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Biomedical subjects

K Tinaztepe

Publications and source records attributed to K Tinaztepe.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Clinicopathological conference: an 11-year-old boy with recurrent infections, hypertension, skin rash, and nephritic syndrome.

In this clinicopathological conference, an 11-year old boy who presented with recurrent pyogenic infections, hypertension, malar rash, various skin lesions and nephritic syndrome since five years of age is discussed. He was hospitalized for clinical investigation with skin and renal biopsies at 10 years of age. Using clinicopathological data obtained from his last admission, a clinical diagnosis was reached, and the disorders of the complement system causing patients to show these signs or symptoms are emphasized. At the end of the discussion, a clinicopathological correlation is given for making the diagnosis.

Child↗
PubMedDate not supplied

Apoptosis in renal disease: a brief review of the literature and report of preliminary findings in childhood lupus nephritis.

Apoptosis, a programmed form of cell death, is an important mechanism that maintains cellular homeostasis. The cellular content of tissues is regulated by a balance between cell proliferation and cell loss. Apoptosis is important not only in physiological conditions but in pathological processes as well. Apoptosis has been implicated in the pathogenesis of certain renal diseases. In human models, systemic lupus erythematosus (SLE) and IgA nephropathy have been the main interests. These studies have mainly shown that apoptosis is important in the control of mesangial cell population. We have attempted to define the role of apoptosis in a cohort of childhood lupus nephritis. We have analyzed apoptosis by the terminal deoxynucleotidyl transferase (Tdt)-mediated dUTP-biotin nick end-labeling (TUNEL) method in eight SLE pediatric patients, two of whom had hereditary deficiencies of complement components. Although the sample size was small because of the rarity of hereditary complement deficiencies, we have shown that apoptotic activity was the greatest among these pediatric patients. It has been previously suggested that in lupus, autoimmunity develops as a result of inadequate clearance of apoptotic blebs containing nuclear elements; complement deficiencies are the most important hereditary factors predisposing to the inadequate clearance of apoptotic particles. This is the first time this hypothesis has been evaluated in the tissue samples of hereditary complement deficiency-related proliferative lupus nephritis. On the other hand, apoptosis was not different from the other mesangial proliferative glomerulopathies in the lupus nephritis samples. Further studies are needed to confirm our preliminary findings. Apoptosis has been implicated in other renal diseases as well, such as autosomal polycystic kidney disease, and in experimental models. A short review of the relevant literature is presented highlighting the role of apoptosis in the pathogenesis and prognosis of certain renal diseases.

Apoptosis↗
PubMedDate not supplied

Membranoproliferative glomerulonephritis in sibs.

Idiopathic membranoproliferative glomerulonephritis (MPGN) is a chronic renal disease with variable clinical expression and several distinct morphological subtypes. Two sibs, aged 10 and 13, presented with clinical and laboratory findings of MPGN at the time of admission. After an interval of one year, the diagnosis of MPGN was established by renal biopsies. The complement pathway was unremarkable. HLA typing in the unrelated parents and the two male sibs revealed common HLA A2,A11,Bw60, DR2,DQw1 antigens in the brothers. Of these antigens, A2 has been reported previously in cases of MPGN. The other antigens regarding this disease need to be evaluated from the standpoint of genetic importance.

Adolescent↗
PubMedDate not supplied

Immunofluorescence study of childhood renal amyloidosis.

In this paper, the findings of immunofluorescence (IF) studies of 57 patients with childhood biopsy-proven renal amyloidosis are presented. All specimens were investigated by the direct IF technique and the simultaneous use of antisera to human IgG, IgM, IgA, fibrinogen and C3. Antisera to C1q, C4, HbsAg, IgE (in each of ten cases), kappa and lambda light chains of immunoglobulins (Igs) and albumin (in each of five cases) were also used. AA type amyloidosis was determined in all patients by Wright's potassium permanganate reaction. In thirty-four of these patients (60%), Familial Mediterranean Fever (FMF) was found to be the underlying disease for renal amyloidosis. In 39 cases (68.5%), renal biopsy showed positive fluorescence staining while in 18 cases (31.5%), fluorescence staining was negative. The immunofluorescence pattern of glomerular deposits was neither granular nor linear but large isolated or confluent masses which were located in the mesangium and in the capillary walls, and were similar in all cases whatever the antisera used. The areas showing immunofluorescence staining almost corresponded to the locations of amyloid deposits. Immunoreactants showed various combinations of deposition with the exception of IgE, HbsAg and albumin antisera which yielded continuously negative reactions. C3 was the immunoreactant most commonly encountered. Kappa and lambda light chains of lgs were demonstrated in one of five biopsy specimens tested. Although it was not diagnostic, this IF pattern was found to be rather characteristic. Demonstration of immunoglobulins and other components of the humoral immune system is not a rare occurrence in renal amyloidosis, and passive absorption of plasma proteins does not simply explain these immunohistologic findings.

Adolescent↗
PubMedDate not supplied

The association of nephrotic syndrome and renal vein thrombosis: a clinicopathological analysis of eight pediatric patients.

Cases with a pathological diagnosis of renal venous thrombosis (RVT) associated with nephrotic syndrome (NS) were studied retrospectively for clinicopathological evaluation. The material consisted of 21 RVT cases which were diagnosed in 2000 consecutive pediatric necropsies, with an overall incidence of about one percent. Eight of the 21 RVT cases were associated with nephrotic syndrome (34%), and this group formed 0.4 percent of the total necropsies in our pediatric center. The glomerulopathies of these nephrotic patients consisted of three cases of Finnish-type congenital NS (FCNS), three cases of renal amyloidosis secondary to familial Mediterranean fever, and two cases of membranoproliferative glomerulonephritis (MPGN). The presence of sepsis associated with disseminated intravascular coagulation, and the morphological age of the thrombi suggested that the RVT was secondary to sepsis in the FCNS cases. In the MPGN and secondary renal amyloidosis cases, the long duration of both the nephrotic state and the administration of diuretics along with glucocorticoid treatment and also the newly formed thrombi without infarction are strong evidences, although not definite, that the RVT developed as a complication of the glomerulopathy. Even though there were no definite clinical criteria for the diagnosis of most of the RVT cases, we would like to emphasize the importance of flank pain, the rapid deterioration of renal functions in a stable nephrotic patient, as well as the hypercoagulable state in the consideration of the development of RVT which indicate the need for appropriate radiological studies for confirmation of this condition during life.

Adolescent↗
PubMedDate not supplied

Urinary tract tuberculosis in a child with Henoch-Schönlein purpura: a case report.

A seven-year-old girl is presented, who was previously diagnosed as having Henoch-Schönlein vasculitis, and was further evaluated for hypertension. Urograms showed bilateral strictures of the ureter, causing obstruction on the left side. Tuberculosis, our preoperative diagnosis, evidenced by her sterile pyuria and PPD conversion was confirmed by the surgical specimen and treatment was begun.

Child↗
PubMedDate not supplied

Aortic thrombosis in the newborn infant.

Two cases are reported in which thrombus was found in the aorta at postmortem. In one case the thrombus had originated within the ductus arteriosus. In the other case, the thrombus was associated with congenital heart disease and polycythaemia.

Aortic Diseases↗