Biomedical subjects

Karen R Dobkins

Publications and source records attributed to Karen R Dobkins.

15 recordsLinked to original sources

PubMed2006

Integration of one- and two-dimensional motion signals in infants: evidence from the barber-pole illusion.

Several previous studies in adults have investigated how one- and two-dimensional moving features are integrated into a coherent global motion percept by studying the "barber-pole illusion"; when a one-dimensional moving grating is presented within a rectangular aperture, the two-dimensional line terminators at the edges of the aperture bias the perceived direction of motion toward the longer axis of the aperture. In the current study, we used barber-pole stimuli to investigate the development of motion mechanisms that integrate one- and two-dimensional motion signals. Using a directional eye movement technique, we measured responses to obliquely moving gratings presented within horizontally vs. vertically oriented apertures, in infants (ages 2-5 months) and adults. For all ages, we found that horizontal eye movements were significantly stronger when gratings were presented within horizontal than within vertical apertures, as predicted by the barber-pole illusion. Additionally, we devised a way to infer the "effective shift" in eye movement direction produced by the barber-pole illusion. Using a simple motion integration model, effective shift values were then used to calculate the relative weightings of one- and two-dimensional motion signals to direction coding. The results show that by 2 months of age, infants integrate one- and two-dimensional motion signals, and that the relative weighting of one- and two-dimensional signals remains roughly constant from 2 months of age into adulthood.

Adult↗

PubMed2006

Image statistics of American Sign Language: comparison with faces and natural scenes.

Several lines of evidence suggest that the image statistics of the environment shape visual abilities. To date, the image statistics of natural scenes and faces have been well characterized using Fourier analysis. We employed Fourier analysis to characterize images of signs in American Sign Language (ASL). These images are highly relevant to signers who rely on ASL for communication, and thus the image statistics of ASL might influence signers' visual abilities. Fourier analysis was conducted on 105 static images of signs, and these images were compared with analyses of 100 natural scene images and 100 face images. We obtained two metrics from our Fourier analysis: mean amplitude and entropy of the amplitude across the image set (which is a measure from information theory) as a function of spatial frequency and orientation. The results of our analyses revealed interesting differences in image statistics across the three different image sets, setting up the possibility that ASL experience may alter visual perception in predictable ways. In addition, for all image sets, the mean amplitude results were markedly different from the entropy results, which raises the interesting question of which aspect of an image set (mean amplitude or entropy of the amplitude) is better able to account for known visual abilities.

Data Interpretation, Statistical↗

PubMed2005

Comparing the effects of auditory deprivation and sign language within the auditory and visual cortex.

To investigate neural plasticity resulting from early auditory deprivation and use of American Sign Language, we measured responses to visual stimuli in deaf signers, hearing signers, and hearing nonsigners using functional magnetic resonance imaging. We examined "compensatory hypertrophy" (changes in the responsivity/size of visual cortical areas) and "cross-modal plasticity" (changes in auditory cortex responses to visual stimuli). We measured the volume of early visual areas (V1, V2, V3, V4, and MT+). We also measured the amplitude of responses within these areas, and within the auditory cortex, to a peripheral visual motion stimulus that was attended or ignored. We found no major differences between deaf and hearing subjects in the size or responsivity of early visual areas. In contrast, within the auditory cortex, motion stimuli evoked significant responses in deaf subjects, but not in hearing subjects, in a region of the right auditory cortex corresponding to Brodmann's areas 41, 42, and 22. This hemispheric selectivity may be due to a predisposition for the right auditory cortex to process motion; earlier studies report a right hemisphere bias for auditory motion in hearing subjects. Visual responses within the auditory cortex of deaf subjects were stronger for attended than ignored stimuli, suggesting top-down processes. Hearing signers did not show visual responses in the auditory cortex, indicating that cross-modal plasticity can be attributed to auditory deprivation rather than sign language experience. The largest effects of auditory deprivation occurred within the auditory cortex rather than the visual cortex, suggesting that the absence of normal input is necessary for large-scale cortical reorganization to occur.

Adolescent↗

PubMed2005

Induction effects for heterochromatic brightness matching, heterochromatic flicker photometry, and minimally distinct border: implications for the neural mechanisms underlying induction.

Brightness induction refers to the finding that the apparent brightness of a stimulus changes when surrounded by a black versus a white stimulus. In the current study, we investigated the effects of black/white surrounding stimuli on settings made between red and green stimuli on three different tasks: heterochromatic brightness matching (HBM), heterochromatic flicker photometry (HFP), and minimally distinct border (MDB). For HBM, subjects varied the relative luminance between the red and green stimuli so that the brightness of the two colors appeared equal. For the two other tasks, matches were made based on minimizing red/green flicker (HFP) or the saliency of a red/green border (MDB). For all three tasks, the presence of black/white surrounding stimuli significantly altered red/green settings, demonstrating the existence of induction effects. These results are discussed in terms of which underlying color pathways (L+ M versus L-M) may contribute to induction effects for the different tasks.

Adaptation, Ocular↗

PubMed2004

Attentional effects on contrast discrimination in humans: evidence for both contrast gain and response gain.

In order to understand how attention affects visual processing, we investigated the degree to which attention effects can be accounted for by increases in the contrast gain of the contrast response function, CRF (represented by an increase in effective contrast) vs. increases in the response gain (represented by an overall amplification of response). To this end, we used a dual-task paradigm to compare psychophysical "threshold vs. pedestal contrast" (TvC) curves obtained under conditions of full- vs. poor-attention. The attention effect, defined as the ratio of thresholds for poor- vs. full-attention conditions, was roughly four-fold at a pedestal contrast of 0% (i.e., at detection threshold) and there was a significant decrease in attention effect with increasing pedestal contrast, from approximately ten-fold at the lowest non-zero pedestal contrast tested (0.25%) to three-fold at the highest pedestal contrast tested (64%). These findings are consistent with the existence of both contrast gain effects of attention (needed to account for the substantial attention effect at detection threshold and the decrease in attention effect with increasing pedestal contrast) as well as response gain effects of attention (needed to account for the fact that attention was beneficial across all pedestal contrasts-rather than harmful at some contrasts, as a pure contrast gain model would predict). The results of a model fitting Naka-Rushton CRF equations to the TvC data also support this conclusion. Here we found a two-fold increase in contrast gain and a five-fold increase in response gain in the CRF for the full-attention, as compared to the poor-attention, condition. Because pure contrast gain effects, on the order of two-fold, have been observed at early stages of visual processing (for example in areas V4 and MT), our psychophysical results suggest a hybrid model of attention; contrast gain control at an early stage of visual processing, followed by response gain control at a later stage.

Attention↗

PubMed2004

Pattern motion integration in infants.

To investigate the development of motion integration in infants, we used an eye movement technique to measure subjects' ability to track leftward versus rightward pattern motion in a stimulus consisting of a field of spatially segregated moving gratings. Each grating moved in one of two oblique directions, with the two directions interleaved across the display. When spatially integrated, pattern motion for these paired component motions was either rightward or leftward. To control for the possibility that horizontal eye movements elicited by this stimulus were due to the horizontal motion vector present in each obliquely moving grating, we also measured responses to a field where every grating moved in the same oblique direction. The difference in performance between the integration stimulus and this control stimulus was taken as a measure of integration. Data from 2-, 3-, 4-, and 5-month-old infants revealed significant motion integration, suggesting that higher order motion areas, such as the middle temporal area (MT) may develop at a relatively early age. In addition, the integration effect decreased consistently and significantly with age (p <.005), suggesting a reduction in the spatial extent of motion integration over the course of development.

Adult↗

PubMed2004

Attention enhances adaptability: evidence from motion adaptation experiments.

Several previous psychophysical and neurophysiological studies have investigated the separate effects of attention and adaptation on visual processing. Here, we investigated the combined effects of attention and adaptation on motion processing by measuring the effects of spatial attention on the duration of the motion after-effect (MAE) over a wide range of stimulus contrasts. MAE duration was compared between two conditions: full-attention, subjects were required to pay attention to the adapting motion stimulus, and poor-attention, subjects performed a difficult vowel detection task at the center of gaze and ignored the adapting motion stimulus. Attention was found to increase the MAE duration by a factor of 1.4, which was approximately constant over a wide range of stimulus contrasts (3.22-80.6%). Notably, this included contrasts for which the MAE duration had reached its asymptotic value. We show that a quantitative model based on known properties of directionally selective MT neurons can explain these results by assuming that attention enhances the effects of adaptation, a phenomenon we refer to as "adaptation gain". Specifically, attending to an adapting motion stimulus shifts the semi-saturation point (C50) of the underlying contrast response function (CRF) of motion detectors roughly 1.4-fold more to the right than does ignoring that same stimulus. By enhancing the effects of adaptation in this fashion, attention is predicted to enhance the adaptability of the visual motion system.

Adaptation, Physiological↗

PubMed2004

Attentional weighting: a possible account of visual field asymmetries in visual search?

Several previous visual search studies measuring reaction times have demonstrated scanning biases across the visual field (i.e. a tendency to begin a serial search in a particular region of space). In the present study, we measured visual discrimination thresholds for a target presented amongst distractors using displays that were short enough to greatly reduce the potential for serial (i.e. scanning) search. For both a motion and orientation task, subjects' performance was significantly better when the target appeared in the inferior, as compared to the superior, visual field (no differences were observed between left and right visual fields). These findings suggest that subjects may divide attention unevenly across the visual field when searching for a target amongst distractors, a phenomenon we refer to as 'attentional weighting'. To rule out the possibility that these visual field asymmetries were sensory in nature, thresholds were also measured for conditions in which subjects' attention was directed to the location of the target stimulus, either because it was presented alone in the display or because a spatial cue directed subjects' attention to the location of that target presented amongst distractors. Under these conditions, visual field asymmetries were smaller (or non-existent), suggesting that sensory factors (such as crowding) are unlikely to account for our results. In addition, analyses of set-size effects (obtained by comparing thresholds for a single target vs. the target presented amongst distractors) could be accounted for by an unlimited capacity model, suggesting that multiple stimuli can be processed simultaneously without any limitations at an early stage of sensory processing. Taken together, these findings suggest the possible existence of biases in attentional weighting at a late stage of processing. The bias appears to favor the inferior visual field, which may arise from the fact that there is more ecologically-relevant information in this region of space.

Attention↗

PubMed2003

Visual stimuli activate auditory cortex in deaf subjects: evidence from MEG.

Studies using fMRI have demonstrated that visual stimuli activate auditory cortex in deaf subjects. Given the low temporal resolution of fMRI, it is uncertain whether this activation is associated with initial stimulus processing. Here, we used MEG in deaf and hearing subjects to evaluate whether auditory cortex, devoid of its normal input, comes to serve the visual modality early in the course of stimulus processing. In line with previous findings, visual activity was observed in the auditory cortex of deaf, but not hearing, subjects. This activity occurred within 100-400 ms of stimulus presentation and was primarily over the right hemisphere. These results add to the mounting evidence that removal of one sensory modality in humans leads to neural reorganization of the remaining modalities.

Adult↗

PubMed2003

Independence of mechanisms tuned along cardinal and non-cardinal axes of color space: evidence from factor analysis.

Many previous studies employing paradigms such as adaptation, masking and summation-near-threshold have demonstrated the existence of separate mechanisms underlying the detection of the three cardinal axes of color space: L+M, L-M and S-(L+M). In addition, some studies have demonstrated the existence of higher-order mechanisms tuned to non-cardinal axes (which are made up of combinations of the cardinal axes). In order to address the issue of separate and independent color mechanisms further, here we applied factor analysis to contrast threshold data obtained from 41 subjects for nine different axes in color space (the three cardinal axes and the six non-cardinal axes midway between). In line with previous studies, the results of a three-factor analysis performed on contrast thresholds for the cardinal axes revealed independence across the three. However, in some of our factor analyses (for example, when a two-factor analysis was performed on the cardinal axes), intercorrelation was observed between L-M and S-(L+M) stimuli. With regard to higher-order mechanisms, our factor analyses revealed mechanisms selective for non-cardinal axes within the (L-M)/(L+M) and (S-(L+M))/(L+M) color planes, but not the (L-M)/(S-(L+M)) color plane. To ensure that the intercorrelation observed between L-M and S-(L+M) cardinal axes was not due to the particular stimulus parameters or testing measures employed, in three of our subjects we performed a "summation-near-threshold" experiment using experimental conditions nearly identical to those in the factor analysis experiments. In accordance with previous findings [Vision Research 39 (1999) 733], L-M and S-(L+M) stimuli were found to be separable in this analysis. This seeming discrepancy between the results of our factor analysis and those obtained from paradigms such as summation-near-threshold can be resolved by proposing that the mechanisms underlying detection of L-M and S-(L+M) stimuli are separable (as defined by the ability to isolate activity within each mechanism using select stimuli), yet nonetheless intercorrelated. Such intercorrelation could arise if these two mechanisms are limited by the same source of variability and/or subject to the same gain control.

Adolescent↗

PubMed2002

The effects of spatial attention on motion processing in deaf signers, hearing signers, and hearing nonsigners.

Visual abilities in deaf individuals may be altered as a result of auditory deprivation and/or because the deaf rely heavily on a sign language (American Sign Language, or ASL). In this study, we asked whether attentional abilities of deaf subjects are altered. Using a direction of motion discrimination task in the periphery, we investigated three aspects of spatial attention: orienting of attention, divided attention, and selective attention. To separate influences of auditory deprivation and sign language experience, we compared three subject groups: deaf and hearing native signers of ASL and hearing nonsigners. To investigate the ability to orient attention, we compared motion thresholds obtained with and without a valid spatial precue, with the notion that subjects orient to the stimulus prior to its appearance when a precue is presented. Results suggest a slight advantage for deaf subjects in the ability to orient spatial attention. To investigate divided attention, we compared motion thresholds obtained when a single motion target was presented to thresholds obtained when the motion target was presented among confusable distractors. The effect of adding distractors was found to be identical across subject groups, suggesting that attentional capacity is not altered in deaf subjects. Finally, to investigate selective attention, we compared performance for a single, cued motion target with that of a cued motion target presented among distractors. Here, deaf, but not hearing, subjects performed better when the motion target was presented among distractors than when it was presented alone, suggesting that deaf subjects are more affected by the presence of distractors. In sum, our results suggest that attentional orienting and selective attention are altered in the deaf and that these effects are most likely due to auditory deprivation as opposed to sign language experience.

Adult↗

PubMed2002

Visual field asymmetries for motion processing in deaf and hearing signers.

Recently, we reported a strong right visual field/left hemisphere advantage for motion processing in deaf signers and a slight reverse asymmetry in hearing nonsigners (Bosworth & Dobkins, 1999). This visual field asymmetry in deaf signers may be due to auditory deprivation or to experience with a visual-manual language, American Sign Language (ASL). In order to separate these two possible sources, in this study we added a third group, hearing native signers, who have normal hearing and have learned ASL from their deaf parents. As in our previous study, subjects performed a direction-of-motion discrimination task at different locations across the visual field. In addition to investigating differences in left vs right visual field asymmetries across subject groups, we also asked whether performance differences exist for superior vs inferior visual fields and peripheral vs central visual fields. Replicating our previous study, a robust right visual field advantage was observed in deaf signers, but not in hearing nonsigners. Like deaf signers, hearing signers also exhibited a strong right visual field advantage, suggesting that this effect is related to experience with sign language. These results suggest that perceptual processes required for the acquisition and comprehension of language (motion processing in the case of ASL) are recruited by the left, language-dominant, hemisphere. Deaf subjects also exhibited an inferior visual field advantage that was significantly larger than that observed in either hearing group. In addition, there was a trend for deaf subjects to perform relatively better on peripheral than on central stimuli, while both hearing groups showed the reverse pattern. Because deaf signers differed from hearing signers and nonsigners along these domains, the inferior and peripheral visual field advantages observed in deaf subjects is presumably related to auditory deprivation. Finally, these visual field asymmetries were not modulated by attention for any subject group, suggesting they are a result of sensory, and not attentional, factors.

Adult↗

PubMed2002

Chromatic input to motion processing in the absence of attention.

While several previous psychophysical and neurophysiological studies have demonstrated chromatic (red/green) input to motion processing, the nature of this input is still a matter of debate. In particular, recent controversy has developed regarding whether chromatic motion processing relies on lower-level processes [J. Neurosci. 14 (1994) 4854; 19 (1999) 6571] versus higher-level, attention- or salience-based mechanisms [Science 257 (1992) 1563; Proc. Natl. Acad. Sci. 96 (1999a) 8289; 96 (1999b) 15374]. In this study, we investigated the degree to which chromatic motion is influenced by attentional mechanisms by employing a dual-task paradigm, which allowed us to compare the strength of chromatic motion under conditions of poor versus full attention. Here, we found that for equiluminant red/green gratings, chromatic motion processing is as robust in poor, as in full, attention conditions. This lack of an attentional effect suggests that chromatic motion processing must rely, at least in part, on lower-level (i.e., pre-attentive) motion mechanisms. For non-equiluminant (e.g., red brighter than green) gratings, however, attention significantly modulates chromatic motion strength. Possible explanations for this latter result are discussed in the context of inherent salience differences between the bright-red and dim-green stripes of the heterochromatic grating.

Attention↗

PubMed2002

Individual differences in chromatic (red/green) contrast sensitivity are constrained by the relative number of L- versus M-cones in the eye.

Many previous studies have shown that the relative number of long-wavelength-selective (L) versus medium-wavelength-selective (M) cones in the eye influences spectral sensitivity revealed perceptually. Here, we hypothesize that the L:M cone ratio should also influence red/green chromatic contrast sensitivity. To test this, in each subject we derived an estimate of L:M ratio based on her red/green equiluminance settings (obtained with heterochromatic flicker photometry), and measured both red/green chromatic and luminance contrast sensitivity at different spatial and temporal frequencies. Factor analysis was applied to the data in order to reveal covariance between conditions. As expected, chromatic and luminance contrast sensitivity were found to be independent of one another, and no relationship was observed between L:M ratio and luminance contrast sensitivity. However, a significant relationship was observed between L:M ratio and chromatic contrast sensitivity, wherein subjects possessing the most symmetrical L:M cone ratios (i.e., near 1:1) appear to possess the relatively greatest chromatic contrast sensitivity. This relationship can be accounted for by a simple model based on the notion of random L- and M-cone inputs to the center and surround receptive fields of chromatic (L-M) mechanisms.

Adolescent↗

PubMed2002

Color-based motion processing is stronger in infants than in adults.

One hallmark of vision in adults is the dichotomy between color and motion processing. Specifically, areas of the brain that encode an object's direction of motion are thought to receive little information about object color We investigated the development of this dichotomy by conducting psychophysical experiments with human subjects (2-, 3-, and 4-month-olds and adults), using a novel red-green stimulus that isolates color-based input to motion processing. When performance on this red-green motion stimulus was quantified with respect to performance on a luminance (yellow-black) standard, we found stronger color-based motion processing in infants than in adults. These results suggest that color input to motion areas is greater early in life, and that motion areas then specialize to the adultlike state by reweighting or selectively pruning their inputs over the course of development.

Adult↗