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Ken Nagao

Publications and source records attributed to Ken Nagao.

22 records · Page 2Linked to original sources
PubMed2002

An early and complete reperfusion strategy for acute myocardial infarction using fibrinolysis and subsequent transluminal therapy--The FAST trial.

The efficacy and safety of fibrinolysis and subsequent transluminal (FAST) therapy were evaluated in 195 patients with acute myocardial infarction (AMI) for the early achievement of thrombolysis-in-myocardial-infarction grade 3 (TIMI-3) flow in the infarct-related artery. Intravenous thrombolysis using the optimal dose of a thrombolytic agent was initiated immediately after arrival in the emergency room, followed by coronary angiography and adjuvant percutaneous coronary intervention. A comparison of the thrombolysis alone (n=83) and thrombolysis plus intervention (n=112) groups showed significant differences in the time interval from hospital arrival to achievement of TIMI-3 flow (66.2+/-23.7 vs 111.6+/-29.6 min, p<0.0001), creatine kinase-MB release (295+/-201 vs 468+/-322 U/L, p=0.0003) and peak troponin T (23.6+/-16.9 vs 38.9+/-25.9 ng/ml, p<0.0001). No significant differences were observed in either 30-day mortality or complications. The TIMI-3 flow at the initial angiography was significantly higher with a single bolus of mutant tissue-type plasminogen activator (t-PA) monteplase than with an accelerated infusion of t-PA (60% vs 32%, p=0.005). In conclusion, the early restoration of TIMI-3 flow by FAST therapy reduced the degree of myocardial damage with a low risk of complications. TIMI-3 flow was achieved at an earlier stage with monteplase and this agent may be beneficial in the FAST therapy.

Angioplasty, Balloon↗
PubMed2002

[Review of arrythmias related to acute myocardial infarction and its treatment].

Because reperfusion therapy for AMI has been widely performed, complicated fatal ventricular arrythmias related to AMI has been dramatically decreased. However, there still remain the incidence of fetal arrhythmias such as ventricular fibrillation(VF), ventricular tachycardia(VT) at the early phase in occurrence of AMI. Besides spreading bolus intravenous administration of mutant-tPA, Bystander CPR, Public access defibrillation (PAD), and setting of automated external defibrillators(AED) in the public facilities are actually required to reduce the mortality of AMI. In this article, we reviewed that arrhythmias associated with AMI and strategy for treatments of complicated arrhythmias in the clinical settings.

Cardiopulmonary Resuscitation↗