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Biomedical subjects

K Yano

Publications and source records attributed to K Yano.

At least 721 records · Page 40Linked to original sources
PubMed1983

[Small dose of ARA-C in the treatment of an elderly patient with acute myeloblastic leukemia].

A 79 year old man with a history of myocardial infarction and cerebral infarction was admitted to our hospital in August, 1982. The hematological examination showed anemia and leukopenia (myeloblast 12%), and bone marrow aspiration confirmed the diagnosis of acute myeloblastic leukemia (FAB, M2). Because his general condition was poor, he was treated with small dose of Ara-C (10 mg/m2/12 hr, subcutaneous injections), obtaining complete remission. In cases of acute myeloblastic leukemia in elderly patients where other intensive treatments are contraindicated, it appears to be useful to employ a method of small dose of Ara-C therapy.

Aged↗
PubMed1983

[Clinical study on the effect of human lymphoblastoid interferon in multiple myeloma].

Ten patients with multiple myeloma were treated with human lymphoblastoid interferon (HLBI). The dosages used were 3 X 10(6) IU to 6 X 10(6) IU of HLBI intramuscularly daily. Out of eight evaluable patients, one partial remission and 3 minor response were observed. More than half patients experienced fever exceeding 38 degrees C and mild myelosuppression. Other toxic effects consisted of anorexia, malaise, liver dysfunction and skin rash. On the basis of our preliminary study, we conclude that HLBI is an effective agent against multiple myeloma.

Aged↗
PubMed1983

Pharmacokinetics of propylthiouracil in children and adolescents with Graves disease after a single oral dose.

Pharmacokinetics of propylthiouracil after a single oral dose were studied in six pediatric patients with Graves disease, with respect to influence of food intake. Propylthiouracil administration in the fasting state induced a rapid rise of plasma level reaching a peak of 30 to 60 min. Peak values ranged from 7.2 to 18 micrograms/ml with administered dose (100 to 280 mg/m2 BSA) and plasma half-life was 1.3 +/- 0.41 hr (mean +/- SD). Single compartment model with first order absorption showed excellent fit to the data obtained in the fasting state, but not in the fed state. Most individuals showed marked difference in the pattern of propylthiouracil concentration-time curves between the fasting and the fed state. Food intake prior to the drug ingestion was associated with lower and delayed peak and variable AUC values. These results indicate that propylthiouracil administration in the fasting state is more advisable for obtaining a consistent bioavailability.

Administration, Oral↗
PubMed1982

Glucose intolerance and nine-year mortality in Japanese men in Hawaii.

The relationship between glucose intolerance and nine-year mortality was examined in a cohort of approximately 8,000 men of Japanese ancestry living in Hawaii who were 45 to 68 years of age at baseline examination. Age-adjusted mortality for death from all causes, cardiovascular disease, coronary heart disease and causes other than cardiovascular disease and cancer were significantly higher in men with glucose intolerance, defined by either medication for diabetes or 1-hour post-load serum glucose levels above the 90th percentile cut-point (225 mg/dl) at baseline examination, than in normoglycemic men. Although many cardiovascular risk factors were found to be associated with glucose intolerance, both post-load serum glucose level and medication for diabetes remained significant as risk factors for overall, cardiovascular and coronary death in multivariate logistic analysis in which confounding effects of age, blood pressure, serum cholesterol, body mass index and other important risk factors were taken into account.

Age Factors↗
PubMed1982

Comparison of mutagenicity and chemical properties of N-methyl-N'alkyl-N-nitrosoureas.

The mutagenic activities of 11 N-methyl-N'-alkyl-N-nitrosoureas were tested on Salmonella typhimurium TA1535 and compared with chemical properties (alkylating activity and decomposition rate). In their relative mutagenicities the N-nitrosoureas that had a cyclic N'-alkyl groups showed far more mutagenic activity than those having a chain N;-alkyl group. M(1-A) NU and M(2-A)NU, which had the most bulky N'-alkyl group in this series, exhibited lethal effects at high concentrations. The mutagenicity showed a small positive correlation with decomposition rates but not with alkylating activities on 4-(p-nitrobenzyl)pyridine. The highest mutagenicity in this series was observed in N-methyl-N'cyclobutyl-N-nitrosourea. These results suggest that, in this series of N-methyl-N'-alkyl-N-nitrosoureas, structural differences in the N'-alkyl groups had great significance in mutagenicity.

Drug Stability↗