Search PubMed⌕ Search

Biomedical subjects

K Zawilska

Publications and source records attributed to K Zawilska.

85 records · Page 5Linked to original sources
PubMedDate not supplied

[Continuous intravenous infusion versus intermittent administration of streptokinase in patients with deep venous thrombosis of the lower extremity].

In a multicenter randomized trial, the efficacy and safety of two streptokinase (SK) dosage regimens have been evaluated in patients with proximal deep vein thrombosis of inferior limbs. Twenty-nine patients received SK by a continuous intravenous infusion (250,000 IU as initial dose, 100,000 IU/h as maintenance dose), and 26 patients were treated with intermittent SK administration (500,000 IU as initial dose, followed by 250,000 IU every 12 h). Thrombolytic therapy was continued for 4 days, then the patients received heparin for 5 days and oral anticoagulant for 3 months. The results of treatment as judged by phlebographic examinations were similar in the two groups. Complete, substantial or partial thrombolysis was achieved in 52% of patients in the continuous infusion group and in 58% of patients in the intermittent treatment group. During SK administration, major bleeding complications occurred in 6 patients treated by continuous infusion and in 2 of the second group. The results showed that the intermittent SK administration is as effective and safe as the method of continuous SK infusion in the treatment of deep vein thrombosis.

Adolescent↗
PubMedDate not supplied

[Platelet function in acute myeloid leukemia. II. Aggregation of isolated platelets].

In 22 patients with acute myeloid leukaemia (17 cases of myeloblastic leukaemia, 4 cases of myelomonocytic leukaemia and 1 case of undifferentiated-cell leukaemia) platelets were isolated from the plasma by the method of Nicholls and Hampton as modified by Levy-Toledano by centrifugation in albumin gradient. The aim of platelet isolation was their "concentration" in cases of thrombocytopenia to values making possible aggregation tests, and platelet separation from the influence of plasma factors. Then aggregation of isolated platelets caused by ADP was studied. In 16 out of 22 patients a fall of aggregation was observed, with the mean values of aggregation rate and intensity were significantly lower. Parallelly done determinations of aggregating activity released from the platelets by thrombin showed lower values as compared with platelets from healthy subjects. In might be thought, in this connection, that the demonstrated reduction of isolated platelets is associated with a diminution of the nucleotide pool or disturbances of the platelet release reaction. The disturbances of the platelet release reaction. The disturbances of aggregation of isolated platelets and reduction of the aggregating activity were most pronounced in acute myelomonocytic leukaemia.

Adolescent↗
PubMedDate not supplied

[Activation of the fibrinolytic system following subcutaneous administration and inhalation of heparin].

Heparin was administered to 113 patients at risk of thrombosis classified to abdominal surgery either alone (subcutaneously or in inhalation) or in combination with anabolic steroid (nandrolone). No pharmaco-prophylaxis was used in 10 patients. On the day of surgery, heparin activated plasma fibrinolytic activity, prior to an introduction to anesthesia. Measurements of euglobulins clot lysis have shown an increase in endogenous fibrinolytic activity dependent and independent on Hageman's factor and an increase in exogenous fibrinolysis, tested after venous stasis was produced. Heparin had profibrinolytic activity, stimulating plasminogen activators in the blood plasma without the signs of hyperplasminemia. Fibrinolytic system response was the same following subcutaneous injection and heparin inhalations. Administration of heparin combined with anabolic steroid has no additional effect on plasma fibrinolytic activity.

Administration, Inhalation↗