Search PubMed⌕ Search

Biomedical subjects

K Wiśniewski

Publications and source records attributed to K Wiśniewski.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Effects of angiotensin II on the acquisition of conditioned avoidance response in alcohol-dependent rats.

The effect of angiotensin II (ANG II), given in a single intraventricular dose (2 micrograms ivc), on the course of acquisition of a conditioned avoidance response was studied in rats pretreated with alcohol. Ethanol administered for 6 or 18 days did not affect the acquisition, while a prolonged administration (for 2 months) markedly depressed the ability to learn. This effect was not only reversed by ANG II, but the peptide significantly elevated the acquisition rate above the control value.

Angiotensin II↗
PubMedDate not supplied

Effect of angiotensin II on passive avoidance performance after bilateral lesion of the nucleus accumbens septi.

The experiments performed earlier in this Department indicated that facilitatory effect of angiotensin II (AII) on recall is connected with its influence on dopaminergic systems. In an attempt to evaluate the possible site of action of AII on the memory processes, bilateral lesion of the nucleus accumbens septi (NAS, a limbic structure which receives projection from A 10 dopaminergic neurons) was made before behavioral testing of the influence of icv injection of AII on recall in passive avoidance situation. Unexpectedly, bilateral lesion of the NAS improved the recall itself. In such a situation any facilitatory action of AII on recall in this test could not be shown.

Angiotensin II↗
PubMedDate not supplied

Interaction of fibrinopeptides A and B with dopaminergic receptors in central nervous system.

The effect of fibrinopeptides A and B (FAB) on the action of compounds affecting the dopaminergic receptors in central nervous system (CNS) of rats was investigated. These peptides given intraperitoneally (ip) or intraventricularly (ivc) exerted dose-dependent stimulatory effects on the CNS: Enhanced the apomorphine and amphetamine-induced stereotypies and reduced the catalepsy induced by haloperidol. FAB depressed the dopamine level, especially when given together with alpha-MT, and elevated the level of homovanillic acid in the striatum. The results suggest that the stimulatory effects of FAB depend on their interaction with dopaminergic receptors in the CNS.

Amphetamine↗
PubMedDate not supplied

The role of some prostaglandins in the interaction of fibrinogen degradation products (FDP) with central dopamine receptors of rats.

Indomethacin and fibrinogen degradation products (FDP) augmented amphetamine and apomorphine-induced stereotypies. In contrast, PGE1 and PGE2 decreased the stereotypies in rats, while PGF2 alpha enhanced amphetamine-induced stereotypy. Indomethacin given in combination with the peptides did not change their effect, whereas prostaglandins diminished the stimulatory effect of FDP on the amphetamine or apomorphine-induced stereotypy. Indomethacin and studied prostaglandins did not influence inhibitory action of FDP on haloperidol-induced catalepsy. It is concluded that prostaglandins do not play any essential role in the interaction of FDP with dopaminergic system in the CNS.

Amphetamine↗
PubMedDate not supplied

Some pharmacological and biochemical effects of fibrinopeptides A and B in the circulatory system of rats.

Human fibrinopeptides A and B (FAB) increased the arterial blood pressure, accelerated the heart rate and elevated permeability of capillaries, produced a vasodilatory effect, evoked positive chronotropic and inotropic action on the isolated heart and did not affect the coronary flow. They lowered the content of glycogen in the heart muscle. They did not affect the concentration of glucose and elevated the content of lactic acid and free fatty acids (FFA) in the blood. As FAB are present in large quantities in the blood during disseminated intravascular coagulation, they may play an essential role in pathology of the circulatory system of mammals.

Animals↗
PubMedDate not supplied

Studies on the role of catecholamines in the action of fibrinopeptides A and B in the circulatory system of rats.

Effects of fibrinopeptides A and B (FAB) in the rat circulation were examined after stimulation or inhibition of catecholamine system. FAB did not change the effects of noradrenaline and isoprenaline and increased the hypertensive action of dopamine. The effects of FAB on heart rate and blood pressure were absent in rats pretreated with propranolol and haloperidol respectively. Reserpine, alpha-methyl-p tyrosine and disulfiram diminished or abolished the effects of FAB. Apparently FAB can modify the function of adrenergic system in circulation either directly or indirectly.

Animals↗
PubMedDate not supplied

Participation of prostaglandins in the action of kinins on the central dopaminergic system in the rat. I. The action of kinins on the central dopaminergic system after pretreatment with indomethacin.

The effect of intraventricularly (ivc) administered bradykinin (BRS) and activation of kininogenic enzymes of the cerebral tissue by kallikrein on dopaminergic system was investigated in tests of amphetamine (AMPH) and apomorphine (APO)-induced stereotypy and haloperidol (HAL)-induced catalepsy in rats receiving an inhibitor of prostaglandin synthetase, indomethacin (IND). The cerebral content of dopamine (DA), noradrenaline (NA) and homovanillic acid (HVA) was determined after some dosage schedules. In rats pretreated with IND the action of AMPH was potentiated and modulated by kinins (depending on the dose). IND prolonged the duration of APO-induced stereotypy and antagonized the action of low dose (1 mu g) of BRS, but potentiated the action of high doses (2 and 4 mu g) of BRS. IND potentiated the action of BRS on catalepsy induced by a low dose of HAL (0.75 mg/kg) but abolished the action of BRS on the catalepsy produced by a high dose of HAL (1.25 mg/kg). The results of biochemical investigation do not explain in full the behavioral changes.

Animals↗