Intervention in childbirth and neonatal responsiveness.
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Biomedical subjects
Publications and source records attributed to K Wade.
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An apparent outbreak of fume fever was identified among six workers in an electronics instrument testing laboratory during a routine thermal evaluation of conductivity on electrical cable. The employees experienced characteristic symptoms of fume fever. Three employees required hospitalization; they demonstrated fever, leukocytosis with a left shift, and significant arterial-alveolar oxygen gradients, all of which resolved over several hours. To prevent future occurrences, an attempt was made to delineate the etiologic agent by exactly reproducing the circumstances of the event and analyzing for the evolution of metal fumes or pyrolysis products of polymers. The pertinent findings included overall poor ventilation in the laboratory and the development of significant chloride air contamination during the test. This latter finding raises the possibility that a chloropolymer contaminant was the etiologic agent.
Diffusion of oxygen and carbon dioxide across the walls of noncapillary vessels in the microcirculation has been suggested by several studies. The formulation and steady-state solutions to a nine-compartment mathematical model of the microcirculation of skeletal muscle with transmural gas diffusion in all vessels are presented. The simultaneous transport of oxygen and carbon dioxide between arterioles, capillaries, and venules, and connective and muscle tissue at rest and exercise are described. Special attention is paid to the interactions of these gases in blood. This model predicts a longitudinal intravascular gradient in oxygen tension from large to small vessel with the tension at the precapillary vessels relatively insensitive to changes in the input tension. At rest, there is significant small arteriolar oxygen flux. However, during exercise, the precapillary transmural flux of oxygen is only a small fraction of the total metabolic demand. The model predicts large noncapillary fluxes of carbon dioxide, and also that tissue PCO2 is dependent on input tensions. The model also predicts that Bohr shifts due to either changes in input PCO2 or increased precapillary PCO2 due to increased metabolism may cause physiologically significant changes in precapillary PO2. Countercurrent shunting was predicted by the model to be significant only for carbon dioxide.
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OBJECTIVE: Many women consume the raspberry leaf herb during their pregnancies in the belief that it shortens labor and makes labor "easier." METHODOLOGY: Because of the paucity of research regarding this herb, particularly in relation to pregnancy and birth, the authors undertook a double-blind, randomized, placebo-controlled trial. The sample consisted of 192 low-risk, nulliparous women who birthed their babies between May 1999 and February 2000 at a large tertiary-level hospital in Sydney, Australia. The aim of the study was to identify the effect and safety of raspberry leaf tablets (2 x 1.2 g per day), consumed from 32 weeks' gestation until labor, on labor and birth outcomes. RESULTS: Raspberry leaf, consumed in tablet form, was found to cause no adverse effects for mother or baby, but contrary to popular belief, did not shorten the first stage of labor. The only clinically significant findings were a shortening of the second stage of labor (mean difference = 9.59 minutes) and a lower rate of forceps deliveries between the treatment group and the control group (19.3% vs. 30.4%). No significant relationship was found between tablet consumption and birth outcomes. CONCLUSION: The lack of significant differences between the groups on measures expected to demonstrate the effect of raspberry leaf ingestion during pregnancy on labor prompted consideration of the issue of effectiveness of dosage level. Suggestions for further research are offered.