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Biomedical subjects

K Wulff

Publications and source records attributed to K Wulff.

At least 91 records · Page 5Linked to original sources
PubMed1980

A comparison of cognitive development in normal and psychotic children in the first two years of life from home movies.

Through the use of an unusual data base--home movies made by parents of the infancies and early childhood of their children who later developed a form of childhood psychosis and a control group of equal number who developed normally--the investigators studied the intellectual development of these children. Behaviors indexing Piaget's sensorimotor stages were recorded for both the index and control groups. The findings show several differences between index and control groups. Further, three aberrant cognitive patterns appeared in the sensorimotor behaviors of the subsequently psychotic children. These findings are discussed in relation to specific diagnosis and case history information.

Autistic Disorder↗
PubMed1980

Hydralazine in arterial hypertension. Randomized double-blind comparison of conventional/Slow-Release formulation and of b.i.d./q.i.d. dosage regimens.

Blood pressure (BP) control and tolerability of three two-week dosage regimens of hydralazine--conventional hydralazine q.i.d., conventional hydralazine b.i.d. and slow-release hydralazine b.i.d--were compared in a double-blind, randomized, cross-over trial in 20 out-patients with arterial hypertension controlled with hydralazine in combination with other antihypertensive drugs. The efficacy of the treatments was assessed during the last two days of each treatment period by determination of BP and pulse rate every hour between 8 a.m. and 6 p.m. No statistically significant differences in BP and pulse rate were found between the three treatment regimens, either in the variation during the day or in the mean value for the day. There was a tendency to lowest BPs on conventional hydralizine q.i.d. and to highest on conventional hydralazine b.i.d. Mean differences in supine BP between conventional hydralazine b.i.d. and slow-release hydralazine b.i.d. were 3.2 systolic and 0.5 mmHg diastolic. In this short-term study, mean values with 95% confidence limits indicate that conventional hydralazine in a q.i.d. dosage can be replaced by the same preparation or slow-release formulation in a b.i.d. dosage. Acetylator phenotype was determined and had no significant influence on the results, although there was a tendency to more widespread variability in systolic pressure and to a lower pulse rate in fast acetylators. Unwanted effects were few and did not differ obviously between the treatments. Whether the frequency of late toxicity of hydralazine is lower with slow-release formulation remains to be evaluated in long-term studies.

Adult↗
PubMed1979

Regional blood flow in normovolaemic and hypovolaemic haemodilution. An experimental study.

The effects on the circulation of limited normovolaemic haemodilution with dextran 70 and subsequent haemorrhage to a mean arterial pressure of 60 mm Hg were studied with isotope-labelled microspheres in the dog. Following haemodilution, cardiac output, stroke volume and systemic oxygen transport increased. The distribution of oxygen to the heart, liver (hepatic artery), spleen and carcass (mainly muscle, skeleton and skin) was increased, while a decrease in oxygen supply to the brain was found. Following haemodilution and haemorrhage, cardiac output, systemic oxygen transport and mixed venous oxygen tension decreased. Blood flow was redistributed to maintain the cerebral, renal, hepatic arterial and coronary circulations, mainly at the expense of blood flow to the carcass and through systemic arterio-venous shunts. Thus, limited normovolaemic haemodilution does not affect the normal circulatory response to moderate haemorrhagic hypotension.

Animals↗
PubMed1979

Regional lung function following hip arthroplasty and preoperative normovolemic hemodilution.

The effect of preoperative normovolemic hemodilution with dextran 70 as dilutional agent on postoperative regional lung function was evaluated in patients undergoing hip arthroplasty in the lateral decubitus position. The major part of the surgical blood loss of these patients was replaced with the received autologous blood. The results obtained were compared to changes in a group of patients in whom the operative bleeding was replaced with bank blood. Regional lung function, as studied with Xe133 radiospirometry, is not negatively influenced by the hemodilution technique. In both groups a reduction in perfusion, ventilation and volume of ventilated alveoli was revealed postoperatively in the lung that was dependent during surgery, probably caused by impaired ventilation of this lung and peroperatively induced microembolism. A more rapid normalization was found in the preoperatively hemodiluted patients. The reduced volume of bank blood transfused to these patients and/or a protective effect of the preoperatively infused dextran on the microembolism evoked by the surgical trauma might explain this difference between the groups studied.

Aged↗
PubMed1977

Preoperative normovolemic hemodilution in total hip arthroplasty. A clinical study.

Pre-operative normovolemic hemodilution was used in 20 patients undergoing total hip replacement. The hematocrit was lowered to 25-30% immediately before operation. 23 patients, in whom operative blood loss was replaced with bank blood, served as a control group. In the hemodilution group the amount of homologous blood transfusions was reduced with 50% compared to the control group. There was no significant difference in clinical complications between the two groups. The technique is simple and the increase in anaesthesia and operation time only about 20 min.

Adult↗
PubMed1976

Renal revascularization after splenic artery implantation into the kidney of dogs. Studies on renal function and blood flow.

Renal vascularization by splenic artery implantation into the kidney was studied in 11 dogs. Renal function and blood flow were evaluated after creation of stenosis of the ipsilateral renal artery. It was concluded that the method can be used to revascularize an ischemic kidney resulting in a sufficient renal blood flow with an adequate distribution of blood and maintenance of a reasonably good renal function after contralateral nephrectomy and division of the ipsilateral renal artery.

Animals↗
PubMed1976

Myocardiopathy in Duchenne progressive muscular dystrophy.

In a retrospective study of hospital and autopsy records of 19 male subjects with the Duchenne type of progressive muscular dystrophy the incidence of cardiac involvement of the heart almost invariably develop heart failure; an early sign may be persistent tachycardia and, possibly, electrocardiographic changes, in case of which institution of digitalis treatment should be considered. Cardiac and pulmonary complications were equally frequent causes of death (42%) but, death from cardiac complication occurred only patients with Duchenne progressive muscular dystrophy very often develop cardiac complications, and when relating the available information on treatment to the autopsy findings it should be stressed that early and intensive therapy of the cardiac symptoms is of the greatest importance to the patient.

Adolescent↗
PubMed1976

A percutaneous intra-arterial technique for producing renal artery stenosis.

A technique for creating an intra-arterial renal artery stenosis in the dog by a percutaneous approach is described. The effect of such a stenosis is evaluated with angiography, renal blood flow measurements, arterial blood pressure determinations and kidney histology. It is concluded that the method is applicable in studies on renal artery stenosis with the advantage of producing a progressive stenosis without any exploration of the kidney.

Animals↗