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Biomedical subjects

K Ueki

Publications and source records attributed to K Ueki.

At least 253 records · Page 14Linked to original sources
PubMed1978

[Immunological surveillance mechanism of a rat brain tumor model--study of time-lapse changes in the concomitant immunity of peripheral blood lymphocytes by microcytotoxicity assays (author's transl)].

A rat brain tumor model was prepared by semi-stereotactically implanting 1 x 10(6) RG--C6 tumor cells (chemically induced and maintained in vitro) in the right caudate nucleus of inbred WKA rat by a new method "Soft Agar Technique" which we developed. The tumor grew at a nearly fixed rate. We measured the maximum tumor area and the whole brain area of the rat brain which were sectioned coronary in series. We regarded the percentage of the tumor area to the whole area of the same section as tumor growth index. Microcytotoxicity assays of peripheral blood lymphocytes were performed at various stages of the tumor growth. RG--C6 cells were used as target cells, and they mixed with lymphocytes by Takasugi and Klein's method. Cytotoxicity index was higher in 22 cases (80.00 +/- 16.67; tumor growth index, 0--10) than in 28 cases of the control group (67. 25 +/- 19.68) and then gradually decreased with tumor growth (Fig. 2). At last cytotoxicity index went down to 41.55 +/- 24.94 in 11 cases (tumor growth index, over 31). These observations have a strong resemblance to other animal tumor models and suggest that the rat having brain tumor intra-axially have concomitant immunity especially in the first stage of tumor bearing.

Animals↗
PubMed1977

Angiographic appearance of a huge retrocerebellar arachnoid cyst in an infant.

A detailed analysis of the angiographic findings with a congenital retrocerebellar arachnoid cyst in an infant is reported. The angiographic features are a huge retrocerebellar extra-axial avascular mass compressing and displacing the fourth ventricle anteriorly, dysgenesis of the cerebellum, a tight posterior fossa and transtentorial upward herniation of the monticulus and brainstem.

Arachnoid↗
PubMed1977

Ultrastructural and biochemical studies on ouabain-induced oedematous brain.

Ouabain, a specific inhibitor of active cation transport across cell membrane, was applied topically to brain surface of cats. The cerebral cortex to which 10(3) M ouabain was applied showed a spongy state, which was ultrastructurally revealed to be swelling of the neuronal cell processes, especially of dendrites. Astrocytes did not show swelling even in the most severely affected lesions. There was a marked increase in sodium with a slight increase of water in the cortex treated with 10(3) M ouabain. No evidence of increased vascular permeability was noted in the cortex, morphologically or biochemically. Electron microscopic cytochemistry to detect the sodium ion revealed that the increased sodium in the cortex accumulated in the swollen neuronal cell processes. It is speculated that neuronal rather than astocytic elements might be highly dependent upon active cation transport, and that intracellular oedema in the brain tissue responsible for impairment of active cation transport might be related primarily to neuronal elements.

Animals↗
PubMed1976

[Determination of blood polyamines in patients with brain tumor -with special reference to relationship between varieties of tumors and concentrations of blood spermidine and spermine (author's transl)].

Examination of blood polyamines in 38 patients with brain tumor and 17 normal volunteers was carried out by columnar chromatography--cellulose acetate membrane electrophoresis. The upper limits of the normal values; M.+2S.D. of the blood polyamine concentrations in 17 normal volunteers, were less than 2.1 mg/ml for spermidine, less than 1.6 mg/ml for spermine, and less than 2.2 mg/ml for spermidine plus spermine. The values of blood polyamines in 21 cases with glioma were significantly higher than those in normal subjects (p less than 0.01). And in 14 out of them, the concentrations of the blood polyamines were higher than the maximum normal value. In one case with reticulum cell sarcoma, the concentrations of the blood polyamines were remarkably increased. In 2 out of 4 cases with metastatic brain tumor the concentration of the blood polyamines were higher than the upper limit of normal amount, and values of the blood polyamines in 4 cases with metastatic brain tumor were significantly higher than those in normal volunteers (p less than 0.05). In none of 2 cases with pituitary adenoma, 3 cases with meningioma, 4 cases with neurinoma, one case with hemangioblastoma, and one case with pinealoma, the values of the blood polyamines were significantly higher than those in normal volunteers. The CSF samples obtained from 9 patients with brain tumor, consisted of 6 gliomas (glioblastoma multiforme 2, anaplastic glioma 4), 1 teratoblastoma, 1 von Recklinghausen's disease (neurinoma and meningioma), and 1 craniopharyngioma, were analyzed for detection of polyamines, but no detectable amount was present in those cases.

Adult↗
PubMed1976

[A calvalial metastasis of alveolar soft part sarcoma (author's transl)].

The authors report and discuss a calvalial metastasis of alveolar soft part sarcoma which primarily developed in the left arm. A 13-year-old girl noted a painless tumor in the left upper arm at the age of 7 years. The tumor was excised and histologically alveolar soft part sarcoma. 5 years later, a rapid growing tumor was noted in the parietal area. The craniograms showed the left parietal bone defect. The chest X-ray showed a few large oval metastatic shadows. The left common carotid angiograms demonostrated high vascularities with irregular vessels in the arterial phase and a homogenous blush or stain in the venous phase. It was thought likely to meningioma. In selective external carotid angiograms, early arterial phase showed a few of vascular streaks in beads, fine tortuous vessels and early conspicuous filling of enlarged vein. Paradoxically, despite evidence of rapid shunting of blood from the lesion. "Wash out" of contrast media from the lesion was slow. Above mentioned angiographic appearance was consistent with that of cases reported by Rosenbaum, A.E., and was considered characteristic features of alveolar soft part sarcoma, meningiosarcoma and malignant melanoma. It must be emphasized that the slective angiography is important to differentiate angiographically alveolar soft part sarcoma, meningiosarcoma, malignant melanoma from meningioma or angioma. Radiotherapy is not effective to the pulmonary metastatic lesion. Selective angiography should be emphazied to be essential for differentiation of alveolar soft part sarcoma from angioma or meningioma.

Adolescent↗
PubMed1976

[Radiation therapy and surgical management of pineal tumors--follow-up study of 96 patients (author's transl)].

This is a follow-up study of 96 patients with pineal tumors, except for one patient who was lost to follow-up. 60 of these tumors were verified histologically either at operation or at necropsy, 6 were diagnosed by epitheloid cells existing in the cerebrospinal fluid, and 30 were diagnosed by clinical and ventriculographic findings. In agreement with Russell and Rubinstein, we have classified the histologically verified tumors into 3 groups, as follows; 1. True Pinealoma Group (Pineocytoma, Pineoblastoma), 2. Germinoma-Teratoma Group, 3. Others (Glioma, Cyst). The following points need to be emphasized in the planning of management: 1. Pinealoma (Two cell pattern pinealoma) responds favorably to radiation therapy. 18 of 43 patients of pinealomas who were treated with irradiation are functioning normally in various life situations for more than 5 years. Among them, 5 cases of pinealomas treated with irradiation alone have more than 10 years survivals. 2. There is a limitation in the efficacy of irradiation therapy in cases of spinal cord implantation, infiltration in adjacent structures or subependymal infiltration along the ventricular cavity. 3. Only 2 of 67 patients with pinealomas had spinal cord metastasis. It seems undesirable to subject all patients to complete cerebrospinal axis irradiation. 4. Successful removal were performed in 4 patients with teratomas and are now alive for 9-21 years. None of them, however, are doing well clinically with many neurological deficits. 5. Since adenocarcinoma, teratocarcinoma, teratoblastoma and others are not sensitive to radiation therapy, only the palliative treatments are available. 6. Therefore, the most promising treatments for pineal tumors is that irradiation, plus shunting operation when required, is a first choice and after irradiation, radical removal should be tried in the case of teratoma diagnosed by clinical and ventriculographic findings.

Adenocarcinoma↗