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Biomedical subjects

K Zaydlar

Publications and source records attributed to K Zaydlar.

At least 37 records · Page 2Linked to original sources
PubMed1986

Colicinogeny in colorectal cancer.

Colicins, bacteriocins of Escherichia coli and related bacteria of Enterobacteriaceae family, form a very heterogeneous group of antibiotically active substances of proteinaceous material. Antitumorous effect of colicins have also been demonstrated experimentally. The large bowel has been found to be a site of their native action. Therefore, our work has been aimed at investigating colicinogenicity in patients with colorectal carcinoma. From a total number of 77 patients with colorectal carcinoma, colicinogenic Escherichia coli was found in 32 persons (41.6%), whereas from a total of 160 control clinically healthy persons, colicinogenic Escherichia coli was found in 102 persons (63.8%). The difference is statistically significant (p less than 0.05). The absence of colicinogenic Escherichia coli may be one of the factors contributing to the origin and development of colorectal carcinoma in some of the patients studied. Studies of patients with adenomatous polyps, members of colon cancer families, and large prospective studies of the general population will be necessary to prove this hypothesis.

Adult↗
PubMed1985

The effect of chronic exposure to 3.5 ppm NO2 on hormone levels and organ weights in rats.

Male Wistar rats were exposed continuously for 1 or 2 months to 3.5 ppm NO2. Levels of histamine and serotonin in lung, noradrenaline in hypothalamus, corticosterone and thyroxine in serum and catecholamines in the adrenals were estimated. No significant changes were observed in lung histamine and serotonin, serum corticosterone, or adrenal catecholamine levels; or in the weights of lung, spleen, adrenal glands, hypothalamus, liver and the whole body. The only significant change was a decrease in the concentration of hypothalamic noradrenaline after 2 months of exposure. The results suggest that prolonged exposure to 3.5 ppm NO2 does not result in changes in hormone levels, organ and body weights, and therefore does not precipitate pulmonary defensive reactions or non-specific stress response.

Adrenal Glands↗
PubMed1985

Cardiovascular response to hand-grip isometric exercise in healthy men. Noninvasive study.

Noninvasive polygraphic tracings obtained at rest and during isometric hand-grip exercise were analysed in 67 healthy subjects. The purpose of the study was to determine the response of noninvasive polygraphic parameters to isometric exercise. During the third minute of sustained squeezing of a balloon dynamometer (30% of maximal voluntary contraction) a significant increase occurred in heart rate (+16.8 +/- 10.7 beats/min) an increase in both systolic and diastolic blood pressure (+3.4 +/- 1.6 kPa and 2.6 +/- 1.7 kPa respectively), increase in apexcardiographic index 100.a/D (+14.5 +/- 15.0% "D" amplitude), decrease of diastolic amplitude time index square root 2-c/(2-0) X (a/D) (-20.1 +/- 26.5), shortening of pulse transmission time (-0.006 +/- 0.005 s) and prolongation of cardiac cycle length corrected for left ventricular ejection time (+0.011 +/- 0.010 s) discussed. All these changes were statistically significant.

Adult↗
PubMed1985

Is there an increased risk of colorectal cancer after cholecystectomy?

The incidence of cholecystectomy was not higher in 525 colorectal cancer patients than in subjects without colorectal cancer of the same age and sex living in the same region. If we did not include the persons who underwent cholecystectomy 1 or 2 years before the diagnosis or the examination was made, the number of cholecystectomy patients was the same in both groups. Right-sided and left-sided localizations of colon cancer after cholecystectomy did not differ from those without cholecystectomy. The tendency to right-sided colon cancer in women who have undergone cholecystectomy was not significant. Patients after cholecystectomy have no higher risk of colorectal cancer than persons without cholecystectomy.

Adult↗
PubMed1985

A microassay for tetrazolium-reductase activity of polymorphonuclear leukocytes--comparison with a test-tube technique.

A micromethod for quantitative INT test is described to assay the activity of human peripheral blood PMNL. PMNL are obtained from a pellet after the separation of mononuclear cells. The test is performed in microtiter plates with 96 wells. The estimation of the activity is based on the colour change following the INT reduction to formazane. As a stimulating agent starch (rice species--Amylum oryzae) or zymosan is used. Absorbance alternations are measured using a microplate reader (e.g. MR 580, Dynatech). Conditions necessary for standard results (i.e. PMNL concentration, type and concentration of stimulating agent, incubation time, sedimentation time for PMNL isolation) were verified experimentally. Blood samples of 60 blood donors were simultaneously tested by the micromethod and the test-tube method. The statistical analysis (F-test of homogeneity of variances, t-test with paired observations, correlation coefficient of tightness of dependence) proved that the results of the micromethod were comparable to the test-tube assay. The advantages of the micromethod are as follows: low blood consumption, possibility to perform more parallel examinations of the same sample, and to test more samples at a time, standard and highly reproducible results, saving of reagents, reduction of labour time, possibility of some further automation.

Adult↗
PubMed1983

The effect of chronic exposure to 100 ppm carbon monoxide on brain biomines, serum corticosterone and organ weights in rats.

The effect of chronic exposure to 100 ppm (0.01%) CO on pituitary-adrenal activity was evaluated by measuring serum corticosterone and brain bioamine levels in the rat. Exposure to CO for 1 month induced a decrease in the brain serotonin levels. Serum corticosterone, brain dopamine and noradrenaline as well as the weight of the adrenal glands, lungs, spleen and liver were unchanged. After two months of exposure, serum corticosterone and brain serotonin levels were elevated and the liver weight was significantly lower. This suggests that at this chronic low concentration CO acts as a stressor, and the organism initiates a general defensive reaction. The effect of CO on the pituitary-adrenal axis could be mediated by a central neuronal pathway.

Animals↗