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Biomedical subjects

K Tinaztepe

Publications and source records attributed to K Tinaztepe.

At least 19 recordsLinked to original sources
PubMed1990

Acute hemorrhagic edema of infancy (AHEI)--a variant of Henoch-Schönlein purpura or a distinct clinical entity?

Acute hemorrhagic edema of infancy (AHEI) is an acute cutaneous leukocytoclastic vasculitis (LCV) of infants. The clinical picture has a violent onset with a short benign course followed by spontaneous complete recovery. We report 12 infants with AHEI who were studied clinically, serologically, and immunohistologically. Edema and palpable purpuric skin lesions were present in all infants who were in good general condition. Serologic studies were unremarkable. Light microscopic examination of the skin biopsy specimens revealed LCV as in Henoch-Schönlein purpura (HSP). Direct immunofluorescent study revealed depositions of various immunoreactants, including fibrinogen, C3, IgG, IgM, IgA, and IgE (100%, 100%, 22%, 78%, 33%, and 33%, respectively) in the wall and around the small vessels. Similar deposition of Clq was also present in three infants in whom Clq could be studied (100%). The clinical similarities and differences between AHEI and HSP have been discussed in the literature. AHEI is observed before 2 years of age and is confined to the skin. The skin lesions of HSP are more polymorphic. Although histopathologic findings are similar, the immunohistologic pattern found in our series of AHEI is rather different from the pattern of HSP. Taking all of these findings into account, we suggest that AHEI should be considered as a separate, clinicopathologic entity or a possible variant of HSP. The more descriptive term "acute benign cutaneous LCV of infancy" is offered for this clinicopathologic entity.

Acute Disease↗
PubMed1979

[Immunologic aspects of the nephrotic syndrome].

Evidence that immunological mechanisms playing a major role in certain forms of nephrotic syndrome are obtained from immunopathologic observations, by analogy to certain form of experimental renal disease and by alterations in serum complement and complement component levels. This group of disease includes a variety of glomerulonephritis in which antigen-antibody-complexes and anti-glomerular basal membrane antibodies play a role in their pathogenesis. There are also evidences that the alternate complement pathway may be involved in certain forms of immune related glomerulonephritis. The precise etiology of idiopathic nephrotic syndrome having unique characteristics separating it from nephrotic syndrome associated with glomerulonephritis, is yet unknown. However, there are some circumstantial evidences depending on clinical observations that it may be an immunological disorder. It is possibly produced by a systemic abnormality of T-cell function resulting in the secretion of a circulating chemical mediator, toxic to the glomerular basement membrane; but there is not yet direct proof to substantiate this hypothesis.

Antibodies↗
PubMedDate not supplied

Metastatic Wilms' tumor in the right atrium propagated through the inferior vena cava.

A patient with a rare case of cardiac tumor in the right atrium secondary to Wilms' tumor of the right kidney, underwent open heart surgery and removal of the mass was presented. This is the 10th. case of intracardiac tumor secondary to renal malignancy. Careful auscultation of the heart is necessary in patients with malignancy in the kidney to detect the possible right heart metastases through the inferior vena cava. Cardiac symptoms precede the renal manifestations in most cases. Malignant renal metastases to the heart should always be in mind in space occupying masses of the right heart chambers.

Cardiac Catheterization↗