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Biomedical subjects

K Walker

Publications and source records attributed to K Walker.

At least 181 records · Page 10Linked to original sources
PubMed1981

Impact of prehospital cardiac algorithms on ventricular fibrillation survival rates.

To determine the value of algorithms in the field, a set of cardiac clinical algorithms was developed for and tested by the City of Philadelphia paramedics. A controlled test was carried out by revising the narrative standard operating procedure to reflect algorithm content and giving the algorithms, in pocket-size booklet form, to half the Fire Rescue platoons (43 men). Baseline data included paramedics' characteristics, arrhythmia recognition and management test scores, and data on the number of patients who were discharged alive from the hospital following successful treatment of ventricular fibrillation in the field. Platoons with and without the algorithms served identical areas of the city, did not differ in response times, and were treated similarly with regard to continuing education during the study period. Paramedics who received the algorithms were encouraged, but not required, to use them. Platoons using the algorithms experienced an increase in their ventricular fibrillation patient survival rates from 10.6% to 14.5%; those platoons not using the algorithms had a decrease in patient survival rates from 11.8% to 7.0% (P = 0.0732). There was no statistically significant difference in the paramedics' scores on arrhythmia recognition and management tests given before and after use of the algorithms. Only 39% of the paramedics used the algorithms during actual patient care, but 83% used them as a study guide or for reference between runs. The data suggest that algorithm use may minimize the rate of knowledge and skill decay.

Allied Health Personnel↗
PubMed1980

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Community Health Nursing↗
PubMed1980

Effects of glucose and insulin on the activation of lipoprotin lipase and on protein-synthesis in rat adipose tissue.

Glucose, and certain sugars that can readily be converted to glucose 6-phosphate, bring about an activation of adipose-tissue lipoprotein lipase when epididymal fat-bodies from starved rats are incubated in the presence of cycloheximide. Other substrates do not support the activation. If the tissue is preincubated in the presence of cycloheximide for longer than 2h, the ability of added glucose to activate the enzyme is lost. On the other hand, the addition of glucose still brings about an increase in lipoprotein lipase activity after preincubation in the absence of cycloheximide for as long as 4h. The magnitude of the increase in enzyme activity brought about by the addition of glucose is increased when protein synthesis is stimulated during the preincubation period by insulin. The results are interpreted in terms of the existence in adipose tissue of a proenzyme pool of lipoprotein lipase that is normally maintained by protein synthesis and that is converted to complete enzyme of higher specific activity by a process that specifically requires glucose.

Adipose Tissue↗
PubMed1978

The uptake of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline and its effect on 5-hydroxytryptamine uptake and release in blood platelets.

The uptake of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeOTHBC, 5-methoxytryptoline) by rabbit blood platelets was studied by using 3H-labelled compound. A high rate active uptake (Km 6.6 micron), which was inhibited by 5-hydroxytryptamine (5-HT) and cinnanserine, and a slow rate uptake, not inhibited by 5-HT were observed. The intracellular distribution of 3H-6-MeOTHBC in platelets clearly differed from that of 14C-5-HT. 6-MeOTHBC also competitively inhibited the high-rate active (but not the slow passive) uptake of 14C-5-HT, being more active than 5-HT itself. The spontaneous release of the newly taken-up 14C-5-HT from platelets was increased only with high concentrations of 6-MeOTHBC.

Animals↗
PubMed1978

Fetal erythropoiesis in steel mutant mice. III. Defect in differentiation from BFU-E to CFU-E during early development.

Erythroid progenitor cells in +/+ and Sl/Sld fetal livers manifested as burst-forming units-erythroid (BFU-E) and colony-forming units-erythroid (CFU-E) were assayed in vitro during early development. The proportion of BFU-E was higher as mutant than in normal fetal livers. On the other hand, the proportion of CFU-E was less in the mutant than in the normal. These results suggest that the defect in Sl/Sld fetal hepatic erythropoiesis is expressed at the steps of differentiation that effect the transition from BFU-E to CFU-E.

Animals↗
PubMed1978

The effect of prosthetic gallstones on total bile acid pool size in dogs.

A reduction in total bile acid pool size was noted in nine of ten dogs after the implantation of inert prosthetic gallstones. Sham cholecystotomy without implantation of a prosthesis also produced a small decrease in bile acid pool size but was significantly less than the decrease noted with prosthetic stones. Bile acid ratios--cholic acid, chenodeoxycholic acid and deoxycholic acid--did not change after implantation of prosthetic stones. These findings raise the possibility that the small total bile acid pool size noted in patients with cholesterol gallstones is a phenomenon secondary to the pathologic state of the gallbladder.

Animals↗
PubMed1978

Effect of wheat bran on serum lipoproteins and biliary lipids.

In this study nine patients with gallstones and nine healthy volunteers were given a high bran diet for 4 weeks. At the outset and at 4 weeks bile specimens were obtained for determination of biliary lipid values, size of the bile-acid pool and bile-acid ratios, and blood specimens were drawn to determine the serum concentration of triglycerides and of lipoprotein-bound cholesterol. Three patients with gallstones remained on the high bran diet for 6 months or more and samples were analysed again. The high bran diet produced a substantial decrease in biliary cholesterol values in patients with gallstones after 4 weeks, and a significant increase in the concentration of high density lipoprotein-cholesterol in the serum of patients who course was followed for 6 months or longer.

Bile↗
PubMed1975

Prolonged secretion of lithogenic bile after cholecystectomy.

Hepatic bile samples were obtained from 8 subjects 1 1/2 to 23 years after cholecystectomy for presumed cholesterol gallstones. The content of cholesterol, bile acids and lecithin was determined for each bile sample and compared to the values found in gallbladder bile in 15 control subjects undergoing cholecystectomy for pure and mixed cholesterol stones. Plot of the data on triangular coordinates and subsequent determination of lithogenic index showed that bile was supersaturated with cholesterol in both groups of patients. The cholesterol content of bile remained at supersaturated levels following cholecystectomy and showed no tendency to return toward normal levels with the passage of time.

Adult↗