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Biomedical subjects

K Tucker

Publications and source records attributed to K Tucker.

At least 73 records · Page 4Linked to original sources
PubMed1992

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin.

The antitumor activities of immunotoxins (ITs) constructed with deglycosylated ricin A chain (dgA) and either anti-CD19 (HD37) or anti-CD22 (RFB4) monoclonal antibodies were compared in SCID mice with disseminated human Daudi lymphoma (SCID/Daudi). As reported previously, after intravenous injection with Daudi cells, SCID mice develop disseminated lymphoma, which infiltrates the vertebral column and causes paralysis of the hind legs before death. The mean paralysis time (MPT) has been taken as an end point in this tumor model. We have previously reported that early treatment of SCID/Daudi mice with RFB4 coupled to dgA prolongs the MPT in a manner consistent with the killing of 4 logs of tumor cells. In the present study, we show that HD37-dgA kills 2 logs of tumor cells. The lower potency of the HD37-dgA is consistent with its lower IC50 on Daudi cells in vitro. We further show that the antitumor activity of a mixture of HD37-dgA and RFB4-dgA is significantly enhanced in SCID/Daudi mice and is consistent with the killing in excess of 5 logs of tumor cells. However, identical enhancement was observed when a mixture of the RFB4-dgA and the HD37 antibody was administered. In contrast, enhancement was not observed when mice were injected with a mixture of the RFB4 antibody and the HD37-dgA. The results indicate that a "cocktail" of HD37 antibody and RFB4-dgA immunotoxin can have significant antitumor activity in this mouse model of lymphoma and suggest that combinations of particular antibodies and ITs may have cooperative antitumor activity.

Animals↗
PubMed1988

Maternal employment and child nutrition in Panama.

The major question addressed in this research is: 'Does maternal employment affect child dietary intake and nutritional status and if so, what mediating factors are important?' Maternal employment has been seen to have two conflicting effects on child nutrition--via increased income and decreased time available in the household. Efficiency and preferences of the household will vary and are likely to be of major importance in these relationships. A comprehensive measure of these inputs was devised using the concept of 'differentiation', defined as the capacity to process a diversity of information types. Various indicators of this concept were identified at both the household and the maternal levels and entered into a principal component analysis which generated composite variables. The data, including weighed dietary intakes and observed time use for mothers and substitutes, were collected during a 1 year stay in Panama. The results of a series of stepwise and multiple regression analyses lead to the conclusion that maternal employment, in this population, has a positive effect on child nutrition. In most cases, employment status enters into interactions with a variety of effect modifiers, suggesting the highly situational aspect of the relationships. Maternal time in home production decreases with her employment but total household time in these activities does not, due to the inputs of other household members. Maternal income seems to be of key importance to dietary intake. The maternal differentiation variable is consistently and positively related to dietary and anthropometric outcomes.(ABSTRACT TRUNCATED AT 250 WORDS)

Anthropometry↗
PubMed1988

Intestinal helminthiases in relation to the socioeconomic environment of Panamanian children.

A cross-sectional investigation was made into ascariasis and nutritional status in Panamanian preschool children from October 1983 to July 1984. Within this framework, an analysis was undertaken of possible relationships between a range of intestinal helminthiases and the socioeconomic status of the participants. Attention was paid to caregiver's education, parental occupation, family earnings, quality of housing and sanitation in the assessment of socioeconomic status. On this basis, strong associations were established between the socioeconomic status of the children and infection with Ascaris lumbricoides, Trichuris trichiura and hookworm. In general, the prevalence of single and multiple helminth infections was significantly higher in children living in housing made of wood or bamboo than in those living in housing made of concrete blocks. The same pattern applied to levels of sanitation. Ascaris lumbricoides occurred more frequently in children of mothers with the least formal education and in children living in relatively crowded conditions. Evidence was also obtained to indicate that the intensity of the intestinal helminth infections was greater in the children from the poorer environment. Since children from poorer socioeconomic conditions might be more exposed to infective stages than those from a better environment, the possible role of socioeconomic factors in contributing to the predisposition of some individuals to harbour large worm burdens of intestinal helminths was briefly discussed.

Ascariasis↗
PubMed1987

Contributions of ascariasis to poor nutritional status in children from Chiriqui Province, Republic of Panama.

Relationships between ascariasis and lactose digestion and between ascariasis and food transit time from mouth to caecum were investigated in young children from Chiriqui Province, Republic of Panama. The breath hydrogen method was used in both studies. Ascaris-infected children showed a significantly poorer degree of lactose digestion following a test oral load than uninfected children. Recovery of the capacity of the children to digest lactose was still not fully complete for at least 3 weeks following anthelmintic treatment. On average, the mouth-to-caecum transit time was similar in infected and uninfected children, but among the Ascaris-infected children the transit time tended to be shorter in relation to the intensity of infection. Evidence from a cross-sectional survey indicated that ascariasis was significantly associated with reduced plasma vitamin A and carotenoid concentrations. This relationship remained after controlling for a range of socio-economic variables. Ascaris-infected children were frequently found to have lower haematocrits and blood haemoglobin concentrations than uninfected children, but these relationships could not be attributed to ascariasis alone.

Anthropometry↗
PubMed1987

Ascaris lumbricoides infection in pre-school children from Chiriqui Province, Panama.

An epidemiological survey of intestinal parasitic infections was conducted in a sample of 203 children aged 3-5 years from a semi-urban and a rural community in Chiriqui, Panama, in 1983-4. On the basis of stool examinations, the prevalences of Ascaris lumbricoides, Trichuris trichiura, hookworm, Giardia intestinalis, Entamoeba spp. and Strongyloides stercoralis were found to be 27, 34, 14, 15, 5 and 4% respectively. The results from children from the two communities were compared. Polyparasitism occurred significantly more often in rural than semi-urban children. Following anthelmintic treatment with levamisole, the numbers of A. lumbricoides passed/child were recorded and the frequency distribution of the parasite was observed to be highly aggregated with a variance to mean ratio of 10.2. For A. lumbricoides, relationships between worm burden, worm biomass and egg production were investigated. In the data analysis, an attempt was made to explore the influence of numbers of male worms on egg production. The results are compared with those obtained during other recent studies on the epidemiology of A. lumbricoides infection in other countries.

Animals↗
PubMed1978

Some aspects of post-traumatic elbow stiffness.

In this article the anatomy of the soft tissues around the elbow joint is described in relation to the causation of post-traumatic elbow stiffness. Examples of the ways in which significant damage to these tissues may occur after injury are discussed. It is suggested how arthrography may help in the diagnosis of the condition.

Connective Tissue↗
PubMed1975

The Tower of London bomb explosion.

After the detonation of a bomb in the Tower of London 37 people were brought to St. Bartholomew's Hospital. The explosion caused numerous severe injuries of a type rarely seen in peacetime.

Abdominal Injuries↗
PubMedDate not supplied

Epidemic optic and peripheral neuropathy in Cuba: a unique geopolitical public health problem.

During 1992 and 1993 an epidemic of optic and peripheral neuropathy affected over 50,000 Cubans. This occurred in the unique setting of a communist country which had a widespread health care network and wherein sudden changes in the economy affected most of the population. Although nutritional factors appeared to play a key role in the pathogenesis of the epidemic neuropathy, viral, toxic, and genetic factors were investigated by Cuban and North American scientists. The authors, representing different disciplines and different groups that visited Cuba during the epidemic, review and reflect on the clinical and laboratory findings which became available through their own experience and through reviewing the literature. The recent Cuban epidemic is compared to similar outbreaks of optic and peripheral neuropathy which have occurred in the past.

Alcohol Drinking↗
PubMedDate not supplied

Psychological impact of genetic counselling and testing in women previously diagnosed with breast cancer.

BACKGROUND: The recent discovery of susceptibility genes relating to breast cancer, BRCA1 and BRCA2, now allows women with breast cancer and a family history of breast/ovarian cancer to undergo genetic testing to identify a causative germ-line mutation. The present study assessed the psychological status over time of women affected by breast cancer requesting genetic testing (cases; n = 32) compared with matched controls (n = 28). METHODS: Subjects were recruited through two Sydney-based hospitals. Data were collected via questionnaire and telephone interview at baseline, and 2 weeks and 3-6 months following counselling. RESULTS: Genetic test results were not received by the subjects within the study period. Cases showed a greater increase in knowledge of cancer genetics following counselling compared with controls, and this was maintained over time. Psychological symptoms remained stable over the study period and there were no differences between groups. CONCLUSIONS: Increased knowledge following genetic counselling was not accompanied by an increase in anxiety or depression. Further assessment will be required in the long term to determine the psychological impact of receiving a genetic test result.

Adult↗