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Biomedical subjects

K Thielmann

Publications and source records attributed to K Thielmann.

At least 37 records · Page 2Linked to original sources
PubMed1980

Anticoagulant-free prepared blood platelets and the effect of calcium on their aggregation behaviour.

Human blood platelets were prepared by gel filtration of native blood and subsequent centrifugation in a Ficoll density gradient avoiding any anticoagulant during the preparation. In ADP, ionophore A 23 187 and thrombin induced aggregation an increase in extracellular Ca++ enhanced the velocity of aggregation. From a defined Ca++ concentration threshold on there was a shift from monophasic to biphasic aggregation.

Adenosine Diphosphate↗
PubMed1980

Intraindividual variability of plasma cholesterol and triglycerides and the effect of propranolol treatment.

In 114 male subjects cholesterol and triglyceride concentrations in plasma after overnight fasting were followed up during 12 weeks. About one third of the individuals showed pronounced day to day variations of their cholesterol or/and triglyceride levels. Considerable intraindividual variability was moreover found for HDL cholesterol. Plasma lipid instability was more frequent in hyperlipemics and in subjects with low HDL cholesterol than in normolipemics. It was tried to level out the fluctuations by a beta blocking agent. Propranolol was used and proved to reduce the fluctuations of total cholesterol. However, at the same time the concentrations of triglycerides were increased and those of HDL cholesterol decreased. Practical consequences of both the fluctuating plasma lipid concentrations and the propranolol effects are stressed.

Adult↗
PubMed1980

The effect of propranolol treatment on total cholesterol, HDL cholesterol, triglycerides. Postheparin lipolytic activity and lecithin:cholesterol acyltransferase in hypertensive individuals.

Administration of 120 mg propranolol per day to hypertensive patients is followed by decreased plasma concentrations of total cholesterol and HDL cholesterol and increased concentrations of triglycerides. Postheparin lipolytic activity was reduced when measured 5 min after heparin administration. The activity of lecithin:cholesterol acyltransferase is diminished. Reduced activity of this enzyme by propranolol could be demonstrated in vitro as well.

Adolescent↗
PubMed1979

[Suitability and recovery of capillary blood plasma for lipid determinations].

Plasma lipid analysis, particularly in population screening, can be facilitated by the use of capillary blood. A system for serial collection of capillary plasma is described. The concentrations of total cholesterol, HDL-cholesterol and triglycerides in heparinized capillary plasma and venous blood, respectively, are compared. No significant differences were found. Using the KAPA-method hemolytic samples are a source of error. They occurred with a frequency of about 3% in mass screening.

Capillaries↗
PubMed1977

[Cardiovascular preventive medical check-ups in the large industrial plants of Erfurt. 1. Implementation of the screening phase].

During a medical check-up for the recognition and treatment of patients with diseases of heart and circulation or their early stages and of patients with factors of risk in two large factories of Erfurt altogether 6,646 men and women were examined. The screening was carried out in November 1975 and 1976 in immediate nearness of the working place. The times during which could not be worked were thus reduced to a minimum. Some organisational problems and their solutions in the preparation and performance of the screening phase as well as first results are reported on.

Cardiovascular Diseases↗
PubMed1977

Principle and application of a multicuvette for determination of enzyme activities and substrate concentrations in microsamples.

A method of photometric analysis is described that allows to determine enzyme activities or substrate concentrations of 50 samples simultaneously in a multicuvette. Test volume is in the range of 30-85 micronl, light path between 0.5 and 2.0 mm. The testing principle can be used for colorimetric measurements and for NADH dependent reactions as well. The procedure is particularly suited for kinetic determinations. Variation coefficients for determinations of substrate concentrations and enzyme activities are in the range of conventional enzymatic tests.

Kinetics↗
PubMed1977

[Some remarks on recent trends in pathology (author's transl)].

The present situation of pathology is analysed. Concerning the German Democratic Republic the situation is characterized by a consequent separation of the pathology into the special branches of pathomorphology, pathophysiology, and pathobiochemistry.

Germany, East↗