Biomedical subjects

Kazimierz Janicki

Publications and source records attributed to Kazimierz Janicki.

6 recordsLinked to original sources

PubMed2003

[Angiosarcoma (hemangiosarcoma) cordis].

The case of a young 32 year old male with a primary cardiac angiosarcoma is reported. The neoplasm manifested itself by a quickly increasing cardiac tamponade but without metastases. The nonradical resection of the tumor was made because of local invasion with tumor tissue. The patient was followed-up for 3 years after the surgery and no recurrence of the malignant process was observed. Cardiac angiosarcoma is a very rare malignant tumor of soft tissues. In spite of significant progress in clinical treatment, for a patient diagnosed antemortem with cardiac angiosarcoma, the long-term expectations are usually very poor. Commonly known risk factors for this group of neoplasms (haemangioma of skin, chroniclymphedema, chronic post-tuberculosis pleurisy, X-ray, thorium dioxide) cannot be easily associated with the primary cardiac angiosarcoma cases. The search for chromosomal anomalies and gene mutations leading to cardiac angiosarcoma is ongoing. There is hope that recently obtained evidence for mutation of the p53gen, will provide a better understanding of this heart neoplasia.

Adult↗

PubMed2002

[A case of actinomycosis of the palatine tonsils--diagnostic difficulties].

Here authors present a rare case of actinomycosis of the pallatinal tonsilla, which had a form of tumor. Bacteriological tests revealed only some saprophytical bacteria in pharynx. After surgical treatment of disease was done, patient got back to health quickly, and histopathological exam showed that this was actinomycosis.

Actinomycosis↗

PubMed2002

[A case of giant pleomorphic adenoma of the cheek with two malignant centers].

The authors present the case pleomorphic adenoma of a patient aged 77 of atypical location with two malignancy center. After performed diagnostic for an operation the tumor resected. The histopathologic examination proved in the pleomorphic adenoma the cylindromatosum and cancer solid vertens.

Adenoma, Pleomorphic↗

PubMed2002

[Diagnostic difficulties in scanty symptomatic pituitary tumor].

Adenomas are the most frequent pituitary tumours and constitute up to 8% of intracranial tumors. They are divided according to size into microadenomas and macroadenomas, the latter are expanding suprasellary, and also infiltrate the base of the skull. Depending on histological staining, they are divided into neutrophilic, acidophilic and basophilic adenomas. Hormonally active adenomas are responsible for Cushing, Forbes and Albright diseases and acromegaly. Macroadenomas are responsible for chronic hypothalamo-pituitary axis insufficiency. Clinically, pituitary tumours produce local (headaches and vision deficiency) and general signs like hormonal disturbances. Diagnosis, localisation and size of pituitary tumours is made using radiological techniques. Treatment may consist of surgical (removing of the tumour and chiasma opticum decompression), pharmaco and radiotherapy. The case described illustrates the diagnosis of an oligosymptomatic pituitary tumour.

Adenoma↗

PubMed2002

[Exogenous nitric oxide and gallbladder contractility in humans].

The physiological function of the gallbladder (GB) is to deliver concentrated bile to the duodenum after a meal. This requires a complex coordination of the motor, secretory, and absorptive functions of the gallbladder. Control of GB motor functions involves a constant interplay between a large number of stimulatory and inhibitory hormones and neurotransmitters. With regard to intrinsic neurotransmitters, nitric oxide (NO) acts as a neurotransmitter in nonadrenergic, noncholinergic (NANC) pathways of the gallbladder. This compound has been found to inhibit GB tone and contraction in both animal and human studies. The Purpose of the present study was to examine the effects of exogenous NO donors such as glyceryl trinitrate (GTN), molsidomine (MO) and L-arginine (L-Arg) on fasting GB volume and on meal-stimulated gallbladder contraction expressed as ejection fraction (EF). The healthy subjects (13 men and 17 women), age range 19-41 years participated in this study. GB volume was examined by means of an ultrasonographic method. Volumes of GB were calculated using the sum of cylinders method as described by Dodds. EF was measured every 15 min up to a total observation period of 2 h. After recording of control values, 0.5 mg GTN was administered sub-lingually, or 4 mg MO orally or L-Arg (12.63 g of L-Arg in 300 ml of 0.9% NaCl) was infused i.v. over 120 min. It was found that the fasted GB volume was increased after GTN by 22 +/- 10% and after MO by 28 +/- 4% (p < 0.05). Post-prandial EF was reduced maximally by 22 +/- 9% (p < 0.05) after pretreatment with GTN and by 32 +/- 8% (p < 0.01) after MO. Whereas L-Arg was without any effect on resting GB, however it reduced significantly stimulated EF. These findings support the earlier knowledge that NO, released from its exogenous donors has the potent inhibitory effect on human gallbladder motor activity.

Administration, Oral↗

PubMed2002

[A case of Kartagener's syndrome].

The authors present a case of a soldier with Kartagener syndrome and bilateral purulent maxillary sinusitis with nasal polyps and pneumonia. Kartagener syndrome is originally described as the combination of situs inversus, bronchiectasis and sinusitis. Kartagener syndrome is a part of immotile cilia syndrome. Mild before the age of 18 recurrent pneumonia, chronic sinusitis, chronic rhinitis and nasal polyps occurred. Typical therapeutic management is discussed but infections prophylaxis, general treatment and physiotherapy are the base of good general condition and significantly improve prognosis.

Adult↗