndrome, which is synonymous with Eagle's syndrome, is a rare disease. Although an elongated styloid process is not always symptomatic, if it compresses the cranial nerves and/or carotid artery, a patient can present with sore throat, dysphasia, or dysphoria of the throat. We present two cases of elongated styloid process syndrome, focusing on the imaging findings. The elongated styloid processes were visualized by panoramic photograms. However, CT images, especially 3DCT images, were useful in visualizing the elongated styloid process itself as well as the relationship between the styloid process and surrounding soft tissue.

Adult↗
PubMed2003

[A case of intravascular lymphomatosis with sinus thrombosis].

We report a rare case of intravascular lymphomatosis with massive tumor in the superior sagittal sinus (SSS), which caused sinus thrombosis. A 63-year-old man was incidentally found to have an enhancing mass in the superior sagittal sinus on MRI. The tumor manifested spontaneous regression during with 4 month's follow-up. Five months after the initial MR examination, T2-weighted MR images revealed a area of hyperintensity in the right occipital lobe. The area showed hypointensity on diffusion-weighted image and showed hyperintensity on ADC mapping, findings that are compatible with vasogenic edema.

Humans↗