Biomedical subjects

Keizo Ohnaka

Publications and source records attributed to Keizo Ohnaka.

20 records · Page 2Linked to original sources

PubMed2003

[Glucocorticoid-induced osteoporosis and anabolic effect of PTH on bone].

Glucocorticoid-induced osteoporosis(GIO)is the major cause of secondary osteoporosis, and prevention of GIO is thought to be essential to avoid bone fracture. Direct inhibitory effect of glucocorticoid on bone formation is considered as the main mechanism of GIO. Clinical guidelines have recommended that bisphosphonate is the first choice for the treatment of GIO. Bone mineral density in patients with GIO has recently been reported to be increased by the treatment with parathyroid hormone(PTH)at a low dose and by intermittent administration.

English Abstract↗

PubMed2003

[Pathogenesis and treatment of glucocorticoid-induced osteoporosis].

Prevention of glucocorticoid-induced osteoporosis (GIO) and the subsequent bone fractures is now essential for QOL. Direct inhibitory effect of glucocorticoid on bone formation and promotion of apoptosis of bone cells are currently thought to be the major mechanism of GIO. Bone resorption varies dependent on dose and length of administration of glucocorticoid, but the bone formation rate is considered to be always below the bone resorption rate. Most recent clinical guidelines have recommended bisphosphonates as the first choice for the treatment of GIO.

English Abstract↗