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Biomedical subjects

K W Cross

Publications and source records attributed to K W Cross.

At least 73 records · Page 4Linked to original sources
PubMed1970

Respiratory stimulants in treatment of perinatal asphyxia.

The effects of two analeptic drugs-taloximine and ethamivan-have been studied in asphyxiated fetal and newborn rabbits. In primary apnoea ethamivan reduced the time before the onset of gasping, while during gasping taloximine increased the gasp rate. In secondary apnoea neither drug initiated respiration, though most animals could be resuscitated by using intermittent positive pressure respiration. From these results it is suggested that analeptic drugs have no place in obstetric or neonatal departments.

Animals↗
PubMed1969

The oxygen uptake and pulmonary blood flow during resuscitation from asphyxia in foetal and adult sheep.

1. The foetuses of twenty-seven Welsh ewes and eight Clun Forest ewes were delivered by Caesarian section at an approximate gestational age of 140 days, maintaining the umbilical circulation. They were asphyxiated by clamping the umbilical cord, and resuscitated with IPPV. Oxygen consumption, heart rate, and blood pressures were recorded, and in one series of eight, blood flow through the left lung was recorded whilst IPPV was applied to this lung only.2. The hypothesis that oxygen consumption is abnormally low during resuscitation of the new-born from extreme asphyxia because of limited blood flow, was supported.3. Adult ewes were also asphyxiated and in a series of eight a quite different pattern of behaviour was observed, due to very rapid and complete recovery of the circulation.4. Observations on the pulmonary vascular resistance suggest that complete vasomotor paralysis occurs during extreme asphyxia, so that resistance falls to a near-minimum level for unexpanded lung. Expansion of the lung produced a large fall in resistance which appeared to be due to the introduction of gas into the alveolar spaces, lessening the resistance to flow of the capillaries.

Animals↗
PubMed1968

Changing use of hospital beds by the elderly.

Recent changes in the age structure of the mental hospital population in the Birmingham Region are first examined. The proportion of patients aged 65 and over of the total in residence has steadily increased and at the end of 1967 was 43%, and more than half the female patients are now in this age group.Admissions of elderly persons to both psychiatric and general hospitals have increased, and these hospitals have responded to the increased demand on their services by increasing bed-turnover rates. During 1967 on average one-fifth of all patients occupying beds for acute cases (excluding maternity) were 65 years of age or over.In the geriatric hospital service, on the other hand, accommodation per head of the population decreased between 1961 and 1967, as did the total annual number of admissions and the rate of turnover. This suggests that the geriatric service is overstretched and that it is under-organized, understaffed, or undercapitalized-possibly all three. The enforced expedient of admitting "excess" elderly patients to mental hospitals does not recommend itself.

Age Factors↗