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Biomedical subjects

K Wetzel

Publications and source records attributed to K Wetzel.

25 records · Page 2Linked to original sources
PubMed1980

[Diagnosis and clinical course of extra-uterine gravidity. Catamnestic survey of patients of gynaecological hospital of Jena University (author's transl)].

Reported in this paper are aspects relating to diagnosis and clinical course of 308 cases of extra-uterine gravidity, with reference being made to the authors' own experience and to comparable information in literature. The cases reviewed accounted for 0.86 per cent of all deliveries in the period considered. Tubal gravidity was diagnosed of 98 per cent of the cases and ovarian gravidity in 1.9 per cent, that is six cases. Concomitance of intra-uterine gravidity was established in two cases. The average age of the patients was relatively high, 29 years. Unambiguous correlations were established between the above courses, on the one hand, and parity as previous abortions or abdominal surgery, on the other. Four in 24 pregnancies of women with IUD were tubal pregnancies. Typical menstruation history was recordable from less than 50 per cent of the above patients. Early detection of unruptured tubal gravidity improved along with introduction of laparoscopy. Efforts have always been made to preserve fertility, whenever surgical treatment has been applied. There were no deaths.

Abortion, Induced↗
PubMed1979

[Absorption of amino acids in patients after partial gastrectomy (B II) and truncal vagotomy with pyloroplasty or antrectomy (author's transl)].

After surgery for gastric or duodenal ulcer the resorption of amino acids is changed due to alteration of morphology and function of stomach, bile system, pancreas and small bowel. We used the stable isotope labelled amino acid 15N-glycine in patients after partial gastrectomy (B II), truncal vagotomy with pylorplasty as well as antrectomy and in healthy persons. It could be shown that in contrast to the control group the absorption of the amino acid in the surgical group took place more rapid and more intensive.

Amino Acids↗
PubMed1979

[The human utilization of orally administered 15N-glycine].

In 7 convalescent patients we studied utilisation of a single dose of 15N-labelled glycine. In intervals we estimated total-N, urea-N, NH3-N and their 15N-abundances (urine). The following results were obtained. The peak of ammonium-15N appeared 25 minutes earlier than the peak of urea-15 N. The cumulative elimination of total-15N amounted to 25% of uptake after 24 hours and to 34.4% after 6 days. 12 hours after application 53% of the total amount, excreted within 6 days, were already eliminated. 24 hours after administration 80% of total-15N was urea-15N and 2.8% NH3-15N. Further we found correlations between N-balance (N-application minus excretion) and elimination of 15N-urea: If N-balance got more negative, the amount of cumulative elimination, the portion of urea-15N to total-15N and the percentage of elimination after 12 hours related to 6 days were elevated. That means that in stress condition utilisation of glycine to urea is higher and accelerated. The model seems acceptable, to get information concerning metabolic situation in a simple way.

Administration, Oral↗
PubMedDate not supplied

Transduction of human MCP-3 by a parvoviral vector induces leukocyte infiltration and reduces growth of human cervical carcinoma cell xenografts.

BACKGROUND: The oncosuppressive properties of some autonomous parvoviruses such as H-1 virus, together with their low pathogenicity, make them attractive vectors for tumor-directed gene therapy. Indeed, it was recently shown that these viruses became endowed with an enhanced oncosuppressive activity after they had been engineered to deliver a recognized therapeutic transgene. This prompted us to use a parvoviral vector to analyse the antineoplastic capacity of MCP-3 (monocyte chemotactic protein-3), a CC chemokine which has a broad spectrum of target cells, and can thus be considered to be a promising candidate for cancer treatment. METHODS: We explored the use of a parvovirus H-1-based vector encoding human MCP-3 for its antitumor potential on human cervical carcinoma cells. HeLa cells were infected in vitro with the recombinant virus hH1/MCP-3 at a low multiplicity [1 replication unit (RU)/cell] and we investigated the effect of parvovirus-mediated MCP-3 transduction on tumor formation and growth upon implantation of HeLa cells in nude mice. RESULTS: Infection of HeLa cells with hH1/MCP-3 led to secretion of high levels of MCP-3 and to significant retardation of tumor growth in recipient mice, as compared with HeLa cells that were either buffer-treated or infected with a MCP-3-free vector. Tumors from hH1/MCP-3-infected HeLa cells were heavily infiltrated with activated macrophages and showed increased numbers of dendritic cells. In addition, activated natural killer (NK) cells were also recruited into MCP-3-transduced tumors. CONCLUSION: These observations indicate that parvovirus H-1-transduced MCP-3 is able to exert a significant antitumor activity which is mediated, at least in part, through macrophages and NK cells, under conditions in which activated T cells are lacking.

Animals↗
PubMedDate not supplied

Nursing education and organizational commitment: degree versus diploma programs.

In the context of calls to change the educational qualifications for entry into the nursing profession, this study attempts to determine whether type of nursing education is associated with nurses' commitment to their employer hospitals. The analysis indicates that even when controlling for personal attributes, personal investments and work attitudes, type of nursing education is related to the level of organizational commitment expressed by nurses. Degree nurses are less committed than diploma nurses. Contrary to prevailing beliefs, the findings also reveal basic similarities between degree and diploma nurses on other measures of professional and work-related attitudes. From an organizational perspective, these similarities call into question the benefit of redefining educational entry standards.

Attitude of Health Personnel↗