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Biomedical subjects

Kazuya Kiyota

Publications and source records attributed to Kazuya Kiyota.

6 recordsLinked to original sources
PubMed2006

[Three cases of inhalation of household pyrethroid and metoxadiazone insecticides with remarkable dyspnea].

Household insecticides containing pyrethroids as their active ingredient are widely used in Japan. We encountered three cases of dyspnea caused by insecticides containing pyrethroids and metoxadiazone. The first case was a 52-year-old woman who suffered with dyspnea after breathing interior air following use of a fumigating insecticide. Although bronchoscopy revealed laryngotracheal edema, symptoms improved following administration of hydrocortisone and midazolam. Although the second case was a 63-year-old man who suffered with dyspnea as a result of direct aerosol insecticide inhalation due to missuse, symptoms had dissipated when the patient arrived at the hospital. The third case was a 20-year-old man with allergies who presented with dyspnea due to exposure to an aerosol insecticide three days after use. An allergic mechanism was thought to be involved. Reports of respiratory symptoms and allergic reactions caused by inhalation of pyrethroids are rare. Although the levels of exposure were low in all three cases compared to oral lethal dosage, these cases presented with serious respiratory symptoms, thus suggesting the need for further considerations regarding latent cases and safety.

Adult↗
PubMed2003

[Intestinal edema caused by ingested formalin].

A 65-yr-old man treated for depression was transferred to our hospital. He ingested over 150 ml of formalin for suicidal attempt. On admission, he was hypotensive, developing acute renal failure and liver dysfunction. During first 36 hours, he needed 21 l of lactate Ringer solutions to maintain enough urination. The abdominal computed tomography showed obvious edema of intestine and endoscopic findings of the upper digestive tract were corrosive erosions. We started proton pump inhibiter on the first day. After a week, they changed in many ulcers with smooth-surfaced elevation on the greater curvature of the stomach. On the 15th hospitalized day, he was discharged from our hospital without sequelae. Formalin consists of forty percent solution of formaldehyde and methanol. Ingestion of formaldehyde may cause burning in the digestive systems and harmful effect to major organ such as kidney or liver. Although previous reports said that formalin has direct toxicity to major organs, we could discharge him without sequelae by treatment with large amount of fluid resuscitation.

Aged↗
PubMed2003

[Case report-fatal snail bait (metaldehyde) overdose presenting aspiration pneumonia].

A-55-year-old man ingested unknown amount of snail poison bait containing metaldehyde. He was mentally retarded and presented pica. On admission, his vital sign was stable, and the extremeties were spastic. Then, gastric lavage was unsuccessful because of massive unbited food. Activated charcoal and cathartic were administrated. On the next day, general convulsion occurred and respiratory distress advanced, so he was intubated. On the 3rd day, infiltration shadow appeared on chest roentogenogram and, his respiration was assisted mechanically. Thereby, acute lung injury advanced regardless of tracheostomy, kinetic therapy, antibiotics and steroid pulse therapy. He died of respiratory failure on the 33rd day. Serum test showed HBs and HBe antigen, CT scan revealed ascites and splenomegaly; the clinical course might be worsened by liver cirrhosis. HPLC revealed metaldehyde in the serum (total 80.6 microg/ml). He ingested 2.7 g of metaldehyde maximally estimated. Although Japan Poison Information Center reported that snail poison bait poisoning is often in dogs in Japan, human poisoning is rare.

Acetaldehyde↗
PubMed2002

[Fatal calcium polysulfide overdose presenting corrosive chemical injury of esophagus and sulf-hemoglobinemia].

A-79-year-old woman ingested a cup of unknown violet agricultural solution intentionally. She was vomiting and smelt of sulfur. Arterial blood gas showed metabolic acidosis and marked cyanosis regardless of relatively high PaO2, caused by sulfhemoglobinemia. A nasogastric tube could not be inserted because of marked stenosis caused by endoscopically proven severe corrosive chemical injury (burn) of esophagus. Considering the smell and the clinical presentation, we concluded that the causative agent was calcium polysulfide or lime-sulphur solution, a common agricultural product used as a fungicide. Despite supportive therapy including infusion of NaNO2, the patient expired 4.5 hours after ingestion. Calcium polysulfide ingestions cause direct injury to the upper gastrointestinal tract, and react with gastric HCl producing poisonous H2S gas, which interferes cytochrome oxidase activity, developing tissue hypoxia, shock, and metabolic acidosis. Sulfhemoglobin is also produced causing severe cyanosis.

Aged↗