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Biomedical subjects

K Tillmann

Publications and source records attributed to K Tillmann.

78 records · Page 5Linked to original sources

Resection interposition arthroplasty of the shoulder affected by inflammatory arthritis.

To determine the therapeutic value of resection-interposition arthroplasty (RIAP) of shoulders in rheumatoid or other inflammatory arthritis, 53 patients were reviewed clinically and radiographically after a mean follow-up period of 8.2 +/- 4.3 years (3.5 to 17.5 years). The Constant Score averaged 42.33 +/- 16.2 (12 to 76). Patients with a follow-up period of more than 10 years performed significantly worse than those with shorter follow-up periods. In most cases, radiographs showed a progressive medial displacement and loss of size of the humeral head as well as a decrease of the joint space with time. Abduction proved to be highly dependent on the degree of medial displacement of the humeral head, whereas the Constant Scores correlated with the width of the joint space. Despite initially acceptable postoperative results, outcome at longer follow-up periods worsened as the result of wear of the glenoidal cartilage and osseous resorption of the humeral head, resulting in a progressive medialization of the center of rotation.

Aged↗

[Indications for emergency operations in rheumatoid orthopedics].

In arthritis surgery "urgent" indications are a relatively subjective definition--apart from few exceptions. The aim of this paper is to give a substantiated classification--under practical aspects--for frequently occurring rheumatoid lesions in all parts of the locomotor system requiring surgical treatment.

Arthritis, Rheumatoid↗

Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue.

Elastase, an enzyme in the azurophilic granules of polymorphonuclear cells (PMN), is like other granular PMN proteases characterized by its degradative activity at physiological pH towards native macromolecules as shown in a serum free medium. Joint tissue specimen obtained during elective surgery in cases of various rheumatic conditions were examined in order to elucidate the role of this enzyme during joint cartilage destruction. An indirect immunofluorescence microscopic technique utilizing a rabbit immunoglobulin G preparation raised against purified elastase was used for this purpose. Immunoreactive elastase was seen bound to cells which were recognized as PMN by their nuclear characteristics and staining in a histochemical reaction with naphtol AS-D chloroacetate. PMN were encountered more or less often in the pannus but clearly accumulated in a significant amount at the pannus-cartilage junction in one case of rheumatic monarthritis and three out of four cases with rheumatoid arthritis. This finding shows that PMN--contrary to other descriptions--belong to the morphologic characteristics of inflammatory rheumatic conditions and directly supports the hypothesis that PMN enzymes play an active role in rheumatoid cartilage destruction.

Arthritis, Rheumatoid↗