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Biomedical subjects

K de Heer

Publications and source records attributed to K de Heer.

35 records · Page 2Linked to original sources
PubMed1981

[Mesenteric cysts (author's transl)].

Mesenteric cysts belong to the rare abdominal diseases. Histomorphologically, they are classified as cystic lymphangiomas. Even though most frequently localized in the mesentery of the small intestine, they can originate from any part of the abdominal cavity with two peritoneal linings. The content of the cysts is either serous or chylous possessing immunologic active proteins. This is demonstrated by its highly antibacterial activity. Whereas in children the onset of symptoms is acute due to intestinal obstruction, in adults it is mainly chronic abdominal pains without exact localisation and often in combination with a longstanding palpable tumour. In addition to routine procedure the diagnostics includes sonography, cavography and barium meal radiography of the stomach and intestines. In some cases, especially those with solid parts angiography and computer-tomography are of additional value. Surgery is the therapeutic method of choice. Preference is given to enucleation and resection with or without removal of part of the intestine corresponding to the mesentery baring the cyst. Drainage methods are of historical interest only. In our 9 cases (3 children and 6 adults) resection was performed in 7 and enucleation in 2 cases. The postoperative courses were uneventful.

Adolescent↗
PubMed1980

Protective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride in the rat.

The influence of cholestyramine and chenodeoxycholic acid on the induction of liver cirrhosis by carbon tetrachloride was investigated in the Wistar rat. The addition of 1.3% cholestyramine to the diet of the experimental animals inhibited to a large extent the induction of cirrhosis. While all the animals subjected to carbon tetrachloride exposure plus basal diet and those to carbon tetrachloride intoxication plus chenodeoxycholic acid diet developed cirrhosis, the morphological manifestation of cirrhosis occurred in the livers of only two out of 18 rats under carbon tetrachloride treatment plus cholestyramine diet. The administration of cholestryamine induces reactions which correspond to the physiological protective mechanisms of the liver. These are the bile acid binding, bacteriostatic, and microsomal enzymatic stimulating properties of cholestyramine.

Animals↗
PubMed1980

[Effect of cholestyramine and chenodesoxycholic acid on liver cirrhosis. An experimental study in rats].

The influence of cholestyramine and chenodeoxycholic acid on the induction of cirrhosis of the liver of the male Wistar strain rats was studied. The simultaneous dietary exposure of 1 g cholestyramine in 100 g diet prevented the development of cirrhosis induced by carbon tetrachloride. Whereas all the animals in the control group (CCl4-Exposure plus normal diet) developed cirrhosis, histologic examination showed cirrhosis in only 2 of 9 rats fed with diet containing cholestyramine. On the contrary, the exposure to chenodeoxycholic acid at a concentration of 1 g in 300 g diet potentiated the induction of cirrhosis. The experimental results support the clinical findings in which the administration of cholestyramine caused an improvement of liver function tests by cirrhosis.

Animals↗
PubMed1980

[Diagnostic value of selective parathormone determination in primary hyperparathyroidism].

The preoperative localisation of parathyroid adenomas is difficult even for an experienced surgeon. The rate of unsuccessful exploration of the neck lies between 2 and 18%. This is mainly due to to anomalies and extremely small adenomas. In vivo staining with toulidine blue, isotopic labelled selenmethionin or angiographic localisation are uncertain procedures. More accurate results can be achieved through fractionized measurement of parathyroid hormone with selective venous catheterization. This method was applied in 47 out of 71 patients with a correct localisation being achieved in 77%. In connection with subtle laboratory diagnosis and repeated assessment of serum calcium and phosphorus, this procedure is the method of choice. In cases with normocalcaemia surgical indication should be considered with due reservation despite positive localisation.

Adenoma↗
PubMed1979

[Chenodeoxycholic acid therapy and colorectal carcinoma--an experimental approach (author's transl)].

With respect to the potential significance of bile acids in the pathogenesis of colorectal cancer the effect of continuous oral administration of chenodeoxycholic acid--which is used for conservative therapy of radiolucent gallstones--on the rate of colonic tumors was examined. In rats treated with chenodeoxycholic acid a higher incidence of 1,2-dimethylhydrazine induced adenocarcinomas was detected. On the basis of these results it is postulated that all patients treated with chenodeoxycholic acid due to gallstones are registered systematically in order to gain definite information about its possible role as tumor promoter.

Animals↗
PubMed1979

[Surgical intervention in cold nodules of the thyroid gland (author's transl)].

In statistical analyses the rate of malignancy of solitary cold thyroid nodules is estimated between 3 to 50%. In our records the incidence of malignancy is 6,6%. Concerning the pathogenicity of these thyroid nodules no conclusions can be drawn which are only based on the results of such analyses. Each thyroid nodule has to be classified either according to its clinical and morphological characteristics or to its morphology alone. The condition for an optimal diagnosis and therapy is provided by the surgeon and pathologist being acquainted with the criteria for morphological classification or clinical data respectively.

Adenoma↗
PubMed1977

[Preoperative treatment of hyperthyroidism (author's transl)].

The preoperative preparation of hyperthyroidism requires the selective use of various drugs. As in the past, Plummer's iodine therapy takes precedence. Thyrostatics or beta receptor blockers, on the other hand, are only used in selected cases. The aim of preoperative preparation is euthyroidism. It is most rapidly and safely attained with Endoiodin (prolonium iodide) or combination of Endoiodine plus beta receptor blokkers. Thyrostatics appear to be less suitable for preparation, because they have a slow onset of action. Moreover, thyrostatics lead to densifications and adhesions of the thyroid gland capsule to the surrounding tissue, so that the preparation becomes complicated. 254 patients with hyperthyroidism and decompensated toxic adenoma were surgically treated without complications as a result of preparation with Endoiodin.

Adrenergic beta-Antagonists↗
PubMed1977

[An analysis of factors which can be influenced in geriatric surgery (author's transl)].

A retrospective study has been made of 1457 surgical patients over 70 years of age in three one-year periods (1960/61, 1969, 1973). While the average age remained 77, there has been changes in the frequency of diseases leading to hospitalisation. Degenerative lesions and casualties have increased. There are more elderly patients undergoing major surgery. On the contrary the mortality has reduced to 7.8%. The results of geriatric surgery are influenced by previous and concomitant diseases, the surgical lesion and the type of therapy. Suggestions for reducing the number of emergency operations are discussed. When necessary smaller palliative operation which improve the quality of life should be considered instead of major curative surgery. Surgery in the aged is a speciality and requires simultaneous consideration of various factors.

Age Factors↗
PubMed1977

[Cholecystectomy and experimental coloncarcinoma (author's transl)].

The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significant high rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gall bladder for some carcinogenic substances passing through the liver. The background of this experimental studies is the clinical findings that 10% of patients with carcinoma of the large bowels had a cholecystectomy previously.

Adenocarcinoma↗
PubMed1977

Cholecystectomy and carcinoma of the colon. An experimental study.

The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significantly increased rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH, 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gallbladder for some carcinogenic substances passing through the liver. The background of this experimental studies are the clinical findings that 10% of patients with carcinoma of the large bowel had previous cholecystectomy.

Animals↗
PubMed1977

[Colon carcinoma - duration of anamnesis and survival time (author's transl)].

In order to prove the hypothesis--short anamnesis; short survival time--the duration of the anamnesis and the period of survival of 230 patients with carcinoma of the colon were statistically mathematically and graphically investigated. No relationship in accordance with a rule was found between the duration of anamnesis and the time of survival. Curative surgery prolonged the period of survival significantly. The duration of the anamnesis depends on fortuitous factors and represents one of the stages of cancer. The delay after the first medical consultation is pointed out. It can be concluded that the resection of cancer in the early stage--early diagnosis--is for the survival decisive. The duration of the anamnesis is more important for the diagnosis than the surgical treatment and the prognosis.

Adult↗
PubMed1976

[A special closure system of the gastrointestinal tract of the rat (author's transl)].

As a result of animal experiments, morpho-histologic and surgical findings, the presence of a new closure system of the gastrointestinal tract is described. The mode of action is different from that of all the known muscle sphincters. It is found in the ascending colon of the rat and consists of a specially arranged and adjustable mucosal folds with aunique vascularisation. A functional unit which comosed of a pair of folds and a vascular plexus constitute the valvular mechanism. We, therefore, consider appropriate to call it the Angioplical Closure System. Surgical reversion of even a very small portion of the system causes a lethal ileus.

Ampulla of Vater↗