Biomedical subjects

Khan Mohammad Sajid

Publications and source records attributed to Khan Mohammad Sajid.

2 recordsLinked to original sources

PubMed2006

Thyroid function in pulmonary tuberculosis.

OBJECTIVE: To evaluate the thyroid hormone economy in pulmonary tuberculosis (PTB). DESIGN: Cohort comparative study. PLACE AND DURATION OF STUDY: Multan Institute of Radiotherapy and Nuclear Medicine (MINAR) from January 2003 to June 2005. PATIENTS AND METHODS: The study included 266 confirmed cases of pulmonary tuberculosis (PTB), aged between 11 and 65 years, who had completed short course of chemotherapy. Two samples were collected from each patient, first after final diagnosis and second after completion of the treatment. Initial analysis of samples showed that 31 samples had both T3 (triiodothyronine) and T4 (thyroxine) in lower than normal range. One more sample in the middle of treatment was collected for these patients. Radioimmunoassays and immunoradiometeric assays were applied to estimate mean TT3, TT4 and TSH (thyroid stimulating hormone) levels. Students t-test was used to compare patient and normal values derived from 713 volunteers. RESULTS: The age had no effect on levels of T3, T4 and TSH in normal persons. Mean T3 and T4 values (0.74 nmol/l and 91.9 nmol/l) in PTB patients were significantly decreased (p < 0.001) with 50% and 11.6 % cases in lower than normal range respectively. Follow-up data on subgroup of 31 patients showed that both T3 and T4 levels improved after chemotherapy. TSH levels remained unaffected throughout. CONCLUSION: Both T3 and T4 levels were decreased in PTB but T4 levels were less affected. TSH was found unaffected by the disease. This confirms that PTB produces euthyroid sick syndrome (SES) i.e., decreased T3 and T4, and no change affected by 5'deiodinase (an enzyme that causes deiodination of T4). The levels improved after chemotherapy.

Adolescent↗

PubMed2004

Prostate specific antigen level in a fertilizer factory workers.

OBJECTIVE: To find the effect of the fertilizer factory environment on serum prostatic specific antigen (PSA) levels. DESIGN: A cohort comparative study. PLACE AND DURATION OF STUDY: The study was conducted at Immunoassay Laboratory of MINAR, Multan from June 2002 to January 2004. SUBJECTS AND METHODS: A total of 205 workers, all male, of Pak Arab Fertilizer Factory, Multan had their prostatic specific antigen (PSA) estimated. The age of the workers varied between 22 to 65 years (mean age = 48.3 +/- 8.5 years). The people belonged to various working groups and most of them were on normal Pakistani diet. They had been residing/working in the factory area for a period varying from 5 to 30 years. PSA levels were also estimated in 118 normal persons to serve as a control group. The age of these persons varied from 19 to 64 years. These were mostly hospital staff and general public not residing in the factory area and had no history of prostatic disease. Sensitive and specific immunoradiometric assay techniques were applied to measure the PSA concentrations in serum. RESULTS: Observed PSA levels in this population were between 0.2 and 11.5 ng/ml. Overall mean PSA level was 1.9 +/- 0.84 ng PSA/ml. Mean PSA level observed in control group was 0.73 +/- 0.64 ng/ml (upper 95% limit was 3.2 ng/ml). Comparison of PSA levels of factory workers with values in normal subjects showed that 9 out of 205 male workers (4.3% of total) had significantly elevated levels of PSA. In 2 workers (1% of total) observed PSA levels were above 10 ng/ml. The levels above this limit are most commonly observed in the cancer patients. CONCLUSION: A significant proportion of the workers of the fertilizer factory are at risk of malignant and non-malignant disease of the prostate.

Case-Control Studies↗