[Standard surgical procedures in lung cancer].
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Humans↗
Biomedical subjects
Kenji Suzuki
Publications and source records attributed to Kenji Suzuki.
[Preoperative chemotherapy for lung cancer].
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Antineoplastic Combined Chemotherapy Protocols↗
[A cohort study of Japanese adolescent alcohol use and misuse (1): Observation for 2 years].
Japanese adolescent drinking has increased during the past 20 years. Two national surveys on adolescent drinking problems were conducted, but no prospective study has been performed in Japan. We started the first longitudinal cohort study on Japanese adolescent alcohol use and misuse in 1997. The purpose of the cohort study was to show factors that promote adolescent drinking, and whether adolescent problem drinkers will develop the early alcohol dependence syndrome. Eight hundred and two subjects were recruited from four junior high schools in Kanagawa prefecture. They were in grades 7 to 9, and the mean age was 13.5 years in 1997. The survey was conducted annually by mail using self reported questionnaires concerning adolescent drinking and alcohol-related problems. This report indicates the sociodemographic backgrounds of the subjects and showed increasing of drinking of the subjects from 1997 to 1999. At 1999 survey from 2 years after the starting point, the respondents numbered 629, and the follow-up rate was 78%. Drinking frequencies and quantities of the subjects increased year by year, and alcohol-related problems also increased. We divided the subjects into two groups based on changes in drinking status from the 1997 to the 1999 survey, the increased drinking group and no increased group, and compared these two groups concerning their family relationships, first drinking age and drinking status of parents with the responses of the 1997 survey. In the comparison of the two groups, many factors were significantly different, and logistic regression analyses were performed on these factors to determine drink promoting factors. Three factors were determined: earlier age of the first drink, not refusing friends' temptations to drink and less communication with their parents. We will continue the longitudinal cohort study to determine if these three factors promote adolescent drinking in the future.
Adolescent↗
Evaluation of respiratory modulation on the pulse wave amplitude in low-birth-weight neonate.
A slow oscillation of sympathetic vasoconstriction (Mayer waves) which is affected by the respiratory movements seems to appear as the fluctuation of pulse wave amplitude (PPG.P-P) in the frequency domain (0.1 Hz). Whether the vasomotor in low frequency has appeared in the pulse wave of the neonate and whether Mayer waves appear as the pulse wave oscillation of the immature low-birth-weight neonate are not fully understood from the point of autonomic nerve regulation mechanism. We therefore analyzed the frequency characteristics of PPG.P-P, respiration wave and its amplitude (RW.P-P) together with the heart rate variability (HRV) to examine the relationships between the frequency spectra.
Baroreflex↗
Association of SH2-B to phosphorylated tyrosine residues in the activation loop of TrkB.
Neurotrophins are essential for the survival and differentiation of neurons in the central and peripheral nervous systems. The binding of neurotrophins to their Trk receptors induces autophosphorylation of tyrosine residues and activation of several signaling components. However, the downstream signaling cascades remain to be fully elucidated. Here we describe molecular cloning of human SH2-B alpha, PH and SH2-domain-containing adaptor protein, as a TrkB binding protein, and how SH2-B alpha associate with the cytoplasmic domain of TrkB at phosphorylated tyrosine residues in the kinase activation loop. There was no distinct inhibitory or inducing effect on kinase activity detected by either a full-length or an SH2 domain of SH2-B alpha in vitro, even though the regulation mechanism of the activation loop on tyrosine kinase activity has been described. In addition to SH2-B alpha, the expression of three SH2-B alternative splice variants, SH2-B beta, gamma and delta, was detected in human cell lines. These splicing variants have unique carboxyl-terminal amino acid sequences due to insertion sequences as well as reading frameshifts.
Amino Acid Sequence↗
Intrapulmonary lymph nodes: thin-section CT features of 19 nodules.
PURPOSE: The purpose of this study was to describe the thin-section CT features of intrapulmonary lymph nodes that accompanied primary or metastatic lung tumors. METHOD: A retrospective analysis of thin-section CT features was performed on 19 nodules in 16 patients with pathologically confirmed intrapulmonary lymph nodes that accompanied primary or metastatic lung tumors. RESULTS: Of the 16 patients, 13 had a solitary nodule and 3 had two nodules. All nodules were distributed in the middle lobe, lingula, or lower lobe. On thin-section CT images, the nodule was located abutting the visceral pleura (n = 10) or within 8 mm of the visceral pleura (n = 9). The thin-section CT findings showed that most of the nodules were well circumscribed (n = 18), homogeneous (n = 19), ovoid (n = 10), or round (n = 9) and smaller than 12 mm in maximal diameter. The surrounding lung field was normal (n = 16). CONCLUSION: Intrapulmonary lymph nodes are subpleural in the lower lung field. On thin-section CT, they are well circumscribed, homogeneous, round or ovoid, and smaller than 12 mm in maximal diameter. In the differential diagnosis of subpleural nodules located in the lower lung field, it should be kept in mind that they may be intrapulmonary lymph nodes even though the patient has malignancy.
Aged↗
Clustered features of the metabolic syndrome and the risk for increased aortic pulse wave velocity in middle-aged Japanese men.
The association between different features of the metabolic syndrome (MS) (obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol level, hypertriglyceridemia, high fasting plasma glucose level, and hyperuricemia) and the risk for increased aortic pulse wave velocity (PWV) of > or = 8.0 m/sec was examined in 2431 Japanese men aged 35 to 54 years who were not taking antihypertensive medication. After controlling for age, cigarette smoking, and alcohol intake, the odds ratios for increased aortic PWV in subjects with 1, 2, 3, and > or = 4 features of the MS, compared with those without features of the MS, were 1.35 (95% CI, 0.86 to 2.11), 1.90 (95% CI, 1.18 to 3.06), 1.57 (95% CI, 0.89 to 2.76), and 2.38 (95% CI, 1.26 to 4.49), respectively (p for trend = 0.003). A 9-year longitudinal study was also performed to prospectively examine the association between clustered features of the MS and the development of increased aortic PWV in 2073 men without aortic stiffness with a PWV < 8.0 m/sec and without antihypertensive medication during the follow-up period. The multivariate-adjusted hazard ratios for the incidence of increased aortic PWV in subjects with 1, 2, 3, and > or = 4 features of the MS, compared with those without features of the MS, were 1.39 (95% CI, 1.10 to 1.77), 1.46 (95% CI, 1.1 1 to 1.92), 1.75 (95% CI, 1.27 to 2.40), and 2.22 (95% CI, 1.52 to 3.25), respectively (p for trend < 0.001). These results suggest that clustered features of the MS are closely associated with the risk for increased aortic PWV in middle-aged Japanese men.
Adult↗
Telangiectasia macularis eruptiva perstans in polycythemia rubra vera.
We describe a 65-year-old Japanese man with a 20-year history of telangiectasia macularis eruptiva perstans, who developed polycythemia rubra vera and duodenal ulcer 10 and 12 years respectively after the onset of mastocytosis. Involvement of mast cells was found in neither bone marrow nor gastrointestinal tract. Immunohistochemical staining revealed that the mast cell was positive for both tryptase and chymase, indicating the nature of cutaneous mast cells. Despite the coexistence of a hematologic disorder, our case is suggested to have cutaneous but not systemic mastocytosis presenting as telangiectasia macularis eruptiva perstans.
Aged↗