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Biomedical subjects

K W Min

Publications and source records attributed to K W Min.

At least 73 records · Page 4Linked to original sources
PubMed1990

Hemangiopericytoma of the nasal cavity.

Hemangiopericytomas are unusual vascular tumours that rarely occur in the paranasal sinuses and nasal cavity. They are thought to arise from pericytes that surround capillaries, however, there is no proven etiology of these tumours. The diagnosis cannot be made based on gross morphologic characteristics nor on frozen section biopsy. Instead, the diagnosis is dependent on careful histologic examination and reticulum staining. The diagnosis can be confirmed by electron microscopy. The histologic picture is greatly varied from tumour to tumour and within a given tumour itself. The clinical course of hemangiopericytomas ranges from benign to malignant with possible distant metastases and cannot be reliably predicted by histologic criteria. Hemangiopericytomas of the nose and paranasal sinuses are thought to behave less aggressively than those occurring in other parts of the body. Lymph node metastasis is rare and elective neck dissection is not indicated. The accepted treatment of these tumours is wide surgical excision, however adequate surgical margins are usually difficult in the sinonasal region. As a result, hemangiopericytomas can exhibit a high recurrence rate. Therefore, it is mandatory that these patients be followed carefully for the remainder of their lives.

Adult↗
PubMed1990

Acute renal failure due to ciprofloxacin.

Acute renal failure developed in three patients within a few days of starting ciprofloxacin hydrochloride therapy. An allergic interstitial nephritis was suggested by fever and eosinophiluria in one patient and by erythema multiforme in another. A kidney biopsy specimen confirmed this diagnosis in one patient. Renal function improved shortly after withdrawal of the drug in all three patients. Literature survey revealed an additional three patients with a similar complication. Allergic manifestations, such as fever or rash, were a feature in most reported cases. In view of this potential complication, renal function should be closely monitored in patients receiving ciprofloxacin therapy, especially if other potentially nephrotoxic drugs are prescribed concomitantly.

Acute Kidney Injury↗
PubMed1988

Malignant renal rhabdoid tumour. Immunohistochemical and ultrastructural studies.

In an effort to establish their possible histogenesis, three cases of renal rhabdoid tumour and their metastases were studied both by a battery of polyclonal and monoclonal antibodies using the avidin-biotin-peroxidase complex technique and by electron microscopy. Vimentin was demonstrated in renal rhabdoid tumour in two cases and in all metastatic deposits. Cytokeratin (39, 43 and 50 kD) was not demonstrable in the three renal rhabdoid tumours, but was strongly positive in all metastatic lesions in one case. Epithelial membrane antigen was present in one renal rhabdoid tumour and in pulmonary metastases in two cases. Ultrastructural study showed epithelial differentiation in all tumours: basal lamina and convergent tight junctions were demonstrated; intracytoplasmic intermediate filaments were present in all primary and metastatic tumours. Rhabdoid tumours thus exhibited heterogeneous immunophenotypic expression suggesting that they are derived from mesenchymal cells which are capable of differentiating into epithelial cells.

Antibodies, Monoclonal↗
PubMed1988

Hepatic hemangioendothelioma of infancy associated with elevated alpha fetoprotein and catecholamine by-products.

Five cases of hepatic hemangioendothelioma (HH) were seen in infants ranging from 2 days to 5 months of age. The cases were studied by clinical chemistry, immunohistochemical staining, and electron microscopic techniques. Serum alpha-fetoprotein (AFP) levels were elevated in each of the four patients in whom levels were obtained. The highest elevation was noted in a 2-day-old infant with a diffuse, unresectable lesion involving the right lobe. Two patients who underwent complete resections of their solitary HH had normalization of their AFP levels. This study suggests that AFP levels in patients with HH are closely related to the patients' age, with the youngest patient having the highest levels of AFP. Catecholamine by-products (VMA and HVA) were elevated in one of four patients in whom levels were obtained, this infant was 3 months old at the time of presentation. She also had an elevated AFP level, a diffuse unresectable lesion involving the entire liver, multiple pulmonary nodules, and cutaneous hemangiomas. Immunohistochemical study failed to demonstrate the source of AFP or the catecholamine by-products in the tumor of this patient, suggesting that the source of catecholamine by-products could be stress-induced catecholamine secretion.

Antigens↗
PubMed1987

Postnatal evolution of the human pineal gland. An immunohistochemical study.

Pineal glands from 16 infants ranging from 38 weeks gestation to 3 years of age were fixed in buffered formalin; Paraffin sections were stained for neuron-specific enolase, glial fibrillary acidic protein, and S-100 protein (S-100) using the peroxidase-antiperoxidase method and hematoxylin and eosin, Masson-Fontana, and Bodian stains. The pineal glands of neonates consisted of cords of closely packed, dark, nucleated cells (type I) with intervening loosely arranged, large, clear cells (type II). The type I cells were frequently pigmented and occasionally exhibited rosette formation. They were positive for S-100 and negative for neuron-specific enolase. The type II cells were strongly positive for neuron-specific enolase and negative for melanin and S-100. The type I cells were the predominant cell type at birth; however, the number of type II cells gradually increased with age, and by the age of 1 year, only scattered S-100 positive cells, consistent with sustentacular cells, were found. The findings indicated that the human pineal glands undergo a remarkable morphologic and functional evolution as an endocrine organ in the postnatal life.

Cell Differentiation↗
PubMed1986

Juvenile xanthogranuloma. Ultrastructural and immunocytochemical studies.

Morphologic features of three cases of juvenile xanthogranuloma (JXG) were consistent with the current concept of a benign process, although the lesion in one case grew steadily to an extensively infiltrating large mass, which clinically suggested a malignant growth. Ultrastructurally, the lesion consisted of morphologically different developmental stages of histiocytes, probably reflecting different functional levels. An interesting finding was the presence of occasional subplasmalemmal linear densities between these cells. These densities were at times symmetrically opposed, forming desmosomelike junctional complexes. Immunohistochemical study for the presence of lysozyme, alpha 1-antitrypsin, and S100 protein by the avidin-biotin-peroxidase complex was performed in all three cases. All immunostains were negative except the positive lysozyme stain in two cases. The ultrastructural and cytochemical characteristics of histiocytes in JXG were similar to epithelioid cells in the lymph node, suggesting that JXG is a reactive lesion.

Desmosomes↗