[Intracapsular carcinoma ex mixed tumor].
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Aged↗
Biomedical subjects
Khaled Ben Romdhane
Publications and source records attributed to Khaled Ben Romdhane.
[Langerhans cell histiocytois of the thyroid: a rare disease not to be ignored].
Thyroid involvement by Langerhans cell histiocytosis is rare. We report the case of a ten-year old boy who presented with a 5 cm goitre. He was treated for diabetes insipidus 14 months before. Thyroid isotopic scan showed hypoactivity of right lobe and revealed a cold left nodule. The patient was treated by right lobo-isthmectomy with adjuvant corticotherapy and chemotherapy (vinblastine). He is well with 12 months follow-up. Microscopic analysis demonstrated a diffuse infiltrate of thyroid parenchyma by sheets of CD1a positive Langerhans cells associated with lymphocyte foci. This case is remarkable by the abundance of Langerhans cells and scarcity of eosinophils. The diagnosis of thyroid langerhans cell histiocytosis should not be ignored in both children and adult patients.
Adrenal Cortex Hormones↗
[Fibromatosis of the breast: clinical and pathology analysis of two cases].
Fibromatosis of the breast is an uncommon benign disease that mimics carcinoma clinically as well as radiographically. Its microscopic diagnosis among spindle cell tumors is fundamental, especially on frozen sections. We report two cases of mammary fibromatosis observed in young woman (26 and 31 years old). The two were clinically and mammographically suspect. Diagnosis was made on frozen sections and confirmed on paraffin embedded specimen. The lesions are characterized by spindle cell proliferation of variable cellularity and collagenization. Few mitotic figures were present in one case. Several lesions must be considered in the differential diagnosis of mammary fibromatosis. Wide local excision is recommended for initial therapy, but local recurrence is frequent. In our cases, In spite of apparently complete excision, one patient relapsed.
Adult↗
[An uncommon tumor of the lung].
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Adenocarcinoma↗
Esthesioneuroblastoma metastatic to the breast in a young woman.
BACKGROUND: Metastases to the breast are rare and can be missed without knowledge of the clinical history. We report an unusual breast metastasis originating in an olfactory neuroblastoma. CASE: A breast metastasis from esthesioneuroblastoma occurred in a 20-year-old woman 2 years after the onset of the disease. The aspirates were hypercellular and composed of cellular aggregates and single cells with a monomorphic appearance. The cytoplasm was scanty and inconspicuous. The nucleus was large, with granular, hyperchromatic chromatin. Mitoses and apoptotic bodies were numerous. Because we were unaware of the past history at the time of the cytologic analysis, a definitive diagnosis was made only after pathologic study. CONCLUSION: Esthesioneuroblastoma metastatic to the breast must be considered in the differential diagnosis of breast metastases. Fine needle aspiration, in conjunction with clinical information, can be effective in the diagnosis of esthesioneuroblastoma metastatic to the breast.
Adult↗
Granulocytic sarcoma of the small intestine in a child without leukemia: report of a case with cytologic findings and immunophenotyping pitfalls.
BACKGROUND: Granulocytic sarcoma is a rare tumor that is often misdiagnosed as it can be confused with lymphoma. It has unique cytologic features independent of the site of the tumor and can be identified on fine needle aspiration. CASE: A 13-year old girl without a relevant medical history presented with an abdominal mass. Investigation revealed a tumor infiltrate in the small intestine and mesentery. The fine needle aspirate contained myeloid blasts with cytoplasmic granules. Immunohistochemistry on subsequent biopsy confirmed myeloid differentiation. There was no evidence of blood or bone marrow involvement suggestive of acute leukemia. The patient was well after 27 months of follow-up. CONCLUSION: Granulocytic sarcoma should be included in the differential diagnosis of any small intestine infiltrate. Cytomorphology is accurate and efficient for the diagnosis in conjunction with complete immunocytochemistry study.
Adolescent↗
[Atypical mesoblastic nephroma: histopathological entity or specific anatomoclinical form?].
Atypical mesoblastic nephroma is a rare kidney tumor mostly which occurred in early infancy. We describe two cases of atypical mesoblastic nephroma diagnosed in infants aged respectively 2 and 3 months. The tumors were completely removed and surgical margins were histologically free of disease. The two patients are well 14 and 9 months after surgery. Microscopically, the tumor was characterized by a densely cellular proliferation, high mitotic levels, cystic degeneration and necrosis. In the literature, the prognostic is good in patients aged fewer than 3 months and in cases in which the surgical removal was complete.
Diagnostic Imaging↗