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Biomedical subjects

K W Frey

Publications and source records attributed to K W Frey.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Scintigraphy and tomography in inflammations and non-malignant tumors in head and neck (author's transl)].

Scintigraphy is a non-invasive technically simple tool for diagnostic in the head and neck. Using nuclides with a short life time the irradiation of the skeleton is less than 1 rd. Scintigraphy in addition to X-ray examination is useful in diagnosis and surveillance of different osteoplastic tumors (like osteoma, osteoplastoma, cementoma, meningioma) and in systemic diseases of the bones (fibrotic dysplasia, Morbus Paget). Concerning inflammatory diseases osteomyelitis is the main indication for scintigraphy, but it is as well usefull in the diagnosis of complications of inflammatory diseases of the sinuses, like mucocelia or non resorbed antibiotics which provoked an inflammatory reaction of the mucosa. There is no indication for scintigraphy regarding its low specificity in common acute or chronic sinusitis.

Adult↗
PubMed1981

[Bone scintigraphy in the diagnosis and follow up care of malignant head and neck neoplasms].

In diagnosis and localisation of malignant tumors with destruction of the bone, scintigraphy has its special importance in diagnosis as an addition to X-ray tomography. When carcinoma are localized in the middle or dorsal part of the base of the skull scintigraphy may help to calculate the chance for an operation. The exact knowledge of the dimension of the tumor is a valuable help in radiotherapy. In primary diagnosis of destructions of the base of the skull scintigraphy might give an earlier information than X-ray. Malignant tumors of the ear however are sufficiently detected by means of X-rays alone. The main field of scintigraphy is the observation of irradiated and operated malignoma. We recommend 6 or 12 months controls in combination with a clinical observation and with tomographic controls. Scintigraphy became a most valuable tool in the search and diagnosis of metastases in primary malignoma of the mammae, the lungs or the kidneys. In case of metastases in the skull scintigraphy is most helpful to detect them often earlier than by means of X-rays.

Adult↗
PubMed1981

[X-ray tomography in fractures of the temporal bone and injuries of the ossicula (author's transl)].

Since a high percentage of cross-fractures of the temporal bone cannot be verified in standard projections, tomography is indicated under clinical aspects. With this technique even small fractures concerning the meatus acusticus internus, the labyrinth, and the proximal part of the canalis facialis can be diagnosed. Experimental data concerning longitudinal fractures with facial palsy show the course of the fracture but not the exact point of the lesion. Additional information will be given to verify luxations or displacement of the ossicula.

Adult↗
PubMed1980

[New developments in diagnosis and treatment of renovascular hypertension (author's transl)].

Catheter-dilatation (percutaneous Transluminal Angioplasty=PTA) of renal artery stenoses can be applied successfully and without major risk even in patients with high operative risks. Therefore, the indication for the diagnostic evaluation of renal artery stenosis should be expanded to all patients suspected to have renovascular hypertension. Excretory urography combined with angiotomography offers the possibility to visualize the renal arteries and to either detect or exclude arterial stenosis. In the first part results of this procedure are presented. The bolus injection have been carried out on 415 patients without any serious side-effects. Using angiotomography 49 renal artery stenoses, 1 aneurysm and 1 AV fistula could be detected. Catheter-angiograms, angiotomograms and conventional rapid sequence urograms were compared in 91 patients. For angiotomography a sensitivity for the presence of renal artery stenosis of 93% and a specifity for the absence of arterial stenosis of 99% can be attained. In the second part, the results of PTA of renal artery stenoses in 35 patients are described. PTA was technically successful in 29 patients (83%). Three clinically silent complications are reported. In a mean follow-up period of 8,2-months, hypertension was normalized in 13 (45%) and improved in 10 (34%) patients. Renal insufficiency could be normalized in 7 out of 11 patients. These results make PTA the method of choice in treating renovascular hypertension. Only if this method is not applicable or technically not feasible, is the alternative for treatment surgical revascularization or conservative antihypertensive therapy.

Adult↗
PubMed1980

Fracture healing under factor XIII medication.

Following application of factor XIII for 3 weeks bone healing was studied in Sprague-Dawley rats on the 20th postoperatively day qualitatively (radiographs, scintigraphy) and quantitatively (determination of callus thickness, of bone mineral content, and scintillation counting). No significant difference could be detected between animals treated with factor XIII and animals which served as controls. Therefore, a stimulating effect of factor XIII upon bone healing can not be expected in case of a normal factor XIII serum-level. The application of factor XIII is indicated only in high risk patients with a low factor XIII serum-level.

Animals↗
PubMed1980

Visualization of the renal arteries during excretory urography.

1. Intravenous excretory urography was modified and expanded in order to visualize the aorta and the renal arteries. 2. The new procedure consists of the rapid intravenous injection of contrast medium, determination of the circulation time between the injection site and abdominal aorta, tomography with a multileaf cassette with five films (angiotomography) and continuation of the investigation as with routine excretory urography. 3. In 343 patients a total of 739 single or multiple renal arteries were identified at least partially. Of these, 83% could be clearly outlined between the aorta and the first division. 4. In 71 hypertensive patients angiography and angiotomography were separately evaluated. With angiotomography all 165 single or multiple renal arteries seen with angiography were visualized at least partially, whereas a total of 149 (90%) of renal arteries could be completely outlined between the aorta and the first division of the renal arteries. 5. A sensitivity for the presence of renal artery stenosis of 92% and a specificity for the absence of artery stenosis of 99% can be calculated for angiotomography in the diagnosis of renal artery stenosis. 6. Thus this method permits the detection or exclusion of renal artery stenosis in almost three-quarters of patients with hypertension, without angiography.

Adult↗
PubMed1980

[The technique for demonstrating the renal arteries during an excretion urogram. Bolus technique--timing--simultaneous tomography (author's transl)].

The aorta and renal arteries, as far as their intrarenal branches, can be demonstrated in the course of an excretion urogram if the contrast medium (1 ml/kg body weight, maximum 60 ml) is injected at a flow rate of 10 to 15 ml/sec (Bolus technique). The intravenous bolus injection was carried out in 180 patients without any significant complications. In order to obtain the correct timing on a single film it is necessary to determine the circulation time from the arm vein to the abdominal aorta in each individual. The addition of 0.2 to 0.3 mCi 99mTc to the contrast medium makes it possible to determine the circulation time accurately. This varied from 9 to 22 seconds. By using tomography with 1 cm cuts and a 4.5 cm format, it was possible to show the left or right renal arteries from the aorta to their intrarenal branches in 82% patients. In 126 (70%) of the 180 patients, both renal arteries were demonstrated. The demonstration of renal arteries during the course of an excretion urogram represents an advance on the conventional technique. The indications are discussed.

Adolescent↗
PubMed1979

[Early and late results of 131I treatment of benign goitres in an endemic area in southern bavaria (author's transl)].

Following the application of 10 000 to 15 000 rd, to 471 patients with benign goitres, mechanical symptoms were relieved in 72 to 82% during a course of six follow-up examinations; the circumference of the neck was reduced by 1.2 to 1.6 cm., the scintigraphic area by 9 to 31% and maximal 131I uptake was reduced by 18 to 31%. Follow-up examinations at 6.4 and 5.5 years in 155 patients showed the best regression of neck circumference (2.2 to 2.6 cm.) and of the area of the scintigram (28 to 31%). 50% of the patients had had recurrences from previous goitre removals and 1 to 3% developed post-therapeutic hypothyroidism. There was no significant change in the level of the peripheral thyroid hormones following treatment, but 10 to 20% were within the hypothyroid range for the area of iodine deficiency.

Disease Reservoirs↗
PubMed1978

[Echographic or radiographic cholecystography? (author's transl)].

In a prospective echographic and radiographic investigation of 281 patients and in a retrospective evaluation of 86 operated patients, echography and radiography gave approximately equally accurate diagnoses. By using both methods no pathological finding will be overlooked. For reasons of radiation protection, echographic examinations should be carried out first. If the echographic results agree with the clinical findings the radiological cholecystography can be dispensed with. Radiological investigation should be carried out if the echographic findings are at variance with the clinical findings. Consequently echographic cholecystography certainly cannot replace radiography, but it does contribute in that radiographic examination can be used selectively.

Cholecystography↗
PubMed1976

[Incidence of goiter and tracheal constriction among outpatients of a Munich hospital (author's transl)].

With a goiter incidence of 55%, 6.5% of the 495 patients examined showed constriction of half or more of the trachea, most frequently in the 10% of larger goiters in stages II and III. But also in the 45% of the stage I goiters occurring in the Munich ambulant patients, distinct tracheal constriction is already found, and in stage lb 9% of the stenoses involved half of the lumen. Because of the high goiter rate and the often already considerable tracheal stenoses even in the smaller goiters, the earliest possible diagnosis and treatment of small goiters with iodized salt or thyroid hormones should follow as a consequence, after exclusion of autonomic adenomata, thyrotoxicosis, cold nodules and malignant struma. The prophylaxis of struma with fully iodized salt is referred to.

Adult↗