Biomedical subjects

K Wakui

Publications and source records attributed to K Wakui.

At least 73 records · Page 4Linked to original sources

PubMed1976

Clinical significance of serum glutathione reductase in various clinical conditions, especially in liver diseases.

Serum glutathione reductase activity was measured in various conditions including acute hepatitis, chronic hepatitis, liver cirrhosis, malignant neoplastic diseases, and obstructive jaundice. A statistically significant elevation of the enzyme activity was found in all of these clinical conditions above normal value, especially in patients with acute hepatitis, some liver cancer, and malignant biliary obstruction. Comparison with other liver function tests showed the existence of statistically significant correlations of serum glutathione reductase with SGOT, SGPT and alkaline phosphatase in acute hepatitis, and with alkaline phosphatase in cirrhosis. In parenchymatous liver disease, serial determination was found to be important. High values in obstructive jaundice suggest the malignant obstruction.

Adult↗

PubMed1976

Chronic hepatitis: a follow-up study.

51 cases of chronic hepatitis were followed up by serial liver biopsies. 6 cases, all of which were of the active type, showed transition to liver cirrhosis within 5 to 10 months after the initial biopsy which had indicated chronic hepatitis. In 109 cases of liver cirrhosis, the antecedent acute hepatitis had been found within a relatively short period, usually 2 to 3 years before the establishment of the diagnosis of liver cirrhosis. Whether these cases which showed rapid transition to liver cirrhosis after acute hepatitis should be included in the group of chronic hepatitis or in another group remains to be settled.

Adolescent↗

PubMed1976

Significance of peritoneoscopic examination, direct cholangiography and cytological examination of aspirated bile in the diagnosis of biliary and pancreatic malignancies.

The roles played by peritoneoscopic examination, direct cholangiography and cytological examination of aspirated bile at the time of direct cholangiography were studied in 140 patients with various biliary and pancreatic diseases. Both peritoneoscopic and cholangiographic examinations were important in detecting the lesion, and cytological examination was effective in deciding the nature of the lesion. The detection rate of the cancer cells in aspirated bile depended upon the location of aspiration in relation to that of the lesion. The closer the distance the better was the detection rate. The combined use of these three diagnostic methods contributed to correct diagnosis.

Bile↗

PubMed1975

Glutathione reductase activity in serum and liver tissue of human and rat with hepatic damage.

Glutathione reductase activity of both serum and liver tissue homogenates was measured in normal controls and in cases of hepatic parenchymatous diseases, and the results were compared with those from animal experiments in which hepatic damage was produced by CCl4 injection. Glutathione reductase showed a different attitude from those of transaminases and alkaline phosphatases under these clinical and experimental conditions. Glutathione reductase activity increased in both serum and liver in patients with hepatic damage, and this increase occurred earlier than the changes in alkaline phosphatase activity.

Acute Disease↗

PubMed1975

Inhibition of serum alkaline phosphatase activity by phenylalanine and cholic acid.

Serum alkaline phosphatase activity was found to increase more markedly in patients with liver cirrhosis than in patients with peptic ulcer and this increase was found to be influenced by blood types. After testing several amino acids and bile acids, phenylalanine and cholic acid were chosen and their inhibitory effects upon serum alkaline phosphatase activity were studied in 66 patients with various liver diseases. It was found that the combination of both agents demonstrates different patterns of inhibition between the patients with liver cirrhosis and obstructive jaundice. This inhibitory effects were also variable among cases of different blood types. Basing upon the present observation, the possible source of the elevated alkaline phosphatase activity in liver cirrhosis was discussed.

Alkaline Phosphatase↗

PubMed1974