Biomedical subjects
K Torikai
Publications and source records attributed to K Torikai.
[Evaluation of two quantitative tests for salivary secretion--the chewing gum test and the Saxon test in normal subjects and in patients with Sjögren's syndrome].
A cooperative multicenter study was performed to evaluate two salivary secretion methods-the chewing gum test and the Saxon test by a crossover method. Twenty healthy volunteers and 27 patients with Sjögren's syndrome were examined. In healthy controls the amount of saliva collected per minute was larger in the Saxon test. Both tests revealed a significant decrease of salivary secretion in patients with Sjögren's syndrome, but the amount of saliva per minute was also larger in Saxon test. By repeated trials of both tests a notable increase of saliva was always observed at the second trial. Since this phenomenon may be due to the learning effect of the tests, one should perform at least one practice before starting formal tests. Saxon test could be performed in a patient having dental prostheses who was unable to masticate chewing gum. The Saxon test, thus, may be an efficient method, to evaluate the salivary secretory function.
[Countermeasure for adverse effects of therapeutic agents for systemic lupus erythematosus].
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[Serological and immunohistochemical studies in pregnant women with systemic lupus erythematosus].
The present report is a detailed, prospective analysis of 29 pregnancies in 19 patients with systemic lupus erythematosus (SLE). The clinical pregnant status was correlated with maternal serologic patterns. Poor obstetrical prognosis was associated with low or declining complement (C3 and C4) levels and rising antinuclear and anti-DNA antibody titers. Complement levels reflected clinical changes more accurately than either antinuclear factor. A smooth antepartum course and successful delivery occurred when complement values remained normal. Immunohistochemical studies showed granular or linear depositions of immunoglobulin and complement on syncytial trophoblast and stromal tissue in placenta with SLE. Slight deposits of IgG were observed on the stromal tissue in normal placenta. Immune complex deposition on the trophoblast correlated to both serologic evaluation and course of SLE pregnancy. Obstetrical prognosis can be evaluated by serial determinations of serologic status. These data suggest that declining levels of maternal complements in SLE may be partly due to immune complex deposition in the placenta, resulting in the increased placental dysfunction.
A new autoantibody in patients with rheumatoid arthritis: characterization of the anti-HaT-1 antibody system.
A unique, new autoantibody, anti-HaT-1, has been identified in the serum of patients with rheumatoid arthritis (RA). Anti-HaT-1 antibody is predominantly IgM, and reacts by double immunodiffusion with HaT-1 antigen, an acidic protein in human and rat liver supernatant (MW approximately 150,000). It was detected in 9 of 38 patients with RA, 2 of 15 patients with RA and Sjögren's syndrome, and none of 92 patients with other connective tissue diseases, indicating that this autoantibody is highly specific for RA.
[Evaluation of T-2588 in the treatment of respiratory tract infection].
T-2588 was used on 55 patients with respiratory tract infections and 44 cases were evaluated; 23 patients with pneumonia, 12 patients with acute bronchitis, 2 patients with chronic bronchitis, 1 patient with diffuse panbronchiolitis and 6 patients with bronchiectasis with infection. Clinical effects of T-2588 were as follows; excellent in 6 and good in 28 patients. The efficacy rate was 77.3% (34/44). Bacteriological effects of T-2588 were prominent in 8 patients infected with B. catarrhalis, H. influenzae, K. pneumoniae and E. coli, but not in a patient infected with P. putida. The elimination rate was 90.0% (9/10 strains). As side effects, stomatitis, anorexia, diarrhea X vomiting and pruritus were observed in one patient each. Abnormal laboratory findings were observed in 4 patients with elevated GOT and/or GPT. These side effects and abnormal laboratory findings were not serious. The usefulness of T-2588 was 68.2% (30/44). Therefore, T-2588 is a useful drug and its effects are promising in clinical management of respiratory tract infections.
Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus.
Collagenase-like (CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjögren's syndrome.
Repair of ptosis possibly attributable to the long-term wearing of a contact lens.
In recent years contact lenses have become more popular from the ophthalmological viewpoint and because they are easy to wear and aesthetically more acceptable than eyeglasses. One of the complications produced by wearing contact lenses, however, is ptosis. We have had a patient with ptosis possibly due to the long-term wearing of a contact lens in one eye. We performed a skin resection together with repair of the aponeurosis of the levator muscle of the upper eyelid. According to our investigations, there has been only one report on the repair of aponeurosis of the levator muscle of the upper eyelid for this type of problem, and the approach and findings were similar to ours.
[Disease specificity of anti-SS.A antibody].
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Sialographic study in patients with and without antibodies to Sjögren's syndrome A (Ro).
Antibodies to Sjögren's syndrome A (SS-A) (Ro) antigen were detected in 13 of 16 (81%) patients with sicca alone and 18 of 34 (54%) patients with systemic lupus erythematosus (SLE). Antibodies to Sjögren's syndrome B (SS-B) (La, Ha) antigen were detected in 7 of 16 (44%) patients with sicca alone. These percentages were statistically higher than those in other types of connective tissue diseases. There were no direct correlations between titers of antibodies to SS-A (Ro) and severity of sialographic abnormalities in 35 patients with Sjögren's syndrome (SS). However comparison of a total of 20 sialograms obtained from patients with antibodies to SS-A (Ro) showed more advanced changes than in a total of 36 sialograms from patients without antibodies to SS-A (Ro) in systemic lupus erythematosus, mixed connective tissue disease, progressive systemic sclerosis and rheumatoid arthritis. These results suggested that antibody to SS-A (Ro) may be a good indicator of subclinical SS.
[Clinical description and nursing of SLE (systemic lupus erythematosus). Immunosuppressive therapy of SLE].
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[Four cases of Sjögren's syndrome having erythematous cutaneous manifestations (author's transl)].
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[A case of mixed connective tissue disease in childhood with symptoms of juvenile rheumatoid arthritis (author's transl)].
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[A case of macroglobulinemia masquerading as orbital pseudolymphoma (author's transl)].
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The fundamental studies on antituberculous activities of lividomycin.
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Properties of light particles produced during growth of Type 4 adeno-associated satellite virus.
Adeno-associated satellite virus type 4, obtained by repeated undiluted passage, failed to produce distinct bands at the expected density of 1.43 g/cm(3) after density gradient centrifugation in CsCl. This phenomenon occurred regardless of the hemagglutinating activity of the starting material. Sharp bands were found at a density of 1.34 to 1.35 g/cm(3). These bands contained adenovirions and numerous satellite particles. These latter particles could be distinguished by electron microscopy from standard dense satellite particles by their flattened profiles and deep penetration of negative stains. Dense bands of satellite virus at 1.43 g/cm(3) were constantly observed when the inoculum was comprised of highly diluted seed virus. Light satellite particles had a particle to HA ratio comparable with dense particles, but possessed low infectivity. Measurements of contour lengths of extracted deoxyribonucleic acid (DNA) indicate that light particles contain only a small amount of DNA, possibly less than 0.5 x 10(6) daltons, compared to 1.4 x 10(6) for the complete satellite DNA molecule.
Immunologic detection of single-stranded DNA in adeno-associated satellite virions.
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