Is there a calcium-caused defect of oxidative phosphorylation in cardiomyopathic hamster hearts?
Mitochondria from cardiomyopathic hamster hearts have elevated calcium levels, which may cause a defect of oxidative phosphorylation in a small fraction of them. Using a combination of dual labeling density-gradient centrifugation, it was not possible to isolate such an abnormal fraction. However, cardiomyopathic mitochondria are more susceptible to damage by calcium in vitro, suggesting that an abnormal fraction does exist nevertheless.
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