Search PubMed⌕ Search

Biomedical subjects

K Ziesenhenn

Publications and source records attributed to K Ziesenhenn.

At least 19 recordsLinked to original sources
PubMed1990

[Isovolemic hemodilution--an adjuvant treatment principle in patients with chronic cor pulmonale caused by chronic obstructive lung disease].

On the basis of 10 patients with chronic cor pulmonale due to chronic obstructive lung disease and secondary polyglobulia in a clinical and experimental study could be made evident that by limited isovolaemic haemodilution (haematocrit value of 0.58 +/- 0.03 reduced to 0.36 +/- 0.01) are to be expected a decrease of the total pulmonary-arterial resistance, a reduction of the mean pulmonary arterial pressure, an increase of the partial O2-pressure as well as an increase of the heart index. Analogically to this as a consequence of the improved rheologic conditions a clear involution of the clinical signs of a heart insufficiency developed. Complications were not observed. The technique of the limited haemodilution should find a broader use in the medical practice, taking into consideration the isovolaemia as adjuvant treatment principle for patients with the indication mentioned.

Blood Volume↗
PubMed1990

[Routine diagnosis in patients with latent sinus node syndrome].

The establishment of latent disturbances of the sinus node function is with high security successful by the determination of the sinus node recovery time only after medicamentous provocation with propranolol/atropin and verapamil, since the sensitivity of the determination of the sinus node recovery time is to small in the up to now usual way and in normal findings it is not able to exclude a sinus node dysfunction. The course of the investigation could be optimized according to the fact that despite complete medicamentous provocation only one running through stimulation is necessary without an endangering of the patient being the results. By this means of 75 patients 32 patients (43%) could be identified as sinus node syndrome of different degree of severity. On the basis of the improved ability of statement the determination of the sinus node recovery time for the diagnostics in patients with unclear syncopes and inconspicuous findings of the ECG should be performed only after a combined medicamentous provocation.

Aged↗
PubMed1987

[Physical exertion and the course of hepatitis].

Twenty-five patients with clinically and histologically verified acute hepatitis were subjected to a submaximal bicycle ergometer exercise during the first week after inpatient admission and afterwards subdivided into two groups. The first group maintained bedrest, and the other group trained for 30 minutes a day over six weeks at an exercise level amounting to 70% of the submaximal performance of the initial ergometry. Histological, clinical and laboratory results did not differ between the groups. It is concluded that immobilization for a short time only is indicated in acute hepatitis.

Acute Disease↗
PubMed1985

[Acute viral hepatitis and body loading--a self-excluding therapeutic principle?].

Of 27 patients with acute virus hepatitis 16 patients performed successfully a daily training programme during their stay in hospital. On the basis of both clinical and clinical chemical parameters in comparison to the control group of 10 patients who observed the conventional rest in bed the course of healing did not deteriorate. Also with regard to the late prognosis no higher rate of recidivation or chronification could be proved. Our examinations support the thesis that the demand of strong rest in bed is to be regarded as out of date in the treatment of acute virus hepatitis.

Adult↗
PubMed1983

[Effect of a bicycle ergometry training program in the acute phase of viral hepatitis on its late prognosis].

37 patients with clinically and histologically ascertained acute virus hepatitis (51% virus hepatitis B) underwent a bicycle-ergometric load a short time after admission to hospital and 17 of them were subsequently submitted to a training from twice a day to 30 minutes with 70% of the submaximal steady state effect. After their discharge from hospital all patients were repeatedly examined in the outpatient department for on an average 2.7 years; 20 patients (8 in the load group, 12 in the comparative group) were submitted to a liver biopsy on an average after one year. In 11 of the other patients the result of a histological examination of the liver from the end of the clinical treatment was present. The comparison of the training group and the control group showed nearly the same percentage of cures for the two groups as well as no transitions into chronic hepatitis in the training group. Also clinical and biochemical relapses did not appear in the load group. In a follow-up observation up to five years in the training group did not appear any disadvantage concerning the complete cure of virus hepatitis so that we apparently do not fear any negative sequels of physical activity in the acute phase of virus hepatitis. A forced immobilisation of the body--after proved ineffectiveness of diet and medicamentous treatment last support of the therapeutic regime--thus seems no more be indicated, since it is also accompanied by impairing reduction of the bodily function.

Acute Disease↗
PubMed1982

[Problems of so-called functional ECG changes].

It is reported on a 25-year-old African student with healthy heart in whom on account of an enlarged hepatologic diagnostics considerable changes of the ECG with repeated alteration between the ST-elevations and the T-negativations became manifest in the anterolateral BW-leads. In the otherwise inconspicuous findings functional changes of the ECG (early repolarization syndrome) with pronounced vegetative lability are concerned. The influence on the changes of the ECG by sympathicomimetics (isoproterenol test) may help to alleviate the diagnostics. In connection with diagnostic interventions the recognition and correct explanation of such ECG-findings is of decisive importance.

Adult↗
PubMed1981

[Diagnostic problems of diabetic nephropathy in elderly patients with diabetes from a clinical point of view].

The clinical findings of 28 diabetic females with suspicion of diabetic nephropathy were compared with the findings of 27 decreased female diabetics with ascertained diabetic glomerulosclerosis. In the two groups above all elderly female diabetics were concerned with an average duration of diabetes of more than 10 years. Of the parameters examined duration of diabetes and diabetic retinopathy still possessed the greatest diagnostic certainty. All the other symptoms (particularly proteinuria, hypertension) were only signs of reference. On account of the difficult differential diagnosis of the diabetic nephropathy an undiscriminating use of the notion should be avoided, above all then when a bioptical clarification is not possible.

Age Factors↗
PubMed1980

[Response of the heart rate and blood pressure to exertion - criterion for the differential therapy of hypertension].

In 37 patients with essential hypertension (WHO-stage I and II) ergometric examinations with submaximum stress were performed in sitting position for the judgement of the behaviour of heart rate and blood pressure (control group 20 clinically healthy persons). On account of the different behaviour of the heart rate the patients could be subdivided into 4 groups: A: normal heart rate in rest and under stress. B: heart rate increased only under stress. C: heart rate increased already in rest. Group D consisted of patients with hypertensive disturbance of the regulation (normal blood pressure immediately before ergometry). In 12 of the patients were also performed ergometric examinations under therapy: in group A the combined use of beta-receptor blocker and saluretic was necessary, in the groups B, C and D monotherapy with beta-receptor blocker was sufficient. The opinion is uttered that an abundant increase of blood pressure under stress in anamnestically known increased values of blood pressure in rest is also an indication to therapy as the appearance of very varying and on an average occasionally increased blood pressure values. In group A (normal regulation of frequency) by the beta-receptor blocker alone as a rule no sufficient effect is expected, the combination with a saluretic is necessary. In the other groups apart from the regulation of the blood pressure also the regulation of the heart rate is disturbed (among others reduction of the vagal inhibition of the heart, lack of training) and apart from the medicamentous therapy with beta-receptor blockers also a physical training is to be recommended. The different patterns of reaction which were to be proved by means of ergometry in patients with hypertension may in most cases be supposed already by the observation of the course and thus be included in the consideration concerning the differential therapy.

Adult↗
PubMed1980

[Overturned left type - manifestation of impaired intraventricular stimulus conduction or position dependent?].

When an overturned left type is present special criteria render possible the diagnosis of the left-anterior fascicular block. Among 7,687 ECG in 698 cases (9.1%) an overturned left type was to be seen. In accidental random test of 300 ECG with overturned left type in 183 cases (61%) a left-anterior fascicular block, in 111 cases (37%) an overturned QRS-left position were found. In 6 cases (2%) a decision was not possible. The left-anterior fascicular block increasedly appears with growing age beyond the 50th year of life. Hypertension (67%), chronic ischaemic heart disease (46%) clearly prevail in patients with left-anterior fascicular block, on the other and non-cardiovascular diseases with 58% more frequently appeared in the group of patients with overturned QRS-left-position. In this group hypertension occurred only in 33%, chronic ischaemic heart disease only in 14%.

Adult↗
PubMed1980

[Exercise ECG and serum enzymes in women using oral contraceptives].

In 45 women who in an average period of 5.6 years took oral contraceptives and who became evident in the transaminase screening a bicycle-ergometric load examination was carried out. At the same time before and after load estimations of enzymes (ALAT, ASAT, LDH, CK) were performed. Only in 4 women (8.9%) under load suspicious ECG-findings could be proved, which, however, could not be regarded as secure signs of ischaemia, but above all as falsely positive changes of the ECG in psychovegetative heart syndrome. The estimation of total enzyme activities did not achieve an additional gain of information.

Adult↗
PubMed1980

[About the clinical picture of pulmonary heart disease with special regard to correlations between pulmonary function and pulmonary hemodynamics (author's transl)].

After introducing heart catheterization especially the right heart catheterization according to Grandjean the direct measurement of right ventricular as well as pulmonary artery pressure has been made possible in a relatively simple manner. Thereby the diagnosis cor pulmonale chronicum can be secured or omitted respectively with high confidence. In this regard the exercise--induced increase in pulmonary artery pressure has evident importance especially in case of clinical uncertainty. But because the right heart catheterization is not available in each patient suffering from a pulmonary disease distinct parameters (PaO2, FEV1, pulmonary residual volume, ECG, heart rate) can be used for recognition of the not yet decompensated state of the pulmonary heart disease considering the clinical situation as well as the correlation calculations pointed out by us. With increasing number of implicated functional parameters the security of diagnosis raises.

Electrocardiography↗
PubMed1980

[Ergometric investigations with pressure measurements in the pulmonary arteria for judgment of the severity of the disease in patients suffering from left heart diseases (author's transl)].

Pressure measurements in the pulmonary artery were performed on 34 patients by intracardiac floating catheter during rest and under ergometer load of 51 Watt (corresponding to an oxygen consumption of 750 ml/min). 15 of the patients were suffering from myocardial infarction 4--6 weeks after admission, 12 from chronic coronary heart disease respectively angina pectoris and 7 from affection of the aortic valve. The pressure during rest ranged within the norm. Under load the patients suffering from myocardial infarction and coronary heart disease showed two forms of reaction: 1. moderate ascent of pressure up to 40 torr systolic and 15--18 torr diastolic (mean pressure 25--28 torr). 2. distinct ascent of pressure up to 50--60 torr systolic and 25--30 torr diastolic (mean pressure 36--42 torr). Evidence of latent pulmonary hypertension was irrespective of classification as myocardial infarction with or without complications. That demands regarding of central hemodynamics for the further course of rehabilitation more than hitherto.

Angina Pectoris↗
PubMed1979

[Bicycle ergometric testing in the acute phase of liver disease with particular reference to changes in serum enzymes].

It is reported on 20 patients (17 women, 3 men) who had undergone a bicycle-ergometric load in the acute phase of virus hepatitis (an average at the 16th day after admission to hospital). Among the significant changes of the activity the slight increase of SGPT 30 minutes after the end of the load as well as the clear decrease of the enzyme activities of SGPT and SGOT below the initial value 48 hours after load are particularly to be emphasized. LDH and CPK exhibited only insignificant changes of activity. It remains open to what extent there exists a connection between the ECG-changes proved in about half the women and the virus hepatitis as a cyclic infectious disease. In the 20 patients examined a clinically recognizable deterioration in the course of the disease by the load examination did not appear.

Acute Disease↗
PubMed1978

[Optimization of therapy using cardiac glycosides].

By the estimation of the serum glycoside concentration during the last years numerous new recognitions have been got, particularly concerning the pharmacokinetics of the heart glycosides, which increasingly will be reflected in the clinical practice. Apart from thoughts on pharmacokinetics the author adopts a definite attitude to glycoside tolerance, to the influence of age and bodyweight as well as to the importance of disturbances of the renal function. Moreover it is referred to new aspects in the dosage of heart glycosides, in which case the revision of the central therapy recommendations seems to be necessary.

Adult↗
PubMed1978

[Does abdoman cause ileus?].

On account of its favourable pharmacological properties Abdoman has proved in the treatment of patients with uncomplicated duodenal ulcer. On the basis of its pronounced motility inhibiting effect on the gastrointestinal canal it may be additionally used for the treatment of diarrhoea. It is reported on 5 patients in which under Abdoman therapy a paralytic ileus developed as severe complication, so that it must be warned of an uncontrolled prescription of abdoman concerning this indication. Abdoman should be used above all in juvenile patients, in which case particular attention must be paid to obstipation as most frequent side-effect.

Aged↗