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Biomedical subjects

K Vogt

Publications and source records attributed to K Vogt.

At least 73 records · Page 4Linked to original sources
PubMed1985

The contribution of different colour receptors to a motor output in the fly.

A light flash given to the eye of Calliphora leads to a movement of the legs (light induced leg reflex) which most likely normally initiates flight of the animal. This reflex has a short latency (12 to 30 ms, depending upon light intensity) and is quite reproducible without habituation. The spectral sensitivity of the reflex shows that receptors R1-6 most likely govern the input to the reflex in dark adaptation, a contribution of receptors R7 can be demonstrated with selective chromatic adaptation.

Animals↗
PubMed1985

[Dose-dependent effect of amrinone on hemodynamics, myocardial circulation and myocardial energy requirement. An experimental study].

This study was designed to assess the dose-dependent effects of amrinone (1, 2 and 4 mg/kg i.v.) on hemodynamics, myocardial blood flow and myocardial oxygen consumption in anesthetised closed chest dogs (n = 8). Heart rate (HR), cardiac output, mean aortic pressure (MAP), left ventricular end-diastolic pressure (LVEDP), maximum dp/dt (dp/dtmax), myocardial blood flow (MBF) and aorto-coronary sinus oxygen difference (AVDO2 cor) were measured. Cardiac index (CI), stroke volume index (SVI), ejection fraction (EF), total peripheral resistance (TPR), coronary vascular resistance (CVR) and myocardial oxygen consumption (MVO2) were calculated from standard formulas. Amrinone improved myocardial pump function by a direct positive inotropic effect on the myocardium. EF and SVI increased to a maximal degree with 1 mg/kg amrinone (28% resp. 30%). dp/dtmax increased dose dependent (46, 64, 71%). Following a systemic vasodilation due to amrinone, left ventricular filling pressure and TPR decreased significantly. With 1 and 2 mg/kg amrinone MAP remained unchanged. 4 mg/kg produced a distinct fall in MAP accompanied by an increase in HR. The improvement in myocardial contractility did not cause a comparable increase of myocardial oxygen consumption. Due to an unloading of the heart 1 and 2 mg/kg amrinone induced no significant and prolonged augmentation of the myocardial oxygen demand. In the coronary circulation a non energy dependent vasodilation occurred followed by a marked decrease of AVDO2 cor (10, 18, 28%).

Aminopyridines↗
PubMed1983

[Hyperphosphatemia and tetany following phosphate enema].

Two patients with renal failure presented postoperatively with marked hyperphosphatemia and symptomatic hypocalcemia. This phosphate intoxication was due to a commonly used phosphate-containing enema. An increase in phosphatemia was also seen in two other patients prospectively followed after receiving the same product. The phosphate increase depends upon the retention duration of the enema. The use of phosphate-containing enemas in patients with renal failure is not entirely risk-free.

Enema↗
PubMed1983

Plant seeds contain several thioredoxins of regular size.

Thioredoxin systems composed of several thioredoxin isoproteins and a NADPH: thioredoxin reductase are contained in the albumin-globulin fraction of wheat and soy-bean seed proteins. Two wheat thioredoxins I and II were separated on CM-cellulose whereas soy-bean extracts could be resolved into three thioredoxins I, II, and III on DEAE-cellulose. These proteins were purified to apparent homogeneity and were shown by sodium dodecylsulfate/polyacrylamide gel electrophoresis to possess the molecular weight Mr identical to 12000 typical of the single bacterial and animal thioredoxin. In contrast, gel filtration runs may yield erroneous estimates of thioredoxin molecular weights. The seed thioredoxins can serve as ribonucleotide reductase (Escherichia coli) substrates. They stimulate spinach NADP: malate dehydrogenase but are inactive towards chloroplast fructose-bisphosphatase. These results demonstrate that the number of thioredoxins in nongreen plant tissues approaches that of leaves; additional explanations must therefore be sought for the multiple thioredoxin profiles of plants besides diversification for light-dependent and light-independent functions.

Bacterial Proteins↗
PubMed1979

[Resistometry-improvement of the hydrodynamic function test of sinus frontalis duct system (author's transl)].

The biophysical and technical base as well as clinical applications of a new functional diagnostic system of sinus frontalis disorders are described. The system consists of a ventilation test and the so called "resistometry". The principle of the resistometry is the generation of a fluid flow in the frontal sinus duct system by a pressure regulated injector, the measurement and registration of flow and pressure and the calculation of the hydrodynamic resistance of the duct system. The resistance is determined in "Resistance Units" (RU). The possibilities of the proposed diagnostic system in differential diagnosis are shown in 156 cases. Apart from the quantitative assessment of the classical inflammations of the frontal sinus the functional diseases of the duct system may be discriminated with certainity.

Diagnosis, Differential↗
PubMed1979

[Anatomical variations of frontal sinus duct system. results of radioresistometric examinations (author's transl)].

With the aid of the authors x-ray examination of radioresistometry the multiple variations of sinus frontalis drainage ways are classified in accordance with the nomenclature of Prott. A simple connection between the frontal sinus and the nose has been found in only one third of cases, in all other cases the drainage ways are divided during the passage of the ethmoideal cell system.

Drainage↗
PubMed1978

[Secretion pressure of human submandibular gland (author's transl)].

The secretion pressure as well as the resistance of Glandula submandibularis towards retrograde instillation of water are determined electromanometrically. The results are compared with such measurements carried out by the same method in the parotid gland. The pressure behaviour of the submandibular gland corresponds with some quantitative differences to the behaviour of the parotid gland. The differences show the generally lower secretion power of submandibular gland. However there are no differences in the resistance against a retrograde instillation of water between submandibular and parotid gland. The connections of the observed and calculated parameters and clinical patterns are discussed.

Age Factors↗
PubMed1978

Control of hormone treatment in animals and residues in meat--regulatory aspects and approaches in methodology.

Although the benefit of using anabolic hormones for fattening purposes under specific situations in animal husbandry (for instance, veal production) has been acknowledged in European countries, the regulatory consequences were quite different from those in the United States. With the exception of the United Kingdom, there were no approvals to use estrogens for other than distinct veterinary purposes. Hence the methodological approaches were rather to control the illegal treatments and imports. One measure is the uterus weight bioassay. Furthermore morphological parameters (prostate test) and estrogen determinations by thin layer chromatography in urine (also from the bladder) were proposed for detection of treated animals. Radioimmunoassays are in development and considered sensitive enough for residue studies in carcasses, perhaps applicable in combination with high pressure liquid chromatography. The re-evaluation of the regulatory situation is in progress in France and Germany and under consideration in the United Kingdom. Guidelines may be the recommendations of the FAO/WHO Symposium 1975 in Rome on anabolic agents in animal production indicating the variety of risks due to different compounds in question and preference to those with low oral activity and defined bio-degradation.

Biological Assay↗
PubMed1978

Lymphokines. VI. Factors in human and other heterologous sera inhibiting the migration of guinea pig macrophages.

Different heterologous sera including human, rabbit, bovine and fetal calf serum (FCS) showed a strong inhibiting effect on the migration of guinea pig peritoneal macrophages (GPPM), compared to the migration of GPPM in homologous guinea pig serum. The inhibiting effect of these sera on the migration of horse monocytes on the other hand was much less marked. Fractionation of human and rabbit serum showed the 4 S fraction to be most inhibitory on GPPM migration. The migration inhibiting effect of heterologous sera on GPPM was prevented by addition of homologous (GP) serum, by absorption of the sera by various guinea pig cells, by heating at 56 degrees and by addition of alpha-L-fucose. Human sera were found to be strongly cytotoxic for 51Cr-labelled guinea pig erythrocytes and lymphocytes, but not for horse lymphocytes. Upon absorption with guinea pig erythrocytes, lymphocytes and kidney cells, the cytotoxicity of the human sera was strongly reduced. Accordingly, the role of heterophilic antibodies and/or of heat-labile MIF-like factors in heterologous sera has to be considered in al macrophage migration experiments where heterologous sera are being used. These factors may differ from the heat-stable MIF activity generated upon antigen- or mitogen-induced stimulation of cultured lymphocytes.

Animals↗
PubMed1976

Electromanometric function test of the nasofrontal duct.

An electromanometric methods for the quantitative measurement of the ventilation of the frontal sinus is described which also measures the resistance of the nasofrontal duct to an experimentally produced hydrodynamic current. The biophysical basis as well as typical results of the examination are demonstrated and the field of clinical application in the differential diagnosis of frontal sinus affections is outlined.

Frontal Sinus↗
PubMed1976

[Angiodysplasia and the skeletal system].

1. Congenital angiodysplasias of the extremities are often associated with skeletal disorders, i.e., overgrowth (local giantism, hyperplasia) or reduced growth (hypoplasia). From a clinical point of view three types of combined lesions may be differentiated: (a) a secondary local giantism induced by hemodynamically active congenital a.v. fistulas, usually of intra- and extraosseous location (Weber-type); - (b) local giantism in combination with venous and/or lymphatic angiodysplasias; in this group skeletal overgrowth seems not to be caused by the vascular anomalies but represents more probably a coordinated "inborn error" of tissue composition and distribution (Klippel-Trenaunay-type); - (c) hemangiomatosis usually of venous (cavernous) type, affecting soft tissues as well as bones in association with skeletal hypoplasia. There is a retardation of bone growth by substitution and destruction of the epiphysial cartilages by the intraosseous hemangioma (Servelle-Martorelltype). In most cases (a-c) the use of special angiological investigations allows a clear diagnosis particularly concerning the pathogenesis of skeletal disorders. 2. In looking for an unequivocal terminology the clinical classification of these anomalies should be based on the leading clinical symptome, i.e., the giantism or the angiodysplasia. In this respect the vascular findings take on a predominant position. Paying regard to historical aspects the classification may be completed by the additional term "Klippel-Trenaunay" type, "Weber" type, "Servelle-Martorell" type. 3. An exact angiologic diagnosis gives further informations about prognosis and choice of treatment (group I: Early operative elimination or reduction of the a-v shuntvolume; group II and III: "wait and see!"; usually conservative treatment with compression bandages).

Angiomatosis↗