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K V Anderson

Publications and source records attributed to K V Anderson.

76 records · Page 5Linked to original sources
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Neuronal receptive field properties in feline nucleus reticularis gigantocellularis.

Nucleus reticularis gigantocellularis (NGC) has been shown, using both behavioral and physiological techniques, to be involved in the processing of nociceptive information. However, previous studies of the receptive fields of NGC neurons have utilized only innocuous stimuli. Thus, while neurons in NGC may play an important role in nociception, the receptive field properties of these cells remain to be defined. This investigation was designed to determine the receptive field properties of neurons in NGC using nociceptive and innocuous stimuli. Receptive fields were determined for 127 neurons in NGC. Eighty-seven percnet of the NGC neurons studied responded exclusively to noxious stimuli, while 13% also responded to innocuous stimuli. None of the neurons studied responded exclusively to innocuous stimuli. The receptive fields of most NGC neurons (63%) were large, discontinuous, and bilaterally symmetrical. Eighty-one percent of NGC neurons received convergent inputs from both spinal and trigeminal systems. These receptive field properties differ from those previously reported using only innocuous stimulation.

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Interactions between nucleus centrum medianum and gigantocellular nociceptive neurons.

Cells in nucleus reticularis gigantocellularis (NGC) and nucleus centrum medianum (CM) are known to respond to tooth pulp stimulation, which is a nociceptive trigeminal stimulus. We examined the effect of stimulation of CM on this class of neurons in NGC. Thirty-nine percent of the 57 neurons tested were antidromically activated by stimulation of the ipsilateral CM, while 28% of the 40 neurons tested were antidromically activated from the contralateral CM. In addition, the spontaneous activity of seven NGC neurons was altered by stimulation of the ipsilateral CM, while five cells were affected by stimulation of the contralateral CM. These data suggest a complex and reciprocal interaction between neurons in NGC and CM.

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Response of cells in feline nucleus centrum medianum to tooth pulp stimulation.

Nucleus centrum medianum (CM) has been implicated in the processing of nociceptive information based on behavioral, physiological and clinical data. Although the responses of neurons in CM have been extensively studied using spinal stimuli, few data are available concerning their responses to trigeminal stimuli. This investigation was designed to determine the responses of cells in CM to tooth pulp stimulation, which has been demonstrated to be an effective and relatively specific trigeminal nociceptive stimulus. Responses were recorded from 378 neurons in 38 pentobarbital-anesthetized cats. Most cells responded at a latency of 5 to 40 msec with one to six spikes for each stimulus. Cells in the dorsal portion of CM tended to respond only to maxillary teeth, while cells in the ventral portion of the nucleus tended to respond only to mandibular teeth. Cells in the central portion of CM generally responded to both maxillary and mandibular teeth. Cells in CM generally responded to both ipsilateral and contralateral teeth, without a preference for one side. These data differ from those reported using spinal stimulation, since a topographic organization has not been identified with spinal stimulation.

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