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K Yokote

Publications and source records attributed to K Yokote.

51 records · Page 3Linked to original sources
PubMed1992

[Improvement of respiratory function with weight reduction in obese elderly].

The patient was a 74-year-old woman who had been obese since age 18. Her obesity was refractory to dietary manipulation. She had been suffering from increasing dyspnea for several months and eventually could not even move. She was admitted to a hospital and diagnosed as having heart failure. Although her cardiac function recovered with medical treatment, her symptoms did not improve. The patient was then sent to our hospital. On admission, her height and weight were 149 cm and 81.9 kg, respectively, yielding a body mass index (BMI) of 36.6 kg/m2. Arterial blood gas analysis in room air revealed hypoxemia and an apnea index of 27 per hour. She was given a daily 500-1000 kcal diet. After four months of treatment, her weight decreased to 65 kg with a BMI of 29.3 kg/m2. Weight reduction together with the usage of progesterone-derivatives resulted in marked improvement of sleep apnea. The apnea index decreased to 3/h and arterial blood gas values normalized. This patient seemed to have suffered from both obesity hypoventilation syndrome and sleep apnea syndrome. Improvement of respiratory function was achieved through relief of airway obstruction and weight reduction, with activation of the respiratory center due to progesterone treatment.

Aged↗
PubMed1992

Atherosclerosis from a viewpoint of arterial wall cell function: relation to vitamin E.

Vitamin E affects many key events in atheromatous lesions. Inhibition of EC injury and platelet aggregation was already reported. Foam cell formation must be inhibited according to the data presented by us and other speakers. However, effects on cell proliferation of SMC are paradoxical. The in vivo effects will be dependent on the effective concentration of vitamin E in the loci.

Animals↗
PubMed1991

Dumbbell neurogenic tumor of the mediastinum: a report of three cases undergoing single-staged complete removal without thoracotomy.

Of a total thirteen patients who underwent surgery for a neurogenic tumor in the posterior mediastinum 4 (30.8 per cent) presented with dumbbell type development of the tumor. Along with a comparatively greater incidence in the number of cases of dumbbell neurogenic tumors in the posterior mediastinum, resection has also recently become more popular, necessitating the establishment of a standard operative approach for this type of tumor. We successfully removed dumbbell neurogenic tumor from the posterior mediastinum in our 3 most recent cases via a dorsal approach by virtue of a laminectomy and resection of a small portion of the neighbouring rib root without opening the parietal pleura at all. These three patients were a 14 year old female, a 54 year old male and a 68 year old female, respectively, and the largest diameter in cm and level of origin of the tumors were 5.5 at Th 1 in case 1, 3.0 at Th 2 in case 2 and 3.7 at Th 11 in case 3. The operative approach described herein was easy to perform, felt secure and was less invasive and better tolerated by the patients than the thoracotomy approach. Avoiding a thoracotomy in such cases has many advantages to enumerate, but does not seem to have been clearly aimed at by others to date. We therefore propose our technique as a standard approach for dumbbell neurogenic tumors in the posterior mediastinum.

Adolescent↗
PubMed1990

Inheritable abnormal lipoprotein metabolism in Werner's syndrome similar to familial hypercholesterolaemia.

Studies were made on the abnormality of lipoprotein metabolism and its cause in 10 patients with Werner's syndrome. Seven of the 10 patients had hypercholesterolaemia (above 250 mg dl-1). Six of the seven patients with hypercholesterolaemia had thickened Achilles' tendons (greater than 9 mm). A significant positive correlation (P less than 0.01) was found between the serum total cholesterol levels and the thickness of Achilles' tendons in these 10 patients, suggesting that the substance precipitated in the thickened tendons is derived from serum cholesterol. Some first-degree relatives of three patients with both hypercholesterolaemia and xanthoma-like thickening of Achilles' tendons also suffered from hypercholesterolaemia. Moreover, the low density lipoprotein (LDL) receptor activities in peripheral lymphocytes of five patients with both hypercholesterolaemia and xanthoma-like tendons were significantly (P less than 0.001) lower than those of controls, whereas the LDL receptor activities of two patients without hypercholesterolaemia were almost the same as those of controls. These findings suggest that, at least these five patients with lower lymphocyte LDL receptor activities, and probably another patient with both hypercholesterolaemia and xanthoma-like thickening of Achilles' tendons suffered from familial hypercholesterolaemia (FH). If this is the case, this high frequency of association of Werner's syndrome with FH (in six of 10 patients) suggests some relationship between these two diseases.

Achilles Tendon↗
PubMed1990

[Results of pulmonary resections in elderly patients with primary lung cancer].

Forty-one patients over the age of 70 years, who had been operated upon for a primary lung cancer during 13 years until August, 1988, were reviewed. There were 32 males and 9 females, among whom the oldest was an 85-year-old male. These patients composed of 28.7% of the patients who had undergone a resectional lung surgery due to a primary lung cancer during the same period of time. These included 26 patients of stage I, 11 of IIIA, 3 of IIIB and 2 of IV. Twenty-two of them were with a squamous cell carcinoma, 18 with an adenocarcinoma, and one with a small cell carcinoma. Thirty-two patients underwent a lobectomy, including two undergoing a sleeve lobectomy. Three patients underwent a left pneumonectomy, and seven underwent a segmentectomy or a wedge resection. A combined chest wall resection was done in 5 of them. One patient underwent the second surgery for a metastasis to the contralateral lung following a left pneumonectomy. Our safety criteria of pulmonary functions for surgery were as follows; a predicted postoperative %VC greater than 40% for any type of pulmonary resection, a preoperative FEV1.0 greater than 1,000 ml for lobectomy and that greater than 1,300 ml for left pneumonectomy. These criteria were identical to those for patients younger than 70 years of age. But some patients even with respiratory functions slightly less than these lower limits did tolerate lobectomies or pneumonectomies. The latter patients, however, cleared what we call "one-flight test" as well as the other patients did.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1989

[Hyperlipidemia as a complication of patients with Werner's syndrome].

Serum lipid levels and the roentgenograms of the Achilles' tendon were examined in ten patients with Werner's syndrome. Seven of these ten patients showed serum total cholesterol levels of more than 250 mg/dl and six of the seven patients had thickened Achilles' tendons of more than 9 mm. Significant positive correlation was found between serum levels of total cholesterol and the thickness of the Achilles' tendon in these ten patients, suggesting that substance(s) precipitated in the thickened tendon may have been derived from serum cholesterol. Moreover, some relatives suffered from hypercholesterolemia in three of the six patients with thickened Achilles' tendons, suggesting that at least these three patients may also suffer from familial hypercholesterolemia (FH). Because of this surprisingly high frequency of concurrence of Werner's syndrome and FH (three to six out of ten patients), it is possible that an abnormal lipid metabolism similar to FH may be due to some intrinsic abnormality of patients with Werner's syndrome.

Adult↗
PubMed1987

The role of mediastinal and multi-organ CT scans in staging presumable surgical candidates with non-small-cell lung cancer.

In order to evaluate the role of CT scan and bone scan in staging patients with non-small-cell lung cancer presumably indicated for surgery, 70 consecutive patients who underwent thoracotomy were reviewed. Most of them received mediastinal and multi-organ (brain, liver and adrenal) CT scans and a bone scan. In the most recent 40 of the 70 patients, CT findings of the mediastinal lymph nodes were compared to the pathology following complete sampling. The overall accuracy of the mediastinal CT was 60.0 per cent (12 true positive and 12 true negative), but the negative predictable value was 12/(12 + 3) or 80.0 per cent, whereas 3 were false negatives though they showed an acceptable postoperative course. Sixteen out of 21 patients with one, or at the most, three enlarged nodes detected on CT also did well postoperatively and retrospectively, were considered not to have required mediastinoscopy. A group of patients showing no, or at the most, three enlarged mediastinal lymph nodes on CT may be considered as candidates for surgery even without mediastinoscopy. Multi-organ survey by means of CT was believed cost-ineffective and omittable. Bone scan however, retrospectively detected three true positives among 20 patients with a positive uptake, so that it cannot be omitted out of hand, though further examination of this point is required.

Aged↗
PubMedDate not supplied

Wernicke encephalopathy: follow-up study by CT and MR.

A follow-up study by CT and MR of a case of Wernicke encephalopathy is reported. In the early stages, CT and MR revealed a characteristic topographical distribution of lesions in the midbrain, pons, and thalami. In the later stages, MR showed atrophy of the mamillary bodies and midbrain tegmentum and dilatation of the third ventricle. Both CT and MR are useful tools for the diagnosis of Wernicke encephalopathy in the early stages.

Female↗