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Biomedical subjects

K Troshev

Publications and source records attributed to K Troshev.

At least 19 recordsLinked to original sources
PubMed1997

Bacteriostatic and biological stimulation effect of Mepitel on experimental burns on the skin of rats.

This study was conducted on 200 white Wistar rats weighing about 200 g each. The animals were divided into two equal groups--an experimental one, with Mepitel (SCA Mölnlycke) dressings, and a control group with cotton gauze dressings. Microbiological and histological examinations and measurements of the wounds made on the 3rd, 7th, 14th, 21st and 28th days after the 3rd-degree heat burn was inflicted using the standard method. The observations included burns with the spontaneous elimination of necroses and healing; wounds after operative total necrectomy of the burnt skin and spontaneous healing; and burns followed by total surgical necrectomy and grafting with allotransplants. The quantitative results reveal statistically reliable bacteriostatic activity above and under the Mepitel dressing. The histological examination reveals considerable biological activity in the tissues under the Mepitel. This manifests itself as an acceleration in the healing process in the wounds caused by burns and after necrectomy of the burnt skin. Mepitel on the allotransplant on the wound, which was left following the necrectomy of the burnt skin provokes the rapid and early rejection of the allograft. Mepitel's biological activity has also been confirmed by the statistically-reliable data relating to the dynamic changes in the length and breadth of the wounds. The authors came to the conclusion that, when applied immediately to a burn or a wound left following the necrectomy of skin burns, Mepitel suppresses the development of the microbiological flora and stimulates the normal healing process. Mepitel is not suitable for dressing allotransplants because of the rapid acceleration of their rejection.

Animals↗
PubMed1994

Tactics of sparing activity during the acute period of severe burns.

The authors make an analysis of the acute period and treatment of severe burns affecting over 50% of body surface. In our cases we used a SAPEX fluid bed. All patients were surgically treated after the acute period. The characteristics of intensive care include infusion of a large amount of solutions to attain an abundant diurrhesis of 100 ml per hour. Rehabilitation with respiratory exercises and isometric complexes starts at the beginning of the second twenty four hour period. Tactics of sparing activity are widely used in our clinical practice during the last years. Using it we managed to cure 10 patients with over 80% of burned body surface.

Acute-Phase Reaction↗
PubMed1993

[The area around the wound in experimental chemical injuries to the skin].

This is an experimental assessment of the morphological patterns of skin in the area surrounding wounds, produced by exposure to sodium base, sulfuric acid and hydrochloric acid. The changes are followed up from 6th hour to 28th post-injury day, and compared with those in the skin surrounding thermal burns using the same experimental setup. The differences in healing processes, both by comparison with the control group, and between the individual chemical agents, are insignificant. Following chemical injury as well, nonspecific tissue healing processes develop in the area around the wound. The diagnostic and therapeutic problems faced, and the potentials in the wound area after chemical lesions are similar to those following other types of skin damage.

Animals↗
PubMed1993

[The experimental and clinical use of neprolizin in thermal burns of the skin].

Morphological skin changes within the focus of lesion and in the perilesional area are studied against the background of local application of the Bulgarian enzyme preparation Neprolyzin. The experimentally induced injury includes thermal burn, mechanical crushing (conquassatio), and combination of the two. The drug is administered immediately after the trauma, or on the fourth post-injury day, with the studies performed after 4-day-long treatment. In the clinical trial Neprolyzin is applied within 3 to 4 days of a third-degree burn. In conclusion, it is stressed that Neprolyzin should be applied immediately after a thermal burn, it should not be used in handling a mechanical crush injury, whereas in the event of associated trauma it should be used on the fourth post-injury day. The clinical assessment points to the necessity of local anesthesia during application of the drug, or analgesics up to one hour after the dressing.

Animals↗
PubMed1993

[The effect of temporary skin substitutes on the area around the wound following an experimental thermal burn of the skin].

The effect of temporary skin resurfacing on processes developing in the skin surrounding post-thermal-burn wounds is morphologically studied in experiment. The burned wound region and perilesional area are immediately covered by a fresh allograft, xenograft, Ampoxen, Pharmexplant and Deflamol ointment. Tissue specimens for histological evaluation are taken within 3, 7 and 14 days. The processes developing within the wound and in the perilesional area under a fresh allograft and Deflamol ointment appear to be the most beneficial. Here the inflammatory response is substantially milder, and regardless of the latter, the regeneration and even differentiation of cells in the course of healing are more clearcut, as compared to the other resurfacing methods used in the experiment.

Animals↗
PubMed1993

[Methods for the experimental study of the area around a traumatic skin wound].

The author describes the methods for experimental study of the area around a traumatic skin wound, which up to now have been neglected by the hospital doctors and the investigators. The choice of the experimental animals and the methods for the preliminary preparatory work with them have been described. The author in details specifies the ways of injuring the skin--by thermal burn, mechanical crushing and combination of both, chemical injury and incision wound. All the manipulations of wounds are treated in inhalation ether anaesthesia. The methods proposed ensures replications and makes the results precise and sure. This fact gives the opportunity for usage of the methods for assessment and analysis of medicinal preparations and other means for treatment of wounds. The methods was created and used in experiments with 1200 experimental animals.

Animals↗
PubMed1993

[An experimental study of chemical necrectomy in chemical injuries of the skin].

The authors studied experimentally the morphological changes of injuries and the surrounding areas after a skin chemical injury caused by sodium hydroxide, sulphuric acid and chlorhydric acid under the influence of acidic necrolytics--40% benzoic acid and 40% salycilic acid in unguentus. The necrolytics are applied on the injured areas immediately upon getting the wound or on the 4th day thereafter, while the morphological study is carried out after getting off the necrosis. It has been established that the necrolysis in the case of sodium hydroxide was not effected by the 28th day. The processes in the tissues upon acidic injuries do not differ from the spontaneous healing process.

Animals↗
PubMed1990

Regulation of traumatic skin wound healing by influencing the process in the neighbouring zone of the wound.

After the burn, the authors immediately applied the albuminous hydrolysate Hydropot, a propolis-urea ointment and Trypsin compresses (3,500 E) to the burned area and its vicinity, and repeated this procedure for several days. Samples for histological examination were taken after the animals' decapitation every 2 hrs. and on the 3rd, 5th and 14th post-injury days. The morphological picture showed a difference in rate and quality of regeneration. The authors are of the opinion that the processes occurring in the neighbourhood of the traumatic skin wound can be influenced and that regeneration can be regulated.

Albumins↗