Biomedical subjects

K Y Pan

Publications and source records attributed to K Y Pan.

5 recordsLinked to original sources

PubMed2001

Severe reversible bone marrow suppression induced by Selaginella doederleinii.

CASE REPORT: We report a 52-year-old female patient with cholangiocarcinoma who developed severe bone marrow suppression after taking Selaginella doederleinii as an alternative anticancer treatment. She developed severe pancytopenia with initial presentations of skin ecchymosis, itching, and gum bleeding 2 weeks after taking Selaginella doederleinii daily. Bone marrow smear and biopsy showed severe hypocellularity with no malignant cell infiltration. Approximately 1 week after stopping Selaginella doederleinii, her hemogram returned to previous levels. Selaginella doederleinii, a popular anticancer herb, may contain an as yet unidentified substance that contributes to reversible bone marrow suppression.

Antineoplastic Agents, Phytogenic↗

PubMed1996

Polymorphism of IgE gene in chronic urticaria.

Our aim was to determine whether heterogeneity of the IgE (C epsilon) gene could be demonstrated in patients with chronic urticaria (CU). We performed Southern blots on DNA extracted from peripheral blood leucocytes of 20 patients with CU and 20 normal controls. Using a human C epsilon gene probe containing four exons of the constant segment of the IgE heavy chain, we showed the presence of a restriction fragment length polymorphism of the C epsilon gene segment in four of 20 patients with CU, but in none of 20 normal subjects. Family studies of two propositi revealed the presence of this C epsilon gene polymorphism in other family members. Our data show that a proportion of patients with CU have a polymorphism of the constant segment of the C epsilon gene. Further studies of this polymorphic gene fragment indicated that it was derived from duplication of the 3rd and 4th exons of functional C epsilon gene and was very likely to be located close to this gene. It raises the possibility that polymorphism of the functional C epsilon gene may affect expression of this gene. This could possibly lead to dysfunctional IgE-receptor interaction with consequent alteration in mediator release.

Adult↗

PubMed1994

The saturated response of vertebrate rods and its relation to cGMP metabolism.

Strong light flashes saturate the response of a rod, and increasing flash intensities prolong the period of saturation. We have found that the period of saturation lengthens from base to tip of the outer segment and we have shown that free cGMP is replenished locally to terminate saturation and not in the G-cyclase rich axonemal region near the inner segment which contains the cell mitochondria. Our results also show that each section of outer segment acts as an independent module in this phase of transduction.

Adaptation, Physiological↗

PubMed1994

[The mosquitocidal efficacy of microcapsules of alpha-cypermethrin against Anopheles sinensis].

The efficacy of spraying of alpha-cypermethrin microcapsule for the control of Anopheles sinensis was investigated when alpha-cypermethrin microcapsule was sprayed at 0.5 g/m2, the KT50 was 7.9 min and a 100% of 24 hours' mortality of An. sinensis, the efficacy being similar to that of the emulsion. 180 days after spray, the KT50 was 28.2 min, the 24 hours' mortality was 85.7%, the residual efficacy was 3 times over that of the emulsion. In the mimic field experiment, similar results were obtained. In the field trial, the residual efficacy of the alpha-cypermethrin microcapsule was 5.9 times that of the emulsion. Alpha-cypermethrin microcapsules is recommended as a good formulation of mosquitocide for mosquito control, considering its mosquitocidal efficacy and residual efficacy.

Animals↗

PubMed1990

Ventricular tachycardia and fibrillation detection by a sequential hypothesis testing algorithm.

An algorithm for detecting ventricular fibrillation (VF) and ventricular tachycardia (VT) by the method of sequential hypothesis testing is presented. The algorithm first generates a binary sequence by comparing the signal to a threshold. The probability distribution of the time intervals of the binary sequence is obtained, and Wald's sequential hypothesis testing procedure is next employed to discriminate the arrhythmias. Sequential hypothesis testing of 85 cases resulted in identification of 1) 97.64% VF and 97.65% VT episodes after 5 s, and 2) 100% identification of both VF and VT after 7 s. The desired false positive and false negative error probabilities can be preprogrammed into the algorithm. An important feature of the sequential method is that extra time for detection can be traded off for improved accuracy, and vice versa.

Algorithms↗