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Biomedical subjects

K Wagner

Publications and source records attributed to K Wagner.

At least 325 records · Page 18Linked to original sources
PubMed1979

[Anemias in infection, inflammation, tumors and liver, kidney and endocrine diseases].

Secondary anemias due to infections, malignancies, endocrinopathies, hepatic and renal disorders, are discussed in terms of pathogenesis, diagnosis and treatment. Typical features for each type of secondary anemia are presented to enable a diagnosis by means of simple laboratory methods. Differential diagnosis is rather difficult due to complex mechanisms of pathogenesis. The differentiation of iron deficiency, lack of growth factors, and hemolysis is of utmost importance. Frequently too little diagnostic work up is contrasted by too much mostly unnecessary treatment. The significance of neuraminidases in infections needs further research.

Anemia↗
PubMed1978

[Enzymatic determination of xylitol and sorbitol (author's transl)].

An enzymatic endpoint determination of xylitol and sorbitol by the use of L-iditol dehydrogenase is described. Despite the use of pH 9 and the addition of semicarbazide, the reaction goes only 80% to completion. Therefore a standard value has to be used. The lower limit for measurement of concentrations in serum is around 0.1 mmol/l. The most favorable range is between 0.4 and 1.2 mmol/l with a coefficient of variation of below 4%. Sensitivity and precision is higher than with the kinetic method described earlier. Further simplification for the routine control of infusion therapy with polyols is suggested.

Humans↗
PubMed1977

Prostaglandin release from macrophages: an assay system for anti-inflammatory drugs in vitro.

It is the intention of this communication to present a simple and reliable in vitro system for the evaluation of anti-inflammatory drugs. The system described appears to combine the advantages of two established procedures, i.e. measurement of the inhibition of prostaglandin (PG) synthesis in vitro using microsomal enzyme preparations and the measurement of the inhibitory effects of drugs on PG synthesis in vivo avoiding major limitations. We propose to measure the effect of drugs on the PG release from mouse peritoneal macrophages in vitro. The influence of culture conditions, phagocytosis and drugs on the PG release from these cells is described. We found that antibody-coated erythrocytes are especially suitable triggers of PG release, and that the release can be inhibited by steroidal and non-steroidal anti-inflammatory drugs in concentrations resembling their effective doses in vivo.

Animals↗
PubMed1976

[Biokinetic behavior and metabolic effect of fructose in high dose continuous infusion in the rat].

The steady-state blood level of fructose during 24 hours intravenous infusion in response to different doses follows saturation kinetics. Even after toxic doses of 1.5 g/kg/h no depletion of liver adenine nucleotides can be observed after 24 hours. In the kidneys, however, ATP, ADP and total adenine nucleotides were decreased after a dose of 1.5 g/kg/h of fructose. The blood glucose increased continuously at infusion rates of 1.5 g/kg/h. Inorganic phosphate in the blood increased at doses of 1.0 and 1.5 g/kg/h. The weight of the kidneys increased, presumably through water uptake. Urinary secretion was drastically reduced at doses above 1.0 g/kg/h. An appreciable activity of ketohexokinase can be demonstrated in the kidneys.

Adenosine Diphosphate↗
PubMed1976

[Questioning of diabetic patients on their knowledge of nutrition and dietetics as well as on their smoking habits].

100 diabetics were asked questions referring to the knowledge of nutrition to smoking habits. Most of the diabetics controlled their body weight regularly and were convinced that overweight may be dangerous to health. Despite this knowledge, more than half of the patients were overweight and did not know their individual ideal weight. Between the quality of dietary consultation and dietary behaviour of the patients a similar discrepancy existed: More than half of the questioned persons - especially males - had to be regarded as dietary failures. Patients with relatively low educational level came off worse. Fortunately, most of the patients were non-smokers. However, the dietary consultation practised at the moment seemed to have had no influence on the number of smokers. Consequently, for the training of the patients the following results: More than ever, the patients must be incited to normalize their body weight and they must be positively motivated in this regard as well as with regard to nicotine abuse. Behaviour therapy would certainly be desirable. Moreover, the patients should have a dietary consultation at least every second year. A dietary filled in for the patient personally must serve as the basis for the observance of the diet. Persons in whom diabetes mellitus was diagnosticated should receive consultation more quickly than up to now. Moreover, it would be useful to free the diet from the odium of an annoying and unimportant supplementation to medicamentous diabetes therapy. The study showed that continuous self-control of the own educational work is indispensable to guarantee a high standard of therapeutic efforts.

Adult↗