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Biomedical subjects

K Yata

Publications and source records attributed to K Yata.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Proliferative vitreoretinopathy treated with daunorubicin].

Nine eyes with severe proliferative vitreoretinopathy underwent vitrectomy and infusion of Daunorubicin to prevent reproliferation. In 5 eyes (56%) the retina was reattached. In 4 eyes redetachment occurred because of reproliferation or incomplete sealing of the break. After a second vitrectomy, complete reattachment of the retina was obtained eventually in all eyes including one eye with silicone oil tamponade. As postoperative complications, conjunctival dehiscience occurred in 3 eyes. In two of the 3 eyes scleral buckling occurred, and orbital cellulitis occurred in one eye. Daunorubicin seemed to be effective to suppress reproliferation, but care should be taken to avoid postoperative complications.

Adolescent↗
PubMed1991

[Recurrent hyperkalemia in the course of rheumatoid arthritis--a case report].

A 69-year-old woman with advanced rheumatoid arthritis (RA) suffered two episodes of hyperkalemic hyperchloremic metabolic acidosis (HCMA). Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were markedly suppressed in the first episode occurring in paralell with the administration of metoprolol during piroxicam and lobenzarit (CCA) therapy. Rechallenge with diclofenac sodium and CCA lead to the second hyperkalemia, but no significant suppression of the renin-aldosterone axis was seen at that time. This suggests that the different mechanisms contribute to the development of these episodes, including the tubulo-interstitial injury which is not uncommon in RA. The combined use of nonsteroidal anti-inflammatory drugs (NSAIDs) and beta-adrenergic blockers may increase the risk of life-threatening hyperkalemia through their suppressive effect on the renin-aldosterone system, whereas the concomitant administration of CCA with NSAIDs through the impairment in the renal tubular function. These drugs should be most carefully given to patients with a latent defect in renal potassium excretion.

Adrenergic beta-Antagonists↗
PubMed1990

Diabetes as risk factor of cataract: differentiation by retroillumination photography and image analysis.

We performed an epidemiological study to identify risk factors of cataract based on 2,243 subjects who underwent a general health checkup. Each subject underwent a 75-gram oral glucose tolerance test and blood chemistry analysis. The prevalence rate of cataract was higher in diabetic subjects in their 50s than in nondiabetics in the same age range (p less than 0.01). The incidence of vesicular and radial lens opacity was higher in diabetics than in nondiabetics (p less than 0.05).

Adult↗
PubMed1989

[The measurement of hepatic circulation before and after orthotopic liver transplantation in dog--by using transit-time blood flow meter and H2 clearance method].

Orthotopic liver transplantation was successfully carried out in 40 mongrel dogs, in which hepatic circulation was investigated before and after grafting. Blood flows in hepatic artery, portal vein and intrahepatic inferior vena cava were measured by using transit-time ultrasonic blood flow meter and regional tissue blood flow was determined by hydrogen gas clearance method. Before transplantation the mean blood flows were 234 +/- 95mg/min in portal vein, 118 +/- 76ml/min in hepatic artery and 291 +/- 103ml/min in inferior vena cava in 40 recipients. The blood flow ratio of portal vein and hepatic artery was 2.9 +/- 2.2. The mean regional blood flow of the liver was 63 +/- 24ml/min/100g. After transplantation, the mean blood flows decreased to 189 +/- 86ml/min in portal vein, 77 +/- 51ml/min in hepatic artery and 179 +/- 111ml/min in inferior vena cava and the regional tissue blood flow was 57 +/- 25ml/min/100g. Hepatic arterial flow decreased by 37 percent after transplantation, however, portal venous flow decreased by 24 percent and the regional blood flow decreased by 9 percent after transplantation of the liver. These data suggested that the microcirculation of the liver was slightly disturbed after liver transplantation in dog, which was in part due to the decreased blood flows of the hepatic artery and portal vein.

Animals↗
PubMed1987

Epidemiology of cataract--clinical evaluation with retro-illumination photography.

Retro-illumination photography was utilized for epidemiological studies of cataract. Diagnosis of cataract was made by the existence of shadows on the photographs obtained. In the prevalence study, prevalence rate of cataract was 35.7% in all (30.2% in male and 45.1% female) 1,017 persons (643 males and 347 females). Prevalence rates were always higher in females than in males, and in diabetics as compared with non-diabetics, in all decades of life. The progression study in 338 persons (144 males and 194 females) revealed that maturing courses of cataract were most rapid in diabetic females in the fifth to seventh decades of life.

Adult↗
PubMed1982

[Antitumor effect of levamisole].

The inhibition of MH134 tumor growth which was transplanted into foot-pad of C3H mice was observed in levamisole treatment. The inhibitory mechanism of tumor growth by levamisole was studied by the transfer of spleen cells. It was suggested that activated macrophage within spleen cells by levamisole might be played a major role for inhibition.

Animals↗
PubMed1980

Immunoregulatory T-cell function in acute and chronic liver disease.

The suppressor function of T cells separated from the peripheral blood lymphocytes of patients with acute or chronic liver disease was evaluated by using, as an indicator system, pokeweed mitogen-induced immunoglobulin synthesis in vitro. Suppressor activity of T cells was enhanced during the recovery phase in 13 or 17 patients who have recovered from acute viral hepatitis. When such T cells were irradiated before coculture, the suppressor function was selectively eliminated, but the helper T-cell function remained unchanged. In serial studies, normalization of the excess suppressor function of T cells was observed when the liver function of an acute viral hepatitis patient returned to the normal range. Except for chronic active liver disease, in which the suppressor activity of T cells was substantially reduced in 50% of the patients studied. the studies indicated normal T-cell functions, both suppressor and helper, in other liver diseases such as chronic persistent hepatitis, inactive cirrhosis, and fatty liver disease. These data sugest that the host immunoregulatory mechanism might be important in recovering from acute viral hepatitis and in perpetuating hepatocyte injury in chronic active liver disease.

Adult↗
PubMed1980

Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS.

The serum thymic factor, 'facteur thymique serique' (FTS), was analysed in vitro for its ability to induce differentiation of normal human marrow T cell precursors into cells with T lymphocyte characteristics. FTS has been isolated, characterized, sequenced and synthesized. In the mouse, natural and synthetic FTS have similar activities in vitro in the rosette inhibition assay. Both substances influence a variety of T cell differentiation markers and functions in vivo. In this study, we found that synthetic FTS induced appearance of two T cell surface markers, HTLA phenotypes and the ability to form E rosettes, on a selective population of normal human marrow cells sedimenting in layers II or III of a Ficoll discontinuous density gradient. In addition, a population of lymphoid cells also found in layer III, which bears receptors for peanut agglutinin (PNA), was decreased in number following exposure to FTS. In the same gradient layer, cells which expressed terminal deoxyribonucleotidyl transferase (TdT) activity showed decreased activity after treatment with FTS. Functional activities characteristic of T lymphocytes were also enhanced in marrow cells of gradient layer III after preincubation with FTS. These T cell functions were demonstrated in marrow cells by their ability to respond and to stimulate allogeneic peripheral blood lymphocytes (PBL) in mixed lymphocyte reactions and by responses to phytomitogens, PHA, Con A and pokeweed. These changes were not observed in marrow cells of gradient layers I, IV and V or after incubation with an FTS analogue that lacked biological and antigenic activity in the mouse system.

Antigens, Surface↗
PubMed1979

Occurrence and significance of antibody to liver-specific membrane lipoprotein by double-antibody immunoprecipitation method in sera of patients with acute and chronic liver diseases.

A double-antibody immunoprecipitation method was developed for detecting antibody to liver-specific membrane lipoprotein (anti-LSP) in sera of patients with various liver diseases and primary nonhepatic autoimmune diseases. Liver-specific membrane lipoprotein prepared from normal rat livers was labeled with 125I (chloramine-T) and monospecific antibody raised in rabbits. Cross-reactivity and absorption studies demonstrated that the assay used was highly specific. The frequency and titer of anti-LSP were similar for HBsAg-positive and -negative patients with both acute and chronic liver diseases. Patients with chronic active hepatitis had the highest frequenzy (25 of 44 cases, 57%) when compared with those with chronic persistent hepatitis (5 of 23 cases, 22%) and nonalcoholic cirrhosis (8 of 21 cases, 38%). Of the anti-LSP positive cases, the mean titer in patients with chronic active hepatitis tended to be the highest. In patients recovered from acute viral hepatitis, anti-LSP was transiently positive (7 of 20 cases, 35%) in the acute phase. In those who progressed to chronic hepatitis, a late rise as well as an early rise occurred in 6 of 10 patients before the diagnosis was made. Two of 6 patients with primary biliary cirrhosis had anti-LSP, but none of 41 patients with other nonviral liver diseases and none of 60 patients with primary nonhepatic autoimmune diseases. These data indicate that an autoimmune reaction directed against LSP can be initiated during the acute phase of viral hepatitis and it may persist in chronic hepatitis in both HBsAg-positive and -negative cases.

Acute Disease↗
PubMed1978

Adenosine deaminase and purine nucleoside phosphorylase activities in lymphocytes from patients with lung cancer.

The activity of adenosine deaminase (EC 3.5.4.4.) was significantly lower in lymphocytes from patients with lung cancer than in those from healthy subjects, whereas the activity of purine nucleoside phosphorylase (EC 2.4.2.1.) was significantly higher in lymphocytes from the patients than in those from normal controls. When the one activity was plotted against the other, the plots for patients with lung cancer were all outside the frame formed by the lower and higher limits of the standard deviation of the mean of normal activities of the two enzymes. The ratio of adenosine deaminase activity to purine nucleoside phosphorylase activity was lower in patients with lung cancer than in controls. The possible effect of this ratio on the function of lymphocytes was briefly discussed. These enzyme activities were suggested to be useful measures of the immune responsiveness of patients with lung cancer.

Adenosine Deaminase↗