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Biomedical subjects

K Yokochi

Publications and source records attributed to K Yokochi.

At least 91 records · Page 5Linked to original sources
PubMed1981

[Two-dimensional echocardiographic diagnosis of aortic arch by suprasternal approach (author's transl)].

Two-dimensional echocardiographic studies of the aortic arch and proximal descending aorta were performed in 6 cases with coarctation of the aorta, 40 normal subjects and 9 cases of coarctectomy approached by the suprasternal notch. In cases with the normal aortic arch and proximal descending aorta, the ascending aorta, aortic arch, descending aorta and right pulmonary artery were visualized clearly. The diameter of the aortic lumen is consistent throughout the plane of the scan. The origins of the left carotid artery and the left subclavian artery were seen clearly. In 3 of 7 normal newborns a localized area of a slightly aortic narrowing (diameter of aortic narrowing area / diameter of proximal descending aorta greater than 0.75) was visualized. In 5 of 6 cases with coarctation of the aorta a localized area of an aortic narrowing distal to the origin of the left subclavian artery is visualized which corresponded to the angiographic appearance of the coarctation. In 1 of 6 cases with coarctation of the aorta a more diffuse area of aortic obstruction beginning from distal portion of the left carotid artery to distal portion of the left subclavian artery was visualized. In this case, aortic valve stenosis, ventricular septal defect, patent ductus arteriosus, and hypertrophy of the interventricular septum and left ventricular posterior wall were associated. In 9 coarctectomy cases a localized area of an aortic narrowing distal to the origin of the subclavian artery was enlarged after operation. Two-dimensional echocardiogram approached by the suprasternal notch may offer a useful noninvasive method for direct visualization of the aortic arch and proximal descending aorta.

Adolescent↗
PubMed1978

[Clinical studies of PC-904 in pediatrics (author's transl)].

PC-904 was administered to 24 patients: urinary tract infections (7 cases), bronchitis (2 cases), pneumonia (3 cases), brain abscess (1 case), septicemia and the suspected cases (10 cases), and buttock abscess (1 case). The daily dosage varied from 60 to 223.4 mg/kg and averaged 86.9 mg/kg. The drug was administered three times a day by 1-hour drip infusion, and the duration of the treatment averaged 11 days. Clinical results were obtained as excellent responses in 5 cases, good in 13, poor in 4, and unknown in 2, giving 75% of the clinical effectiveness. Bacteriological responses were excellent in 7, good in 2, poor in 2, and unknown in 13, and the overall effectiveness was evaluated as excellent in 2, good in 17, and unknown in 5. Antibacterial activities against clinically isolated bacteria were examined. MIC values of PC-904 were over 100 mg/ml 1 strain of E. coli and 2 strains of Klebsiella, however excellent sensitivities were observed in 3 strains of Ps. aeruginosa and MIC values varied 1.56 to 3.12 microgram/ml at 10(8) of inoculum size and 0.78 to 1.56 microgram/ml at 10(8). As to side effects, diarrhea was observed in 1 case, rash in 2, lowering ob blood pressure in 2, elevation of GOT in 1, and elevation of LDH in 2. Abnormal elevations of GOT (10 cases), GPT (5 cases), A1-P (1 case), LDH (7 cases), and BUN (1 case) were noticed in other patients, but it was considered to be due to underlying diseases.

Adolescent↗
PubMedDate not supplied

Motor function of infants with spastic hemiplegia.

The motor function of 25 children with spastic hemiplegia was examined retrospectively using videotapes recorded at 2-8 months of age. Many infants showed deficient forward movement of the arm and deficient opening of the hand on the affected side. At 7 and 8 months of age, whether the hand was semiflexed or clenched was correlated with the later upper extremity function. In the prone position, most could support their weight on the flexed arm on the affected side. In the supine position, half of the infants could not extend the knee on the affected side. At 2 months of age, asymmetry of the upper and lower extremity movements was not identified. Persistent primitive reflexes and abnormal truncal muscular tone were not recognized in the hemiplegic infants, and did not seem to be signs predicting hemiplegic cerebral palsy.

Cerebral Palsy↗
PubMedDate not supplied

Tongue thrust swallowing in severely physically disabled children.

In five patients with severe physical and mental disabilities, a feeding pattern with tongue thrust was assessed videofluoroscopically. Forward and backward movements of the tongue associated with movements of the mandible propelled the bolus, and the insufficiently formed bolus spilled out anteriorly and laterally in part. The swallowing reflex was accompanied by tongue thrust. After the reflex, a part of the bolus frequently remained on the vallecula and pyriform sinuses. The suckle pattern shown by infants is suggested to remain and develop into this feeding pattern with tongue thrust.

Adolescent↗
PubMedDate not supplied

Arthrogryposis multiplex congenita: histochemical study of biopsied muscles.

Morphometric analysis was performed after histochemical staining on 12 biopsied muscles of the affected limbs from 12 patients with arthrogryposis multiplex congenita. Except for one muscle, samples demonstrated variation in fiber size associated with abnormal fiber type distribution suggesting abnormal innervation: large groups of atrophic fibers in one muscle, either type 1 or 2 fiber predominance with occasional fiber type grouping in five, a complete lack of type 2 fibers in one, type one fiber atrophy in one, both type 2A and 2B fiber atrophy in two, and increased number of type 2C fibers in four. In most patients with arthrogryposis multiplex congenita, a defect in neural influence on the developing muscles may be responsible for the absence or maldevelopment of some muscle groups. Underdeveloped muscles are then assumed to induce imbalance of agonists and antagonists resulting in permanent contractures.

Adolescent↗
PubMedDate not supplied

Gross motor patterns in children with cerebral palsy and spastic diplegia.

Rolling, sitting, and crawling patterns were motoscopically analyzed in 72 children with cerebral palsy and spastic diplegia; the relation between these patterns and the severity of the locomotive disability was studied. In rolling, trunk rotation and elbow support were difficult for the most severely diplegic children. When sitting, most patients had a between-heel sitting pattern in which the thighs were adducted and the knees were flexed. When crawling, the reciprocal thigh movements were insufficient and accompanied by lateral bending of the trunk in many patients. In the more impaired patients, the thighs supported the weight in flexion and did not move reciprocally. Creeping on the elbows without reciprocal leg movements was demonstrated in the most severely affected children after 2 years of age.

Cerebral Palsy↗
PubMedDate not supplied

Paroxysmal ocular downward deviation in neurologically impaired infants.

Thirteen neurologically impaired children with paroxysmal ocular downward deviation were studied. The eye movement accompanied downward movement of the upper eyelid; there was no coincident paroxysmal discharge on electroencephalography. The ocular abnormality was observed in infancy, predominantly in preterm infants, and spontaneously resolved in many of them. All patients had spastic quadriplegia or diplegia and mental retardation. Many children also had cortical visual impairment. This eye movement abnormality, not reported previously, should be considered to be a neurologic sign in brain-damaged infants with cortical visual impairment.

Age Factors↗
PubMedDate not supplied

Magnetic resonance imaging in athetotic cerebral palsied children.

The magnetic resonance findings in 22 children with athetotic cerebral palsy were studied. Sixteen had perinatal asphyxia, two had neonatal jaundice, and four had no association with predisposing conditions. In six of the children, symmetrical high intensity areas were found in both the thalamus and putamen in T2-weighted images. In five children they were seen only in the thalamus, and in another one only in the putamen. In six children, symmetrical periventricular high intensity areas were seen. In seven of the subjects, no abnormal magnetic resonance findings were seen. Magnetic resonance lesions, possibly caused by asphyxia, were found in the basal ganglia, thalamus and/or cerebral white matter in 14 of 16 children. Three children with lesions only in the cerebral white matter had mild motor abnormality, and six children with lesions in both the thalamus and putamen did not have mild abnormality.

Athetosis↗