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Biomedical subjects

K Thestrup-Pedersen

Publications and source records attributed to K Thestrup-Pedersen.

At least 163 records · Page 9Linked to original sources
PubMed1987

Sweat pore density on the fingertips of atopic patients.

Investigation of 18 patients with atopic eczema and 22 normal controls showed that women in both groups had significantly more sweat pore openings on their fingertips than men and that there were more glands per unit area on fingers 3 and 4 compared with the thumb and the first and second fingers. There was no significant difference in the number of sweat pores between normal and atopic individuals, although fingertip topography in the latter was disturbed.

Adolescent↗
PubMed1987

Patch test reactivity to nickel alloys.

11 widely used nickel alloys were investigated with respect to corrosion stability and reactivity in nickel-sensitive individuals. Alloys with a nickel release in synthetic sweat exceeding 1 microgram/cm2/week gave a strong patch test reaction in nickel-sensitive persons; those with a release below 0.5 microgram/cm2/week showed weak reactivity with one exception. Nickel allergy is a health problem. It may be minimized by using nickel alloys with a corrosion level below 0.5 microgram/cm2/week. Action should be taken by dermatologists, industry and authorities to solve this neglected problem.

Alloys↗
PubMed1987

Ciclosporin A in acrodermatitis continua.

A case is presented of a 58-year-old female exhibiting a severe pustular psoriasis of the acrodermatitis continua type treated with ciclosporin A. The disease which had lasted for 10 years and had lead to 14 hospitalizations had previously been treated with methotrexate, systemic steroids, etretinate, colchicine, hydroxyurea and PUVA, or combinations of some of these drugs without producing complete remissions. Ciclosporin A (14 mg/kg/day/reduced to 7.5 mg/kg/day) produced complete remission in three weeks. Whether the patient can be maintained on low-dose ciclosporin A without toxicity remains to be seen. The drug, however, seems to be effective in bringing the disease under control.

Acrodermatitis↗
PubMed1987

Combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides: a six-year experience.

A six-year experience in 20 patients with advanced mycosis fungoides treated with combination chemotherapy with bleomycin, cyclophosphamide, prednisone and etretinate (BCPE) in advanced mycosis fungoides showed initial complete remissions in 16 patients (85%). The initial complete remissions lasted in average 8 months. A second complete remission was obtained in seven patients. The overall survival after 2 years was 50% and 30% after 4 years. At the time of the investigation six patients are alive, three in complete remission and three in partial remission. Two patients are in partial remission after 6 years, one of these had additional therapy with alfa-interferon. Patients entering the study until 1982 also received transfer factor, an immune stimulating agent. Since in 1982 a double-blind study revealed no differences between patients given the active--and patients given the inactive medication, no new patients since then had transfer factor. BCPE compares favourable with other chemotherapeutic regimes. The data presented seem to justify the use of retinoids as a part of combination chemotherapy in mycosis fungoides.

Adult↗
PubMed1987

Adverse reactions in the skin from anti-hypertensive drugs.

Anti-hypertensive drugs, including diuretics and beta-blocking drugs, belong to a group of therapeutics used by about a fourth of the Danish population. As with cytostatics, antibiotics, and topical remedies, they rather frequently cause adverse drug reactions (ADR) in the skin. No exact statistical information is available concerning the extent of such side effects. The information obtained by Danish National Board of Health's Committee on Adverse Drug Reactions shows that 10-60% of ADR from diuretics, beta-blocking agents, and anti-hypertensive drugs are dermatological. The skin symptoms are not unique for any specific drug. But certain symptoms occur more frequently than others. Thiazides can give vasculitis, a phototoxic/-allergic eruption, erythema multiforme, or eczema. The combination of amiloride (5 mg) and hydrochlorothiazide (50 mg) carries the highest number of recorded ADR; 59% of these are in the skin. Half of the skin ADR are phototoxic eczema. Furosemide may give eczema, purpura, a bullous eruption, or Steven-Johnson's syndrome in rare cases. Methyldopa can induce eczematous eruptions on hands and feet, a lichenoid eruption, a lupus erythematosus-like eruption, or purpura. Hydralazine may give lupus erythematosus-like eruptions, eczema, or urticaria. Non-specific beta-blocking drugs can induce a morbilliform rash and may aggravate psoriasis. Captopril may induce pruritus in up to 15% of the patients and skin eruptions in 2%. The most serious dermatological side effect, exfoliative dermatitis, is very rarely seen following the use of anti-hypertensive drugs or diuretics.

Adrenergic beta-Antagonists↗
PubMed1986

Natural and concanavalin A-induced cytotoxic activity towards continuously growing B lymphocytes derived from patients with cutaneous T-cell lymphoma.

Continuously growing T- and B-cell lines were derived from peripheral blood, affected skin, and lymph nodes of patients with mycosis fungoides (MF) and Sézary syndrome (SS). Two lymphoblastoid cell lines (MF-13 and SS-2) were Epstein-Barr virus (EBV)-transformed B cells evaluated by surface immunoglobulin, lack of E-rosette formation, positive EBV nuclear antibody test, and secretion of IgM antibody in a plaque-forming cell assay. Analysis of the natural-killer-cell activity using peripheral blood lymphocytes from patients with MF and healthy control persons towards MF-13 and SS-2 target cells suggested resistance to lysis even in tests supplemented with 1,000 IU/ml human gamma-interferon. However, the cell lines were not per se completely resistant to lysis because lymphocytes from control persons showed significant cytotoxicity in an 18-h assay supplemented with 2 micrograms/ml concanavalin A.

Adult↗
PubMed1986

Epidermis and lymphocyte interactions during a tuberculin skin reaction. II. Epidermis contains specific lymphocyte chemotactic factors.

Lymphocyte chemotaxis was studied in a blind-well chamber assay by measuring the passage of 51Cr-labeled cells through a polycarbonate filter with a pore size of 5 micron. Monocyte-depleted lymphocytes were divided into T cells (E receptor-positive lymphocytes) and non-T cells. T lymphocytes showed pronounced migration after exposure to leukotriene B4 (LTB4) and casein, and weak migration after exposure to N-formyl-methionyl-leucyl-phenylalanine (FMLP). Non-T cells showed strong migration after exposure to FMLP, but weak migration after exposure to casein and LTB4. Supernatants of homogenized suction blisters from normal skin did not induce active migration. However, if the epidermis came from an area overlying a positive tuberculin skin reaction, there was a significant migration mostly of T, but also of non-T cells. Supernatants from phytohemagglutinin (PHA)-stimulated lymphocyte cultures also contained lymphocyte chemotactic factor(s), which, however, had an effect only on T lymphocytes. Purified protein derivative of tuberculin (PPD)-stimulated lymphocytes did not produce chemoattractants either for T or for non-T cells. These studies show that lymphocytes can show active, directed migration following exposure to well-known chemotaxins for granulocytes and monocytes although their migrational capability differs for different subpopulations. Epidermis overlying a cell-mediated immune reaction (tuberculin) contains epidermal lymphocyte chemotactic factor(s). This factor(s) may be of importance for the type of cell infiltrate occurring in certain dermatologic disorders.

Caseins↗
PubMed1985

Serum angiotensin-converting enzyme in sarcoidosis and psoriasis.

Untreated pulmonary sarcoidosis is associated with an increased level of serum angiotensin-converting enzyme (SACE), which is regarded as a valuable method of diagnosing sarcoidosis and measuring the activity of the disease. The level of SACE in cutaneous sarcoidosis or other skin diseases has not been clearly established. We therefore examined SACE in 31 patients with systemic sarcoidosis, including cutaneous manifestations, and 12 patients with isolated cutaneous sarcoidosis. Also, 23 patients with psoriasis were studied. The level of SACE was generally elevated only in patients with untreated systemic sarcoidosis, whereas it was normal in cutaneous sarcoidosis and psoriasis. If the level of SACE is elevated in "isolated" cutaneous sarcoidosis, systemic disease must be strongly suspected.

Female↗
PubMed1985

Lymphocyte subsets in patients with compositae oleoresin dermatitis and increased UVA sensitivity during treatment with azathioprine.

Four patients with severe contact dermatitis resulting from compositae oleoresin were found to have increased sensitivity to ultraviolet light. All showed a clear reduction of Leu-3a-positive lymphocytes (T helper/inducer cells) and cells expressing the Ia phenotype in their blood. The numbers of T suppressor/cytotoxic (Leu 2a) lymphocytes, monocytes and B lymphocytes were within the normal range. Treatment with azathioprine (150 mg daily) improved the eczema. The number of Leu-3a-positive lymphocytes normalized during therapy, but the number of Ia-positive cells did not.

Aged↗
PubMed1985

Neutrophil and monocyte chemotaxis in pustulosis palmo-plantaris and pustular psoriasis.

Polymorphonuclear leukocyte (PMN) and monocyte (MN) chemotaxis in nine patients with pustulosis palmo-plantaris (PPP) and ten patients with pustular psoriasis (PP) was determined by an objective in vitro assay employing a 51Cr-labelling technique. PMN chemotaxis was significantly enhanced in both groups of patients compared with controls. MN chemotaxis was normal. There was no difference in the chemotactic responsiveness of leukocytes from patients with PPP and PP. The random migration of PMN and MN from the patients was normal. Homogenized tissue specimens from lesional skin with and without pustules, and from perilesional, normal-looking skin of PPP and PP were analysed for the presence of chemoattractant(s) for PMN. Lesional skin had considerable chemoattractant properties, but perilesional skin did not induce directed migration of PMNs.

Adult↗
PubMed1985

Topical nitrogen mustard in early mycosis fungoides. A 12-year experience.

A 12-year experience in thirty-three patients suffering from early mycosis fungoides in plaque stage confirms the effectiveness of topical nitrogen mustard therapy. Fourteen patients were in complete remission at the latest time of observation and 7 in partial remission. The probability of freedom from relapse was approximately 50% after 6 and 12 years. Three deaths attributable to mycosis fungoides were recorded. Three patients had to discontinue treatment due to contact dermatitis to nitrogen mustard. Specific precautions were undertaken in order to protect personnel handling the drug. No damaging or toxic effects were observed among staff personnel and no hematological side-effects were observed among the patients. The treatment as a whole was well tolerated.

Administration, Topical↗
PubMed1985

The Klippel-Trenaunay syndrome with acro-angiodermatitis (pseudo-Kaposi's sarcoma).

A patient with the Klippel-Trenaunay syndrome and pseudo-Kaposi elements is reported. This combination of symptoms has only been published very occasionally. Selective quantitative measurements of the peripheral tissue blood flow revealed a significantly increased cutaneous blood flow in the hypertrophied leg. This finding supports the assumption that a high perfusion rate and a high oxygen saturation are involved in the etiopathogenesis of the pseudo-Kaposi elements.

Acrodermatitis↗