Biomedical subjects

K Yano

Publications and source records attributed to K Yano.

885 records · Page 50Linked to original sources

PubMedDate not supplied

A newly established mouse model of peritoneal dissemination in human pancreatic cancer.

Tissue from a Suit-2 cell line derived from human pancreatic cancer was transplanted into the normal pancreas of Balb/c nu/nu mice using a physiological fibrin adhesive kit (Beriplast P). A minced tissue specimen (2-5 x 10(2) mg) was transplanted into normal pancreas in each nude mouse, and immediately thereafter 10 microliters of type A solution and 10 microliters of type Bsolution of Beriplast P were administered simultaneously at the transplanted area. The tumor tissue promptly adhered to the normal pancreas. Ten days after the implantation of cancer tissue, neovascularization had also already formed around the cancer tissue. The transplantation ratio of cancer tissue in normal pancreas was 100% (20/20). The capsule around the cancer tissue had not clearly formed. Twenty-one days after transplantation, the cancer cells were observed to be disseminated and closely fixed to the mesentery. The dissemination ratio of this cell line in the mouse mesentery was 85% (17/20) at 21 days after transplantation. This nude mouse model might thus be useful for investigating the development of human pancreatic cancer.

Animals↗

PubMedDate not supplied

Hepatic venous injury; a case report of atriocaval shunt by a centrifugal pump.

Injury of hepatic vein confluence and retrohepatic vena cava is serious and often fatal. We report one such case that was successfully treated by the Biopump (Medtronic Bio-Medicus, Inc., Eden Prairie, Minn). A 21-year-old man was admitted due to a steering-wheel injury in a motor vehicle accident. CT scan showed extravasated contrast material around the right hepatic lobe, and a large low density area in the right hepatic lobe adjacent to the inferior vena cava, suggesting injury of the hepatic vein confluence or the retrohepatic vena cava. The patient underwent surgical treatment. Laceration of the liver was extended to the hepatic vein confluence. Right hepatic lobectomy and repair of the middle hepatic vein was successfully performed under atriocaval shunting by the Biopump.

Abdominal Injuries↗

PubMedDate not supplied

Mesenteric neurofibroma with von Recklinghausen's disease: a case report.

Mesenteric neurofibroma associated with von Recklinghausen's disease is rare. Herein, we present one such case. A 15-year-old mentally retarded Japanese boy presented with destruction of the right 2nd and 3rd ribs on a routine chest roentgenogram. Physical examination revealed a funnel chest and multiple cafe-au-lait spots, but no cutaneous nodules. Although the patient had no symptoms, a computed tomography (CT) and angiogram were performed. There were no definitive findings of malignancy in the tumors. However, since there were two risk factors for malignancy, specifically, a young age at the time of diagnosis and multiple tumors, and coupled with the size of the abdominal tumor which was large, the abdominal mesenteric tumor was removed. Pathological examination showed a neurofibroma with no evidence of malignancy.

Adolescent↗