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Kenji Kashiwagi

Publications and source records attributed to Kenji Kashiwagi.

42 records · Page 3Linked to original sources
PubMedDate not supplied

A case of cystoid macular edema associated with latanoprost ophthalmic solution.

BACKGROUND: Although there have been reports of adverse effects after use, it is unclear whether latanoprost ophthalmic solution contributes to the development of cystoid macular edema (CME). CASE: A 71-year-old man underwent lens extraction, the insertion of an intraocular lens, and vitrectomy for elevated intraocular pressure (IOP) associated with lens subluxation in the left eye. After the surgery, antiglaucoma ophthalmic solutions controlled IOP well for over a year, maintaining good visual acuity with no abnormalities in the fundus. OBSERVATIONS: Two months after the previously prescribed antiglaucoma ophthalmic solutions were replaced by latanoprost, the patient's visual acuity decreased and CME developed. When latanoprost was replaced by other antiglaucoma ophthalmic solutions for controlling IOP, CME disappeared and visual acuity returned to the base level. CONCLUSIONS: Latanoprost may be involved in the development of CME. Patients who have undergone vitreous surgery or those with aphakia should be carefully observed for the possible development of CME associated with the use of latanoprost, even a long time after surgery.

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PubMedDate not supplied

Comparison of the effectiveness of scanning laser polarimetry and optical coherence tomography for estimating optic nerve fibre layer thickness in patients with glaucoma.

PURPOSE: The effectiveness of scanning laser polarimetry (by the nerve fibre analyser, NFA) and of optical coherence tomography (OCT) in estimating nerve fibre layer thickness (NFLT) and the correlations between NFLT and cup-to-disc (C/D) ratio or values of mean deviation (MD) from static visual field tests were compared using patients with glaucoma. MATERIALS AND METHODS: Twenty-four eyes from 24 glaucoma patients were enrolled. The NFLT was measured along a circle with a diameter 1.5 times that of the optic disc around the optic disc. The averaged estimated NFLT of the circle or of each quadrantal NFLT (nasal, temporal, superior, inferior) was compared. RESULTS: The co-variant indexes measured by the NFA were significantly smaller than those measured by OCT in both the averaged NFLT (p = 0.0002) and in each quadrantal NFLT (p < 0.05). The C/D ratio was significantly correlated with the averaged NFLT when measured by OCT (r = 0.425, p = 0.038), but not by the NFA (r = 0.179, p = 0.407). However, when measured by OCT, these values showed a significant correlation (r = 0.425, p = 0.039). Although both the OCT and NFA data showed significant correlations between NFLT and the MD (p = 0.0002 and p = 0.038, respectively), the OCT data showed a stronger correlation than did the NFA data (r = 0.677 and r = 0.422, respectively). The correlation between the averaged NFLTs obtained by NFA and OCT was not significant (r = 0.289, p = 0.172). CONCLUSION: OCT is thought to have an equal or better effectiveness for estimating NFLT, in spite of a lower reproducibility than that of the NFA.

Diagnostic Techniques, Ophthalmological↗
PubMedDate not supplied

Variance between program versions in measuring optic nerve fiber layer thickness using optical coherence tomography.

PURPOSE: To compare nerve fiber layer thickness (NFLT) in patients with glaucoma measured by two versions of an analysis program utilizing optical coherence tomography (OCT) with reference to the cup-to-disk (C/D) ratio and the mean deviation (MD) score of a static visual field test. METHODS: Twenty-four eyes from 24 glaucoma patients were enrolled. The NFLT was measured by OCT along a circle around the disk with the circle diameter being 1.5 times that of the disk itself. The NFLTs evaluated by the two versions A4.01 and A6.01 were compared with respect to the C/D ratio and MD score. RESULTS: The mean NFLTs evaluated by version A6.01 were 61.2% greater than those evaluated by version A4.01 (p < 0.001). The NFLTs in all quadrants evaluated by A6.01 were also greater than those evaluated by A4.01. Both A6.01 and A4.01 showed a significant correlation with the C/D ratio and MD score. Although A6.01 showed a better correlation with the C/D ratio than A4.01, both A4.01 and A6.01 showed similarly good correlations with MD. CONCLUSION: The NFLTs evaluated by the two versions differed significantly with regard to some parameters. These results should be taken into account in evaluating NFLTs when utilizing OCT.

Adult↗
PubMedDate not supplied

Comparison of efficacy and tolerability between two gel-forming timolol maleate ophthalmic solutions in patients with glaucoma or ocular hypertension.

PURPOSE: To compare two gel-forming timolol maleate ophthalmic solutions, Timoptol XE and Lizmon TG, in regard to efficacy and tolerability in patients with glaucoma or ocular hypertension by means of a patient-masked prospective randomized crossover study. SUBJECTS AND METHODS: A total of 37 patients with glaucoma or ocular hypertension under treatment with antiglaucoma ophthalmic solutions including 0.5% twice-daily timolol maleate participated in this study. Only timolol maleate was withdrawn and either Timoptol XE or Lizmon TG was randomly allocated. After instillation for 1 month, the other ophthalmic solution was subsequently instilled for another month. Routine ophthalmic examination including slit-lamp examination and intraocular pressure (IOP) monitoring was conducted before instillation of gel-forming ophthalmic solutions and just after completing the instillation of each ophthalmic solution. Patient questionnaire surveys were also performed just after completing the instillation of each ophthalmic solution. RESULTS: Mean IOP, just before the withdrawal of timolol ophthalmic solution, was 16.4 +/- 2.9 mm Hg. At the end of Timoptol XE or Lizmon TG instillation, mean IOPs were 16.3 +/- 2.5 or 16.3 +/- 3.0 mm Hg, respectively. The results of the questionnaire survey showed no significant difference between Timoptol XE and Lizmon TG in regard to all survey items. Twenty-nine patients (78.4%) preferred to use gel-forming timolol solutions rather than twice-daily timolol ophthalmic solution. The presence of concurrently used ophthalmic solutions did not effect the incidences of subjective symptoms. The incidences of objective adverse effects were not significantly different between two gel-forming timolol ophthalmic solutions. CONCLUSION: Both gel-forming timolol ophthalmic solutions could be good choices for glaucoma treatment.

Adult↗
PubMedDate not supplied

Effect of hospitalization on intraocular pressure in patients with normal-tension glaucoma.

OBJECTIVE: To investigate the effect of hospitalization on intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG). METHODS: The study was conducted in 52 patients with a definite diagnosis of NTG. The correlation between IOP measured from 9.00 a.m. to 12.00 p.m. on an outpatient basis within 3 months each prior to and after hospitalization (ambulatory IOP) and IOP measured during the same time period after admission (inpatient IOP) was investigated in NTG patients. RESULTS: Inpatient IOP (13.9 +/- 2.4 mm Hg) was significantly lower than ambulatory IOP (15.2 +/- 2.1 mm Hg), with a difference of 1.3 +/- 2.0 mm Hg (p < 0.01). The difference between inpatient IOP and ambulatory IOP was negatively correlated with inpatient IOP (r = 0.58, p < 0.01). CONCLUSIONS: These results revealed that hospitalization decreased IOP in NTG patients, with the decrease being particularly pronounced in cases of low ambulatory IOP. Interpretation of inpatient IOP should be carefully included in glaucoma treatment.

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