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Biomedical subjects

K Verma

Publications and source records attributed to K Verma.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

Interrelationship between bronchoalveolar lavage cellular constituents and pulmonary functions in sarcoidosis.

Bronchoalveolar lavage (BAL) using a fiberoptic bronchoscope was done in 36 patients with sarcoidosis on 45 occasions and in 19 control subjects over a period of seven years. Total cell, polymorphonuclear cell and eosinophil cell counts of bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis were not significantly different from control subjects. However, lymphocyte count (% total cells) in BALF was significantly higher (P less than 0.001) in patients with sarcoidosis as compared to control subjects. Alveolar macrophage was the predominant cell type in BALF in control subjects. A significant positive correlation (r = 0.46; P less than 0.01) between vital capacity (VC) and pulmonary diffusing capacity (DLCO) and a negative correlation (r = -0.52; P less than 0.001) between BAL fluid lymphocytes (%) and DLCO (per cent predicted) was found in patients with sarcoidosis. An increase in lymphocytes in BALF is considered to be one of the parameters indicating activity of sarcoidosis. In view of the relationship between this parameter and the reduction in DLCO, the latter may also be an indicator of disease activity.

Adolescent↗
PubMedDate not supplied

Bronchoalveolar lavage fluid (BALF) analysis in interstitial lung diseases--a 7-year experience.

Bronchoalveolar lavage (BAL) was performed in 89 patients with diffuse interstitial lung disorders of varied aetiology and 19 normal control subjects over a period of 7 years. Alveolar macrophage was the predominant cell in BALF in normal control subjects. Increased neutrophils were found in BALF in patients with cryptogenic fibrosing alveolitis (CFA) and fibrosing alveolitis associated with collagen vascular diseases. BALF lymphocytosis was seen in patients with chronic hypersensitivity pneumonitis, sarcoidosis, miliary tuberculosis, silicosis and carcinomatosis. Diagnosis of alveolar microlithiasis was made in one patient with the help of BALF examination. One patient developed anaphylactic reaction to the topical xylocaine solution and there was no mortality with the procedure.

Adult↗
PubMedDate not supplied

Gravid adult female worms of Wuchereria bancrofti in fine needle aspirates of soft tissue swellings. Report of three cases.

Gravid adult female worms of Wuchereria bancrofti were observed in fine needle aspirates of soft tissue swellings from three patients. An inguinal lymph node was aspirated in two cases, and a breast nodule was the site of aspiration in the third case. In one of the inguinal lymph node aspirates, two adult gravid female worms were identified.

Adolescent↗
PubMedDate not supplied

Value of fine needle aspiration cytology in the diagnosis of testicular neoplasms.

In 403 patients with a clinical suspicion of a testicular neoplasm, fine needle aspiration (FNA) was performed on the scrotal mass in 380 cases and on an extrascrotal swelling in 23 cases. There were 109 unsatisfactory aspirates. Fluid was aspirated in 50 cases, and only normal testicular elements were obtained in 82 cases. The aspirate showed an inflammatory lesion in 104 cases. A diagnosis of malignancy or suspicious for malignancy was given in 52 and 6 cases, respectively. Histopathologic confirmation of malignancy was available for 30 cases, for which the aspirate had been reported as malignant in 23, suspicious for malignancy in 3, unsatisfactory in 2 and negative for malignancy in 2. There were no false-positive FNA cytodiagnoses. No local seeding of tumor by the FNA procedure was observed. Typing of the testicular tumors on the aspirates showed a problem in classifying teratocarcinomas.

Biopsy, Needle↗
PubMedDate not supplied

Fine needle aspiration diagnosis of cysticercosis in soft tissue swellings.

The cytomorphologic criteria for diagnosing cysticercosis in fine needle aspirates are described. A retrospective analysis of aspirates from 62 cases with subcutaneous swellings in various sites showed the presence of the parasite in 25 cases. In another 31 cases, the aspiration smears contained no larval parts, but did contain an inflammatory reaction (consisting of large numbers of eosinophils and palasading histiocytes) suggestive of a parasitic cyst. Corresponding histologic material from 19 of these cases were diagnostic of cysticercosis in 9 cases and suggestive of cysticercosis in 10. However, histology was diagnostic of cysticercosis in six cases that produced acellular aspirates. These results show that fine needle aspiration cytology can diagnose or suggest cysticercosis in many cases, but may be falsely negative in a few.

Animals↗
PubMedDate not supplied

Immunoperoxidase detection of carcinoembryonic antigen in fine needle aspirates of breast carcinoma. Correlation with studies in tissue sections.

The peroxidase-antiperoxidase technique was used to demonstrate the presence of carcinoembryonic antigen (CEA) in fine needle aspirates and the corresponding tissue sections in 50 cases of carcinoma of the breast. The incidence of CEA positivity in the aspiration smears was 76%. A good correlation was observed between the results in the aspiration smears and in the tissue sections: 82% in the initial correlation and 90% when additional tissue sections from four of nine discordant cases proved to be positive for CEA. Five cases remained positive for CEA in the aspiration smears and negative for CEA in the tissue sections. This preliminary data indicates that aspiration smears can be used to demonstrate the CEA status in mammary carcinomas.

Biopsy, Needle↗
PubMedDate not supplied

Fine needle aspiration cytology of alveolar soft-part sarcoma. A case report.

A fine needle aspiration specimen from a mass in the thigh of a 25-year-old woman was submitted for cytologic examination. Malignant cells were found singly and in well-defined nests, resulting in an alveolar pattern. Individual cells were large, with moderate amounts of granular cytoplasm and vesicular nuclei with prominent nucleoli. The aspiration cytology findings plus the clinical setting suggested an alveolar soft-part sarcoma. Histologic and electron microscopic examination of the tumor mass confirmed the diagnosis.

Adult↗
PubMedDate not supplied

Cytologic examination as an adjunct to laparoscopy and guided biopsy in the diagnosis of hepatic and gallbladder neoplasia.

Laparoscopic examination guided biopsy and cytologic examination of samples obtained by aspiration, brush or scrape from the liver or gallbladder were performed on 26 patients suspected of having hepatic or gallbladder neoplasia. Laparoscopic findings were diagnostic of hepatic neoplasia (primary or secondary) in 13 cases and gallbladder carcinoma in 9 cases. The yields of positive diagnoses on biopsy alone, cytology alone and combined biopsy and cytology were 11 (84.6%), 11 (84.6%) and 12 (92.3%), respectively, in cases of hepatic neoplasia and 4 (44.4%), 5 (55.5%) and 5 (55.5%), respectively, in cases of gallbladder carcinoma. The cytologic typing concurred with the histologic typing in six of ten cases (60%) of hepatic neoplasia and all four cases (100%) of gallbladder carcinoma. It is suggested that cytologic examination be used as an adjunct to histologic examination of guided biopsies in the diagnosis of hepatic neoplasia. It is also concluded that it is possible to make a tissue diagnosis in patients with gallbladder carcinoma by obtaining material for cytology and biopsy through laparoscopy.

Adenocarcinoma↗