Biomedical subjects

Katarzyna Plata-Nazar

Publications and source records attributed to Katarzyna Plata-Nazar.

7 recordsLinked to original sources

PubMed2006

[Prevalence of ESBL strains in urinary tract infections in children in 1996 and 2004].

Ethiological agents in urinary tract infections and prevalence of bacterial strains producing extended spectrum of beta-lactamases isolated from urine of children with urinary tract infections were compared. Patients were hospitalized in Department of Pediatry, Pediatric Gastroenterology and Oncology of Medical University of Gdańsk in 1996 and 2004. Seventy bacterial strains isolated from urine in 1996 and 113 strains isolated in 2004 were analyzed. In both years Enterobacteriaceae were the most frequently encountered with Escherichia coli predominance. Proteus spp. (10.9%), Enterobacter spp. (7.1%), Klebsiella spp. (4.4%), and Enterococcus spp. (9.3%) were isolated rarely. Among bacteria isolated in 1996 there were no ESBL strains while in 2004 ESBL strains accounted for 11.5% of all urinary bacteria. Klebsiella oxytoca (25%) and Klebsiella pneumaniae (20%) produced ESBL most frequently. ESBL production was less frequent in Escherichia coli (13.2%) and Proteus mirablilis (10%). In conclusion, among bacteria isolated from urine of children with urinary tract infections G(-) strains producing ESBL were encountered only in recent years.

Child↗

PubMed2003

A unique occurrence of a cerebral atypical teratoid/rhabdoid tumor in an infant and a spinal canal primitive neuroectodermal tumor in her father.

This report describes the clinical, pathological, immunohistochemical and genetic data of two rare malignant neoplasms of the central nervous system (CNS)--a cerebral atypical teratoid/rhabdoid tumor (AT/RT) in a 5-month-old girl and a spinal canal primitive neuroectodermal tumor (PNET) in her father. Despite aggressive treatment, both tumors were fatal, displaying extensive local recurrence and diffuse neoplastic dissemination. The paraffin-embedded tumor tissue samples were analyzed using a dual-color FISH with a locus specific LSI22q (BCR) probe. In the AT/RT tissue, a loss of BCR locus was observed in a significant proportion of the cells in contrast to the PNET specimen where the majority of nuclei did not reveal any loss of the BCR region. No mutations in exon 5 and no changes in SNP of intron 5 of hSNF/INI1 gene were found. In addition, analysis of loss of heterozygosity (LOH) was performed using a panel of 15 microsatellite markers of chromosome 22. No LOH were found in both tumor tissues. In both cases no constitutional mutations of gene TP53 were found. Analysis of the TP53 mutations in the tumor tissues revealed that the PNET, not the AT/RT tumor, was homozygous for a missense mutation at codon 175 (CGC ==> CAC). Thus, our findings emphasize the genetic differences between the two specimens and suggest that the occurrence of these two aggressive tumors of CNS in one family could be coincidental.

Adult↗

PubMedDate not supplied

[Rickets prophylaxis under current recommendations].

AIM OF THE STUDY: We analysed the compliance of current recommendations concerning rickets prevention in Poland. MATERIAL AND METHODS: The study group consisted of 65 infants hospitalised because of emergency problems. In each case, the medical history included prophylaxis of rickets and feeding pattern. In most cases (80%) we measured calcium, phosphate, and alkaline phosphatase in the serum. RESULTS: Vitamin D3 was overdosed in 70% of infants. 14% of children were diagnosed as rachitic in outpatient department before hospitalisation, but neither the clinical symptoms nor the laboratory test confirmed the diagnosis. This confirms the observation, that rickets is diagnosed too often, usually on the basis of isolated craniotabes in young infants. CONCLUSION: In the context of changing recommendations for prophylaxis of rickets, we recommend more careful prescribing of vitamin D3 preparations.

Drug Overdose↗

PubMedDate not supplied

[Antibiotics in lower respiratory tract infection].

THE AIM OF THE STUDY: Comparison of clinical outcome of lower respiratory tract infections in small children treated or not treated with antibiotics. MATERIAL AND METHODS: Eighty seven children aged from 2 months to 5 years admitted to hospital with mild to moderate bronchitis and/or pneumonia were randomly allocated to one of two groups: group A children were treated with antibiotics and group B patients were not. The children remained under close clinical observation. The clinical outcome was considered good if symptoms of the disease decreased after 72 hours. In case of no clinical improvement or worsening, the children from group B received antibiotics and in children from group A antibiotic therapy was changed. RESULTS AND CONCLUSIONS: There were no significant differences between the two groups in the course of the disease, the frequency of pulmonary complications and recurrence during one month of follow-up.

Administration, Oral↗

PubMedDate not supplied

[Erythema nodosum of tuberculous etiology in a 18 months old girl].

The authors report a case of an 18-months old girl with primary tuberculosis, where erythema nodosum was the main symptom. She received BCG vaccination on the first day of life according to the Polish vaccination programme. Although there was no postvaccinal scar when she was 12 months old, she was not revaccinated. On hospitalisation, the tuberculin skin test was strongly positive. The girl had a confirmed contact with tuberculosis. On the base of the anamnestic data and the clinical course, Erythema nodosum of tuberculous etiology was diagnosed and treatment was introduced. Erythema nodosum is not specific for tuberculosis but in the differential diagnosis tuberculosis should be taken into consideration.

Antitubercular Agents↗

PubMedDate not supplied

[Clinical value of neopterin. Part I].

Neopterin concentration can be used to detect the activation of the cellular immune system. Neopterin synthesis is the sum of all positive and negative regulating factors on the monocyte/macrophage populations activated by interferon-gamma, which is mainly produced by activated T lymphocytes. Neopterin can be determined in serum, plasma and other body fluids such as urine, cerebrospinal fluid, saliva, synovial fluid, ascitic fluid. The normal range of the neopterin concentration in serum or plasma is below 10 nmol/l. The applications for neopterin as a laboratory parameter for clinical diagnosis are: infections, autoimmune diseases, malignant diseases, posttransplant monitoring, blood transfusions, immunomodulatory therapy and treatment monitoring. Our own research results will be presented in part II of this study.

Autoimmune Diseases↗

PubMedDate not supplied

[Undernutrition in hospitalised children. Part I].

THE AIM OF THE STUDY: Determination of the incidence of undernutrition among children on admission to hospital. MATERIAL AND METHODS: In 818 patients aged l week to 20 years admitted to Paediatric Department from January to May 2004, the height and body mass was recorded and body mass index (BMI) was calculated. The incidence of undernutrition in this population was calculated. RESULTS: Body mass below 10th percentile was found in 158 children (19.3%). including 96 with body mass <3 percentile. Undernutrition was more frequent in children below 5 year of age (22.16%) than in the older ones (16.74%). CONCLUSIONS: Undernutrition among children admitted to hospital is relatively frequent and can make treatment more difficult and expensive.

Adolescent↗