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Biomedical subjects

K Venkatesan

Publications and source records attributed to K Venkatesan.

At least 37 records · Page 2Linked to original sources
PubMed1982

Indirect assay of beta hydroxy beta methyl glutaryl CoA reductase in the sera of leprosy patients--a further probe into cholesterol metabolism.

With an aim to study the cholesterol biosynthetic capacity of the leprosy patients, the enzyme Beta hydroxy methyl glutaryl CoA reductase (HMG CoA) has been indirectly determined in the sera of leprosy patients and their family members by assaying the circulating levels of HMG CoA and mevalonate and finding out the ratio between two. The ratio was around 1 in leprosy patients indicating a normal HMG CoA reductase activity and approximately the same values were obtained in cases of healthy controls. The results suggest that cholesterol biosynthetic capacity of leprosy patients is normal. Whether cholesterol, the final product or intermediates like mevalonate are utilised by the invading M. leprae, thereby causing a lowered cholesterol level remains to be seen.

Cholesterol↗
PubMed1981

Systematic variation in bond lengths of peptides.

The lengths of the carbonyl as well as of the adjacent C-N and C-C bonds in peptides are shown to vary systematically with the central C-N bond length. Results of ab initio calculations on N-methylacetamide and its Li+, Na+ and Mg2+ complexes are also discussed.

Acetamides↗
PubMed1981

dl-17 beta-hydroxy-8 alpha-androst-4-en-3-one (8-isotestosterone).

The molecular conformation of dl-8-isotestosterone has been determined crystallographically. Crystals of the title compound belong to the space group P21/c with a = 11.449(4), b = 10.962(4), c = 25.860(5) A, beta = 100.95(4)o, with two molecules in the asymmetric unit. The structure has been refined to a final R value of 0.052 for 2227 reflections. Unlike testosterone, which is a flat molecule, its 8-isomer has a folded conformation. The conformations of the ring-B in the two crystallographically independent molecules (A and B) corresponded to the twist form and differ significantly from one another.

Chemical Phenomena↗
PubMed1981

Dapsone induced hypohaptoglobinemia in lepromatous leprosy patients.

Dapsone has been used in various dermatological disorders and in leprosy. One of the main side effects of dapsone therapy is anemia, mostly hemolytic. We aimed at finding the effect of dapsone therapy on serum haptoglobin levels which could be an indirect evidence for intravascular hemolysis, supported by secondary investigations such as liver functions (serum lactic dehydrogenase, alkaline phosphatase, bilirubin), blood hemoglobin levels, urinary excretion of urobilinogen, and erythrocytes. As in other infectious conditions, haptoglobins were raised in untreated lepromatous cases, compared to controls (p less than 0.05). Dapsone treatment of 100 mg daily for 14 days brought down the haptoglobin level significantly as compared to the untreated cases and the controls (p less than 0.05). An elevated alkaline phosphatase and lactate dehydrogenase indicate some liver dysfunction following dapsone therapy. A significant drop in blood hemoglobin level and a concomitant increase in serum bilirubin, urinary excretion of urobilinogen, and a significant fall in the serum hemoglobin binding capacity (haptoglobin level) following treatment with dapsone are quite suggestive of mild intravascular hemolysis.

Adult↗
PubMed1981

Renal functions in lepromatous leprosy patients.

While leprosy does not primarily affect the kidneys, secondary involvement of kidneys has been reported in lepromatous leprosy and especially in lepra-reaction. In the present study the authors have investigated the functional status of the kidneys of lepromatous leprosy patients by focussing attention to parameters like acidification of urine, glomerular filtration rate and excretion of a foreign dye administered intramuscularly. This study revealed a decreased ability to acidify urine and to excrete the dye as well as a drop in glomerular filtration rate in untreated LL patients. The said disturbances were more pronounced in lepra reaction.

Adult↗
PubMed1981

Serum protein bound fucose (PBF) in untreated leprosy patients.

Protein-Bound Fucose (PBF) content in sera from normal persons and untreated lepromatous or near lepromatous leprosy patients was measured and statistically analysed. Normal serum gave a mean value of 8.15 +/- 2.7 mg% and the sera of leprosy patients gave a value of 13.3 +/- 3.38%. The fucose contents in the glycoprotein and mucoprotein fractions were determined and found to increase in untreated leprosy patients. The values for ratio of fucose to protein also were found to be high in the sera of patients studied.

Adult↗
PubMed1980

Study on drug interactions.

Studies on the interactions of the drugs used in combination therapy of leprosy were attempted at this Institute. INH supplementation with clofazimine, therapy appeared to lower the skin levels of clofazimine, raising the plasma and urinary content of clofazimine. Concurrent administration of clofazimine with DDS does not appear to exert any influence on the excretion of DDS. The plasma DDS lowering effect of Rifampicin does not vary between fast and slow acetylators for DDS.

Adult↗
PubMed1979

Effect of ascorbic acid on blood levels of DDS.

A study was undertaken to probe into the influence of ascorbic acid on the absorption and metabolism of administered DDS in leprosy patients. Vit 'C' supplementation did not generally exhibit any effect on blood levels DDS except in cases of BB and LL where only 8 hrs DDS values showed a statistically significant increase.

Ascorbic Acid↗
PubMed1979

In vivo effect of DDS on phytohemagglutinin (PHA)-induced lymphocyte transformation cultures in normal healthy volunteers.

Depression in PHA-induced lymphocyte transformation in peripheral blood has been observed in 15 healthy volunteers after administration of DDS (100 mg/day) for seven days. In vitro culture of lymphocytes obtained from these volunteers in DDS-free normal AB serum has not altered the blast cell numbers. Lymphocytes of these volunteers have been found to contain a significant amount of DDS, ranging from 0.42 to 3.2 micrograms per 10.6 lymphocytes.

Dapsone↗
PubMed1978

Serum iron and total iron binding capacity in leprosy patients.

Serum Iron and Total Iron Binding capacity were estimated on the sera collected from 45 leprosy patients attending the out-patient department of the Central JALMA Institute for Leprosy, Agra. The Sera from 15 healthy subjects were included in the study as controls. Hypoferraemia was observed in lepromatous leprosy and was particularly marked during the reactive phase. Further investigations to elucidate the pathogenesis of anaemia in leprosy are being planned.

Anemia, Hypochromic↗
PubMed1978

Sequential biochemical investigations in lepromatous leprosy.

Sequential biochemical investigations were conducted in cases of lepromatous leprosy in the reactive as well as subsided phases. Low levels of blood sugar and serum cholesterol were indicated in the reactive phase of lepromatous leprosy. Significant increase in thymol turbidity and decrease in A/G ratio were noted in most of the cases of lepromatous leprosy. Enhancement of serum levels of transaminases was observed in the reactive phase of lepromatous leprosy. Serum protein electrophoresis indicated increases in alpha2--globulin and r--globulin and decrease in albumin in the reactive as well as subsided phases. The results are discussed in this paper.

Aspartate Aminotransferases↗