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Biomedical subjects

K W Stephen

Publications and source records attributed to K W Stephen.

141 records · Page 8Linked to original sources
PubMed1971

Comparison of human serum, parotid and mixed saliva levels of phenoxymethylpenicillin, ampicillin, cloxacillin and cephalexin.

1. A study has been made of serum, mixed and parotid salivary levels attained in normal volunteers following oral dosage of 500 mg phenoxymethylpenicillin tablets, 500 mg crushed phenoxymethylpenicillin tablets in capsules, 500 mg ampicillin, 500 mg cloxacillin and 500 mg cephalexin.2. High mixed saliva levels were obtained with phenoxymethylpenicillin tablets and it is considered that these were due to rapid intra-oral dissolution of surface powder from friable tablets. No saliva levels were detected when tablets from the same batch were put into capsules.3. Low or no saliva levels were achieved with ampicillin, cloxacillin and cephalexin.4. The mode of action of antibiotics in oral infections is discussed.

Administration, Oral↗
PubMedDate not supplied

The prevalence of fissure sealants in Lanarkshire, Scotland. A 3-year study.

Fissure sealant presence was recorded at baseline and annually during a 3-year, double-blind clinical caries trial which involved 3005 children aged 12-13 years at outset. At baseline, initially, 2002 sealants were noted in 431 subjects (14.3%), a figure not dissimilar to that found for Scottish 12-year-olds in the UK National Survey completed in the same year. By the fourth examination, 400 (17.3%) children had 2209 surfaces sealed. After one year, 14%, and at 3 years, 26% of baseline sealants were missing. Overall, at the last examination, 25% of baseline unsealed surfaces were carious compared to 15% of those originally sealed (P less than 0.001), although for molars, the equivalent figures were 49% and 24% (P less than 0.001). Finally, analysis showed that at baseline, as few as 15% of sealants had been placed by general dental practitioners, and this low proportion was maintained throughout the study period. While sealant placement in the Scots' age group was low, nevertheless the prevalence recorded was greater, at least by a factor of three, than has been reported elsewhere in the UK.

Child↗
PubMedDate not supplied

[Caries, fluorosis and salt fluoridation in the city of Szeged].

Salt fluoridation is effective at inhibiting caries, but fluorosis prevalence data are different. The purpose was to undertake a blind caries and tooth mottling study of 14-yrs-olds from S. E. Hungary who did (Test) or did not (Control) live, until 1985, in a 350 pp F-/kg salt fluoridated area during their early years of life. In Szeged, blind clinical and anterior tooth-mottling, radiographic and photographic recording of 49 previously salt-fluoridated and 59 non-salt-fluoridated subjects were undertaken by one examiner. In Glasgow, four dental and two lay staff scored the projected 35 mm colour transparencies of each pupil's teeth (13-23), for tooth mottling. Mean DMFS scores were 9.18 (SD = 10.72) and 4.51 (SD = 6.4) for Test and Control users respectively (p < 0.01). Clinically three Test children had fluorosis of 10 teeth, with 8 teeth in two Controls. In a sole Test case was "fluorosis" photographic unanimity obtained, and non-unanimous "possible fluorosis" was recorded by two-four 'jurors' for only three other Test and two Control subjects. No evidence was found that significant fluorosis resulted in subjects exposed previously to 350 ppm F-/kg salt early in life, but no caries benefit was demonstrated after the 11.5-yr salt fluoridation gap. These data emphasize (a) the superiority of substained community-delivered fluoridation, and (b) the need to maintain constant fluoride delivery to tooth surfaces, and certainly well beyond 10 years of age.

Adolescent↗