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Biomedical subjects

K Tsuchiya

Publications and source records attributed to K Tsuchiya.

At least 523 records · Page 29Linked to original sources
PubMed1986

[Analyses of industrial society from ecology--modeling analyses of industrial ecological system].

A macroscopic industrial ecological model has been developed to investigate the effects of changes in industrial structure on social well-being in general and health in particular. The model is composed of the following sectors: industry and employment, environment and pollution, and population and health care. The model was calibrated using available data of the past 60 years for Japan. The simulation study was conducted with the time span of 1920 to 2000. The results indicated that the gradual shift, in the industrial structure of Japan, would improve the level of living standards resulting in enhanced health service capability and lower death rate although increasing adult disease rates in the aged society. Also the rapid future growths of service industry and information and communication were observed.

Ecology↗
PubMed1986

Early detection and signs of hepatoangiosarcoma among vinyl chloride workers.

Health examinations of 108 workers exposed to vinyl chloride monomer (VCM) at a Japanese chemical plant were carried out in 1979. The polymerization of vinyl chloride was started at the plant in 1949. In this study, the highest concentration of VCM in autoclaves was determined to be 250 ppm in 1961. However, the workers at the plant had been exposed to higher concentrations of VCM several times before 1960. More recent VCM exposure was considered negligible. Examinations assessed data on age, height, weight, obesity index, sake consumption, VCM exposure concentration, latent period, cumulative exposure, ICG (indocyano green test), serum bilirubin, GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), A1-P (alkaline phosphatase), GGT(gamma-glutamyl transpeptidase), ZTT (zinc turbidity test), LDH (lactate dehydrogenase), cholesterol, TTT (thymol turbidity test), A/G (albumin globulin ratio), and thrombocytes. Variation in VCM exposure did not affect tests of pigment excretion from the liver, such as ICG; thrombocytes; and enzyme activity (such as GPT); nor bilirubin or flocculation reaction in serum.

Adult↗
PubMed1986

Pharmacokinetics of SCE-1141, a stereoisomer of cefmenoxime, in rats.

The pharmacokinetic properties of SCE-1141, an anti stereoisomer of cefmenoxime, were compared with those of cefmenoxime. SCE-1141 levels in plasma and tissues peaked at 30 min after the intramuscular administration of 20 mg/kg; the plasma level declined with a half-life of about 18 min. The area under the concentration-time curve in plasma and the half-life after intravenous administration were similar to those after intramuscular administration. SCE-1141 was distributed at high concentrations in the liver and kidney of normal rats, and at lower concentrations in the liver of rats with acute liver impairment. SCE-1141 levels in plasma and tissues, except liver, were lower than those of cefmenoxime. The 24-h biliary and urinary excretions of SCE-1141 were 73% and 26% of the dose, respectively; these were significantly different from those of cefmenoxime: 33% in bile and 55% in urine. In rats with acute liver impairment, the biliary excretion of SCE-1141 was decreased, and the urinary excretion increased.

Animals↗
PubMed1986

Lichenoid tissue reaction induced by local transfer of Ia-reactive T-cell clones.

Epidermal basal cell damage in lichenoid tissue reactions (LTR) is considered to be the result of immunologic injury. In this study, we propose that LTR may be caused by local activation of Ia-reactive T cells. We have established allo-Iak-reactive helper T-cell clones and examined their behavior after adoptive transfer. We show that local transfer of 3 allo-Iak-reactive helper T-cell clones with different cross-reactivities and functions in vitro can cause delayed type hypersensitivity (DTH) reactions in vivo with antigen specificities identical to those demonstrated in vitro. Clone SK.1, when injected into appropriate recipients, caused massive dermal infiltrates of neutrophils and mononuclear cells. The latter were attracted to the epidermis and induced LTR-like basal cell degeneration which peaked at 72 h. Appropriate recipients were those strains of mice whose spleen cells were able to stimulate SK.1 cells to proliferate in vitro. Two other clones, SK.2.18 and SK.2.16, evoked significant DTH responses in their appropriate recipients, but the massive cellular infiltrates induced by either clone never invaded the epidermis or produced an LTR. The degeneration of epidermal cells caused by SK.1 cells did not correlate with the tested functions of this clone in vitro. The finding that only 1 of the 3 allo-Ia-reactive helper T-cell clones induced epidermotropic cellular infiltrates indicates that the infiltrative pattern of leukocytes in skin may depend on the particular T-cell clone that is activated.

Animals↗
PubMed1986

Single photon emission computed tomography of brain tumors with 201TIC1.

Single photon emission computed tomography (SPECT) with 201TIC1 was performed in 27 patients with brain tumors. Findings on SPECT were compared with those on planar images, computed tomography (CT) and, in 4 cases, magnetic resonance imaging (MRI). At SPECT the tumors were shown as areas with higher accumulation of the tracers than the surrounding brain tissue in 24 cases and a better discrimination was obtained than in planar images. Deep-seated lesions were especially visualized. In some cases SPECT defined lesions that were not clearly delineated on CT or MRI. SPECT with 201TlCl can be of clinical use in the diagnosis of brain tumors.

Brain Neoplasms↗
PubMed1986

[The effects of serum from tumor-bearing mice on mitogen-induced blastogenesis of normal spleen cells].

In order to detect the serum immunosuppressive factors of tumor bearer, the effects of normal C3H/He mice serum (NMS), serum from methylcholanthrene induced fibrosarcoma bearing mice (F4w serum) and sera fractionated by high performance liquid chromatography (HPLC) using anion exchange column were examined on mitogen-induced blastogenesis of normal murine spleen cells (Nspc). The addition of 5% of NMS suppressed the blastogenesis of Nspc. Less than 0.6% of F4w serum suppressed the blastogenesis. NMS was applied to HPLC and was separated to four peaks (A,B,C,D). In HPLC pattern of F4w serum, peak B was higher than that of NMS and new peak (E) was observed next to peak D. Peak D of NMS suppressed the blastogenesis. Not peak D but peak E of F4w serum suppressed the blastogenesis. The properties of those blastogenesis-suppressive fractions were discussed.

Animals↗