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Biomedical subjects

K Warren

Publications and source records attributed to K Warren.

68 records · Page 4Linked to original sources
PubMed1975

Niridazole. II. A potent long-acting suppressant of cellular hypersensitivity.

Niridazole, a human anthelminthic drug, is shown to be a potent long-acting suppressor of delayed hypersensitivity. Much lower doses than used in the therapy of helminth infections suppressed granuloma formation around Schistosoma mansoni eggs for periods up to 32 days and inhibited delayed footpad swelling in mice previously sensitized with eggs. Marked prolongation of skin allograft survival in mice accross the H-2 area was produced. The drug is administered orally, has been used clinically on a massive scale, and appears to be relatively free of the cytotoxic effects of most immunosuppressive agents.

Animals↗
PubMedDate not supplied

A longitudinal study of job strain and ambulatory blood pressure: results from a three-year follow-up.

OBJECTIVE: This study was conducted to investigate the hypothesis that exposure to "job strain" is related to increased ambulatory blood pressure (ABP). METHOD: Participants were 195 men who wore an ABP monitor for 24 hours on two occasions 3 years apart. Job strain status, evaluated at each assessment, was used to identify four groups: those not having job strain at either assessment (N = 138), those having job strain at both times (N = 15), and two crossover groups. Regression analysis was used to examine the cross-sectional associations of ABP with job strain, controlling for other known risk factors. Repeated-measures analysis of variance was used to examine the association of ABP change with the category of job strain change. RESULTS: The cross-sectional analysis of the Time 2 data yielded almost identical, highly significant effects of job strain on ABP as was shown in our previously published Time 1 analysis. Those in high strain jobs at both times had systolic/diastolic ABPs at work and at home that were, on average, 11/7 mm Hg higher than those with no job strain at both times; the crossover groups had intermediate levels of ABP. The longitudinal analysis showed that those with a high strain job at Time 1, but not at Time 2, had a significant decrease in work and home ABP of approximately 5/3 mm Hg. CONCLUSIONS: The previously reported cross-sectional association between job strain and ABP was replicated at follow-up. The group repeatedly exposed to job strain had higher levels of ABP at Time 2 than either crossover group. Furthermore, change in job strain status partially predicted change in ABP. These results provide new evidence supporting the hypothesis that job strain is an occupational risk factor in the etiology of essential hypertension.

Adult↗
PubMedDate not supplied

Advance directives: a policy-capturing approach.

Policy capturing was used to provide insight into those factors that people consider important in the decision of whether to accept life-sustaining medical treatment. First, open-ended interviews with community-dwelling elderly persons (n = 30) were conducted to determine the factors they would consider when drafting an advance directive. College students (n = 53) then made judgments as to whether they would accept life-sustaining treatment for each of 100 hypothetical vignettes comprising a similar set of factors. Results revealed that 1) students made consistent judgments, 2) there was considerable variability in their mean judgments, 3) the most influential factors were mental and physical functioning, 4) mental and physical functioning had an interactive effect on judgments, and 5) subjective estimates of importance were significantly related to policy-capturing weights. This approach for studying the relationship of individuals' values to their acceptance of life-sustaining therapy may be useful in future studies of patient and surrogate decision making.

Advance Directives↗
PubMedDate not supplied

Job strain and health behaviors: results of a prospective study.

PURPOSE: To assess the association between job demands, job decision latitude, and job strain (defined by Karasek as a combination of high demands and low decision latitude) and cardiovascular disease-related health behaviors such as cigarette smoking, alcohol use, lack of exercise, and overweight. DESIGN: Cross-sectional and prospective. SETTING: Nine New York City public and private sector worksites. SUBJECTS: Two hundred eighty-five male employees, aged 30 to 60, in a wide variety of white-collar and blue-collar job titles. MEASURES: Medical examinations and surveys, which included demographic, health behavior, and job characteristics data. RESULTS: Prospectively, among 189 men, increase in job decision latitude over 3 years was associated with decrease in cigarette smoking, by analysis of covariance, controlling for age, race, education, marital status, and number of children at home (F (8, 180) = 4.37, p = .005). The largest increase in latitude occurred among the 13 men who quit smoking. However, change in job characteristics was not associated with change in overweight or alcohol use. Cross-sectional analyses did not produce consistent associations. CONCLUSIONS: The effectiveness of smoking cessation may be aided by modification of structural features of the work environment, such as job decision latitude. This study is limited by the small number of subjects who were engaged in high risk behaviors.

Adult↗
PubMedDate not supplied

An unusual case of ileocaecal tuberculosis in an 80-year-old Caucasian male.

An 80-year-old Caucasian male presented with a seven-week history of diarrhoea and weight loss. Distal duodenal biopsies showed partial villous atrophy but he failed to respond to a gluten-free diet. Subsequently he developed a right iliac fossa mass associated with radiological evidence of ileocaecal ulceration. Colonoscopic biopsies from the caecum showed non-caseating granulomata and Ziehl-Neelsen (ZN) staining and culture for acid-fast bacilli (AFB) were negative. Crohn's disease was diagnosed and he was started on steroids. Although he showed an initial response, his condition then deteriorated and he died after six weeks. ZN staining of tissue at postmortem showed AFBs. Although a rare diagnosis in the UK, a high index of suspicion should be maintained for ileocaecal TB in patients with appropriate clinical features, even if classical risk factors for TB are absent.

Aged↗
PubMedDate not supplied

Restorative treatment for patients with excessive vertical overlap.

The restoration of anterior teeth for patients with excessive vertical overlap is often complicated by a lack of space for restorative materials. This situation often occurs in patients with worn anterior teeth. Two methods of creating adequate space to permit satisfactory restoration are presented.

Dental Porcelain↗
PubMedDate not supplied

A review of principles and techniques for making interocclusal records for mounting working casts.

Obtaining an accurate interocclusal record for mounting working casts on an articulator is one of the most important procedures in determining the occlusal precision of restorations. This paper reviews the literature, describes some of the principles involved in making an interocclusal record, and illustrates practical techniques that may be used in a variety of clinical situations.

Humans↗