[Fundamental and clinical evaluation of a magnetic T3 radioimmunoassay kit].
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Biomedical subjects
Publications and source records attributed to K Torizuka.
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The quantitative measurement of regional blood flow and regional extravascular lung water, called for a design of 15O labeled water production and administration under continuous and constant flow. In our search for simple methodology, suitable for clinical routine facilities, two remote-controlled systems were designed and their applicability for continuous and constant infusion of H215O were tested. In system (A), H215O was prepared from C15O2 based on the fast exchange reaction between carbon dioxide and carbonic acid. In the system (B), the reaction of 15O2 with H2 using palladium as a catalyst was adopted. In the both systems, the radioactivity level of the infusate was kept constant by using a buffer reservoir. Clinical applicability of both fully automated systems for the production of sterile H215O at a continuous and constant rate was discussed. Namely, system (A), being very simple seems more suitable for any closely located facility but system (B) is more suited for the production of higher radioactivity.
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We correlated scintigraphy and histological findings in 40 cases of nodular goiter in which two or more kinds of scintigraphy were performed preoperatively. 201Tl scintigraphy for imaging thyroid carcinoma showed a diagnostic agreement of 80% for thyroid lesions and 82% for metastatic lesions in the cervical lymph nodes. These agreements were higher than with 99mTc-bleomycin scintigraphy. Thus, 201Tl scan can be used to evaluate 'cold' thyroid nodules and to visualize metastatic lesions. 201Tl scan was also found valuable as a diagnostic measure for local recurrence of thyroid carcinoma. However, there were a few false-positive and false-negative results.
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To evaluate upper urinary tract and ileal loop functions, dynamic urinary flow studies using I-123 hippuran were performed in 52 kidneys of 27 patients with ileal loop urinary diversion. Analysis of regional renograms enabled easy assessment of the cortical, pelvic and loop functions. Normal pattern was found in 33 cortices (63.5%), 22 pelvis (45.8%) and 14 loops (51.9%). Most of the abnormal findings in the upper urinary tract were delayed excretion and/or retention of the pelvic and ureteral urines. Diagnosis of ileoureteral reflux under normal physiological circumstances was made to compare the pelvic and loop curves. Small peaks and/or irregular spike waves observed in the down slope of the pelvic curve concurrently with the increased activity of the loop curve indicate a production of the ileoureteral reflux associated with ileal movement. This reflux was noted in 22 of the 27 cases (81.5%). Bilateral reflux was evident in 3 cases, and unilateral reflux in 19 cases. Ileoureteral reflux was noticed in 14 of the 15 cases (90%) in which retrograde loopography was performed. Although bilateral reflux was found in 8 cases, the hippuran study revealed bilateral in only one case, unilateral in 5 and no reflux in 2. Thus, I-123 hippuran scintigraphy consisting of sequential renal images, loopograms and regional renograms enables the diagnosis of ileoureteral reflux and obstructive uropathies and is a useful tool to detect functional complications of the upper urinary tract in patients with ileal loop diversion.
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